Expanding Excellence in Developmental Biology in Oklahoma

描述(由申请者提供)：这个Cobre，在俄克拉荷马州扩展发育生物学的卓越，将支持五个非常有才华的，训练有素的，新雇用的初级研究人员，在发育生物学的不同领域工作。林惠英博士从伯纳姆研究所来到我们这里。她将研究果蝇体内活性氧对心脏发育和功能的调节。洛林·奥尔森博士在山上完成博士后研究后来到OMRF。西奈半岛。他将使用基因工程小鼠作为模型系统，研究PDGF受体在纤维化中的作用。罗伯托·佩扎博士曾在美国国立卫生研究院受训。他将使用纯化的蛋白质、细胞系和小鼠模型来研究减数分裂同源重组过程中DNA链入侵的分子机制。克里斯·桑萨姆博士最近从麻省理工学院来到OMRF。他将利用细胞系和斑马鱼研究有丝分裂过程中DNA修复的机制，无论是在正常发育期间还是在化疗后。王卫东博士来自加利福尼亚州的生物科技公司iPierian。他将开发从诱导的多能干细胞中培养出人类胰岛β细胞的方法，用于治疗1型糖尿病患者。每个初级调查员将被分配两到三名导师，其中一人将担任他们的项目负责人。他们还将得到由Max Cooper博士(主席)、Nicholas Dysan、Eric Olson和Patricia Hunt博士组成的杰出外部咨询委员会的反馈和指导，初级调查人员将得到四个核心的支持：行政核心、生物信息学和路径核心、流式细胞术核心和成像核心。将启动每月一系列研讨会，以促进初级调查人员之间的互动，他们因共同的科学兴趣、实验方法和生物信息学挑战而团结在一起。该中心的建立将促进这些年轻科学家的事业，鼓励发育生物学的多学科研究，并建立基础设施，使OMRF和俄克拉荷马州的整个科学事业受益。

DESCRIPTION (provided by applicant): This COBRE, Expanding Excellence in Developmental Biology in Oklahoma, will support five extremely talented, well-trained, newly-hired Junior Investigators working in diverse areas of Developmental Biology. Dr. Hui-Ying Lim comes to us from the Burnham Institute. She will investigate the regulation of cardiac development and function by reactive oxygen species in Drosophila. Dr. Lorin Olson arrived at OMRF after post-doctoral studies at Mt. Sinai. He will study the role of PDGF receptors in fibrosis using genetically engineered mice as model systems. Dr. Roberto Pezza trained at the NIH. He will investigate molecular mechanisms of DNA strand invasion during homologous recombination in meiosis using purified proteins, cell lines, and murine models. Dr. Chris Sansam came to OMRF recently from MIT. He will study mechanisms of DNA repair during mitosis, both during normal development and also after chemotherapy, using cell lines and zebrafish. Dr. Weidong Wang came from iPierian, a biotech company in California. He will develop methods to produce human pancreatic beta cells from induced pluripotent stem cells for treatment of patients with type 1 diabetes. Each Junior Investigator will be assigned two or three mentors, one of whom will be their Program Head. They will also receive feedback and mentoring from an outstanding External Advisory Committee comprised of Drs. Max Cooper (Chair), Nicholas Dysan, Eric Olson, and Patricia Hunt, The Junior Investigators will be supported by four Cores: an Administrative Core, a Bioinformatics and Pathways Core, a Flow Cytometry Core, and an Imaging Core. A monthly seminar series will be initiated to facilitate interactions among the Junior Investigators who are united by common scientific interests, experimental approaches, and bioinformatics challenges. The establishment of this COBRE will promote the careers of these young scientists, encourage multidisciplinary research in Developmental Biology, and build infrastructure that will benefit OMRF and the entire scientific enterprise of the state of Oklahoma.