Expanding Excellence in Developmental Biology in Oklahoma

扩大俄克拉荷马州发育生物学的卓越水平

• 批准号: 10225569
• 负责人: Linda F Thompson
• 金额: $ 256.36万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10225569
• 关键词: Address; Advisory Committees; Age; Aging; Animal Model; Appointment; Area; Award; Biological Models; Biomedical Research; Caenorhabditis elegans; Cardiovascular system; Cell Culture Techniques; Cells; Centers of Research Excellence; Chronic Obstructive Airway Disease; Communities; Conflict (Psychology); Core Facility; Development; Developmental Biology; Developmental Process; Disease; Dropout; Drosophila genus; Environment; Epigenetic Process; Experimental Models; Faculty; Fertilization; Funding; Genome; Goals; Growth; Health; Hematopoietic stem cells; Human; Hyperplasia; Immune system; Infrastructure; Infusion procedures; Institution; Interdisciplinary Study; International; Intestines; Journals; Longevity; Mentors; Mitochondria; Molecular; Mucous body substance; Mus; Natural regeneration; Neurodegenerative Disorders; Oklahoma; Paper; Phase; Physiological Processes; Planarians; Positioning Attribute; Publications; Publishing; Regenerative Medicine; Research; Research Personnel; Research Support; Resources; Scientist; Senior Scientist; System; Systems Development; Talents; Technology; The Sun; Time; Training; Transcriptional Regulation; Translating; United States National Institutes of Health; Universities; Work; Zebrafish; biological adaptation to stress; career; competitive environment; genetic deafness; healing; human disease; induced pluripotent stem cell; meetings; member; mouse model; novel therapeutic intervention; operation; programs; recruit; success; tool; trend

ABSTRACT Our overall goal is to strengthen our Developmental Biology COBRE by mentoring five newly-recruited investigators, each studying important questions in Developmental Biology with translational implications. We will build upon our success in Phase I when our COBRE Investigators made important discoveries resulting in 53 published papers (many in high-impact journals), 91 presentations at invited seminars or scientific meetings, and the awarding of more than $9.75 million in external funding, including 3 R01s and a R56. We will also continue to build our infrastructure by strengthening and expanding our scientific Cores. Developmental Biology is fundamental to progress in determining the molecular basis of many diseases, as well as for the rapidly emerging field of regenerative medicine. Our new Junior Investigators will use a variety of experimental model systems to explore fundamental developmental processes that are compromised by disease, or might be manipulated to promote healing. Their research areas include intestinal regeneration (planarians), stress responses and aging (C. elegans), mucous cell hyperplasia leading to chronic obstructive pulmonary disease (human cell culture and mouse models), genetics of deafness (zebrafish), and neurodegenerative diseases (Drosophila). The addition of five new Junior Investigators will help create the critical mass necessary for a sustainable community where Developmental Biologists can flourish. Phase II COBRE support will allow us to implement an ideal program for launching the careers of these new investigators by providing committed mentoring from internal and external scientists, building and maintaining outstanding Core facilities for advancing Developmental Biology research, and integrating the new investigators into the growing Developmental Biology community in Oklahoma. This will be accomplished through the following Specific Aims: Aim 1. To grow our multi-disciplinary research program in Developmental Biology through the nurturing of a talented group of Junior Investigators with outstanding potential to become leaders in their fields Aim 2. To mentor the Junior Investigators, using a combination of senior scientists and recently graduated COBRE Junior Investigators within existing OMRF and University of Oklahoma faculty Aim 3. To form an External Advisory Committee of internationally recognized Developmental Biologists to evaluate the progress of, and offer advice to, the Junior Investigators Aim 4. To maintain and expand Core facilities that will support the research of the Junior Investigators and lay the groundwork for their sustainable operation after COBRE funding ends. Aim 5. To promote scientific interactions among the Junior Investigators and create an environment conducive to investigator retention.

摘要 我们的总体目标是通过指导五名新招聘的人员来加强我们的发育生物学核心 研究人员，每个人都在研究发育生物学中的重要问题，并具有翻译意义。我们 我们将在第一阶段取得成功的基础上再接再厉，当时我们的Cobre调查人员做出了重要发现，导致 53篇发表论文(许多发表在影响较大的期刊上)，91篇在受邀研讨会或科学研讨会上发表的演讲 会议，以及提供超过975万美元的外部资金，其中包括3架R01和1架R56。我们会 也继续通过加强和扩大我们的科学核心来建设我们的基础设施。发展中 生物学是在确定许多疾病的分子基础方面取得进展的基础，对于 迅速崛起的再生医学领域。我们的新初级调查员将使用各种实验性的 探索受疾病或疾病危害的基本发育过程的模型系统 被操纵以促进治愈。他们的研究领域包括肠道再生(脊椎动物)、应激 反应和衰老(线虫)，粘液细胞增生导致慢性阻塞性肺疾病 (人类细胞培养和小鼠模型)、耳聋遗传学(斑马鱼)和神经退行性疾病 (果蝇)。增加五名新的初级调查员将有助于创造必要的临界量 发展生物学家可以蓬勃发展的可持续社区。第二阶段Cobre支持将使我们能够 实施一个理想的计划，通过提供承诺来启动这些新调查人员的职业生涯 来自内部和外部科学家的指导，建设和维护卓越的核心设施 推进发育生物学研究，让新的研究人员融入成长中 俄克拉荷马州的发育生物学社区。这将通过以下具体的 目标： 目标1.通过培养一名学生，发展我们的发育生物学多学科研究项目 一群才华横溢的初级调查人员，具有成为各自领域领导者的突出潜力 目标2.指导初级调查人员，使用资深科学家和新近毕业的人员 现有OMRF和俄克拉荷马大学教职员工中的Cobre初级调查人员 目标3.成立由国际公认的发育生物学家组成的外部咨询委员会，以 评估初级调查人员的进展情况，并向他们提供建议 目标4.维持和扩大核心设施，以支持初级调查人员的研究 在科布雷资金结束后，他们为可持续运营奠定了基础。 目标5.促进初级调查员之间的科学互动并创造有利的环境 为了留住调查员。