Expanding Excellence in Developmental Biology in Oklahoma

摘要 我们的总体目标是通过指导五名新招募的 研究人员，每个人都在研究发育生物学中具有翻译意义的重要问题。我们 我们将在第一阶段的成功基础上再接再厉，当时我们的COBRE调查员取得了重要发现， 发表论文53篇（其中许多发表在高影响力期刊上），在受邀研讨会或科学研讨会上作了91次演讲 会议，并授予超过975万美元的外部资金，包括3个R01和R56。我们将 我们还将继续通过加强和扩大我们的科学核心来建设我们的基础设施。发育 生物学对于确定许多疾病的分子基础以及确定疾病的分子基础是至关重要的。 再生医学领域的快速发展。我们新的初级调查员将使用各种实验性的 模型系统，以探索受疾病影响的基本发育过程，或者可能 被操纵来促进愈合他们的研究领域包括肠道再生（Planarians），压力 反应和衰老（C. elegans）、粘液细胞增生导致慢性阻塞性肺疾病 （人类细胞培养和小鼠模型）、耳聋遗传学（斑马鱼）和神经退行性疾病 （果蝇）。增加五名新的初级调查员将有助于创造必要的临界质量， 发展生物学家可以蓬勃发展的可持续社区。第二阶段COBRE支持将使我们能够 实施一个理想的计划，通过提供承诺， 内部和外部科学家的指导，建立和维护优秀的核心设施， 推进发育生物学研究，并将新的研究人员融入日益增长的 俄克拉荷马州的发育生物学社区。这将通过以下具体措施实现： 目的： 目标1。通过培养一个有能力的人来发展我们在发育生物学方面的多学科研究计划。 一群才华横溢的初级研究员，具有成为各自领域领导者的杰出潜力 目标2.指导初级研究员，使用资深科学家和最近毕业的 现有OMRF和俄克拉荷马州大学教师中的COBRE初级研究员 目标3：成立由国际公认的发育生物学家组成的外部咨询委员会， 评估初级研究者的进展并向其提供建议 目标4。维护和扩大核心设施，以支持初级研究者的研究， 为COBRE资金结束后的可持续运作奠定基础。 目标5。促进初级研究员之间的科学互动，并创造一个有利于 调查员的保留权

ABSTRACT Our overall goal is to strengthen our Developmental Biology COBRE by mentoring five newly-recruited investigators, each studying important questions in Developmental Biology with translational implications. We will build upon our success in Phase I when our COBRE Investigators made important discoveries resulting in 53 published papers (many in high-impact journals), 91 presentations at invited seminars or scientific meetings, and the awarding of more than $9.75 million in external funding, including 3 R01s and a R56. We will also continue to build our infrastructure by strengthening and expanding our scientific Cores. Developmental Biology is fundamental to progress in determining the molecular basis of many diseases, as well as for the rapidly emerging field of regenerative medicine. Our new Junior Investigators will use a variety of experimental model systems to explore fundamental developmental processes that are compromised by disease, or might be manipulated to promote healing. Their research areas include intestinal regeneration (planarians), stress responses and aging (C. elegans), mucous cell hyperplasia leading to chronic obstructive pulmonary disease (human cell culture and mouse models), genetics of deafness (zebrafish), and neurodegenerative diseases (Drosophila). The addition of five new Junior Investigators will help create the critical mass necessary for a sustainable community where Developmental Biologists can flourish. Phase II COBRE support will allow us to implement an ideal program for launching the careers of these new investigators by providing committed mentoring from internal and external scientists, building and maintaining outstanding Core facilities for advancing Developmental Biology research, and integrating the new investigators into the growing Developmental Biology community in Oklahoma. This will be accomplished through the following Specific Aims: Aim 1. To grow our multi-disciplinary research program in Developmental Biology through the nurturing of a talented group of Junior Investigators with outstanding potential to become leaders in their fields Aim 2. To mentor the Junior Investigators, using a combination of senior scientists and recently graduated COBRE Junior Investigators within existing OMRF and University of Oklahoma faculty Aim 3. To form an External Advisory Committee of internationally recognized Developmental Biologists to evaluate the progress of, and offer advice to, the Junior Investigators Aim 4. To maintain and expand Core facilities that will support the research of the Junior Investigators and lay the groundwork for their sustainable operation after COBRE funding ends. Aim 5. To promote scientific interactions among the Junior Investigators and create an environment conducive to investigator retention.