Integrated Physiology Training: Molecule to Organism

综合生理学培训：分子到有机体

• 批准号: 10553817
• 负责人: Matthew Robert Hodges
• 金额: $ 43.39万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553817
• 关键词: Organism; Physiology; Training

Project Summary Scientific training in the Physiological sciences in the U.S. has undergone a transformation largely toward molecular mechanisms and away from whole animal integrative physiology, creating a shortage of scientists and educators with mastery of integrative physiology. The Physiology training program at the Medical College of Wisconsin (MCW) is an exception to this trend. Our training program offers multidisciplinary instruction and cutting-edge integrative physiology research training emphasizing the integration of knowledge from the molecule to cell to organ to organism. Trainees develop the critical thinking, integrative reasoning, and technical skills participating in research focused on the prevention and control of HLBS diseases such as hypertension, metabolic disease, epilepsy and chronic respiratory diseases. Our current proposal maintains a focus on critical thinking, organ systems physiology and translational research training with enhancements in: 1) interdisciplinary instruction, 2) self-directed learning, 3) the trainee candidate pool, 4) the acceleration of reaching training milestones, 5) instruction in rigor and reproducibility in the scientific method, and 6) the recruitment of students from populations underrepresented in science and medicine. Trainees are recruited nationally from geographically diverse areas and selected on a competitive basis on undergraduate academic credentials, previous research experience, and commitment to a career in research in the Physiological Sciences. Students are full-time PhD candidates, and must successfully complete the course and research requirements, including passing the Qualifying Exam before being considered for NIH training grant support. Selection of T32 trainees will be based on several performance metrics in coursework and research productivity, in addition to the alignment of their research focus in the Physiological sciences and the candidate’s potential for a successful career in the biomedical sciences. An innovative feature of the training program is to meet the anticipated need to train students in integrative physiology to meet the growing need for such expertise in the era of Team Science and in the post-genomic era. Research training is under the direct supervision of highly skilled and experiences faculty preceptors in the basic sciences (primarily Physiology) and enhanced by clinical faculty. Trainees will undergo continuous evaluation of progress by Individual Development Plans that facilitate career development and progress toward individualized trainee goals. The success of our program in training is evidenced by a high completion rate and publication record of the twelve T32 supported graduates in the past 10 years, who had 25 first-authored and 42 co-authored publications (~5.6/trainee). The high number of co-authored publications reflects the highly collaborative environment among our faculty and Team Science approach. Each of these trainees has gone on to academic research, teaching or patient care positions indicative of the success of our approach to ensuring the future of integrative physiology into the future. Based on the long-term success of our training program, we hereby request funds to support 8 predoctoral students in each of the next 5 years.

项目摘要 美国生理科学的科学培训经历了一个转变，主要是朝着 分子机制，远离整个动物的综合生理学，造成科学家和 具有综合生理学知识的教育家。在医学院的生理学培训计划， 威斯康星州（MCW）是这种趋势的一个例外。我们的培训计划提供多学科教学， 尖端的综合生理学研究培训，强调知识的整合，从 从分子到细胞到器官再到有机体。学员发展批判性思维，综合推理和技术 技能参与研究重点是预防和控制HLBS疾病，如高血压， 代谢疾病、癫痫和慢性呼吸道疾病。我们目前的建议将重点放在关键的 思维，器官系统生理学和转化研究培训，增强：1）跨学科 指导，2）自我导向学习，3）学员候选人库，4）达到培训的加速 里程碑，5）科学方法的严谨性和可重复性的指导，以及6）学生的招募 在科学和医学领域代表性不足的人群。受训人员从全国各地征聘， 地理上不同的地区，并在竞争的基础上选择本科学历， 以前的研究经验，并致力于在生理科学研究的职业生涯。学生 是全日制博士候选人，必须成功完成课程和研究要求，包括 在被考虑获得NIH培训补助金支持之前通过资格考试。选择T32受训人员 将基于课程和研究生产力的几个性能指标，除了 他们在生理科学的研究重点和候选人的成功潜力的对齐 在生物医学科学的职业生涯。培训计划的一个创新特点是满足预期的需求 培养学生综合生理学，以满足团队科学时代对此类专业知识日益增长的需求 以及后基因组时代。研究培训是在高技能和经验的直接监督下进行的。 基础科学（主要是生理学）的教师导师，并由临床教师加强。学员将 通过促进职业发展的个人发展计划不断评估进展情况 并朝着个性化的学员目标前进。我们的培训计划的成功是由一个高证明 过去十年，十二名获T32资助的毕业生的毕业率及发表论文纪录， 第一作者和42篇合著出版物（约5.6篇/学员）。大量共同撰写的出版物 反映了我们的教师和团队科学方法之间的高度协作环境。这一切成功都 受训人员已进入学术研究，教学或病人护理职位，这表明我们的成功 方法，以确保未来的综合生理学的未来。基于我们的长期成功， 培训计划，我们特此申请资金，以支持8个博士生在未来5年每年。

项目成果

Pulmonary arterial dilation by inhaled NO: arterial diameter, NO concentration relationship.

吸入NO引起的肺动脉扩张：动脉直径、NO浓度关系。

• DOI: 10.1152/jappl.2001.91.5.1948
• 发表时间: 2001
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Bentley,J;Rickaby,D;Haworth,ST;Hanger,CC;Dawson,CA
• 通讯作者: Dawson,CA

RNASeq-derived transcriptome comparisons reveal neuromodulatory deficiency in the CO2 insensitive brown Norway rat.

RNASeq 衍生的转录组比较揭示了对 CO2 不敏感的棕色挪威大鼠的神经调节缺陷。

• DOI: 10.1113/jphysiol.2014.285171
• 发表时间: 2014
• 期刊: The Journal of physiology
• 作者: Puissant,MadeleineM;Echert,AshleyE;Yang,Chun;MouradianJr,GaryC;Novotny,Tyler;Liu,Pengyuan;Liang,Mingyu;Hodges,MatthewR
• 通讯作者: Hodges,MatthewR

Novel adaptive and innate immunity targets in hypertension.

• DOI: 10.1016/j.phrs.2017.03.015
• 发表时间: 2017-06
• 期刊: Pharmacological research
• 影响因子: 9.3
• 作者: Abais-Battad JM;Dasinger JH;Fehrenbach DJ;Mattson DL
• 通讯作者: Mattson DL

Global identification and characterization of tRNA-derived RNA fragment landscapes across human cancers.

人类癌症中 tRNA 衍生的 RNA 片段景观的全球鉴定和表征

• DOI: 10.1093/narcan/zcaa031
• 发表时间: 2020-12
• 期刊: NAR cancer
• 影响因子: 5.1
• 作者: Sun X;Yang J;Yu M;Yao D;Zhou L;Li X;Qiu Q;Lin W;Lu B;Chen E;Wang P;Chen W;Tao S;Xu H;Williams A;Liu Y;Pan X;Cowley AW Jr;Lu W;Liang M;Liu P;Lu Y
• 通讯作者: Lu Y

Tnni3k influences cardiomyocyte S-phase activity and proliferation.

• DOI: 10.1016/j.yjmcc.2023.08.004
• 发表时间: 2023-08
• 期刊: Journal of molecular and cellular cardiology
• 影响因子: 5
• 作者: Alexandra L Purdy;Samantha K Swift;H. Sucov;Michaela Patterson