Expanding Excellence in Developmental Biology in Oklahoma

描述（由申请人提供）：该 COBRE（在俄克拉荷马州扩大发育生物学卓越）将支持五名才华横溢、训练有素的新聘初级研究员，他们在发育生物学的不同领域工作。 Hui-Ying Lim 博士来自伯纳姆研究所。她将研究活性氧对果蝇心脏发育和功能的调节。 Lorin Olson 博士在西奈山完成博士后研究后来到 OMRF。他将使用基因工程小鼠作为模型系统来研究 PDGF 受体在纤维化中的作用。 Roberto Pezza 博士曾在 NIH 接受过培训。他将使用纯化的蛋白质、细胞系和小鼠模型研究减数分裂同源重组过程中 DNA 链入侵的分子机制。 Chris Sansam 博士最近从麻省理工学院来到 OMRF。他将使用细胞系和斑马鱼研究有丝分裂期间的 DNA 修复机制，包括正常发育期间和化疗后。王卫东博士来自加州生物科技公司iPierian。他将开发利用诱导多能干细胞生产人类胰腺β细胞的方法，用于治疗1型糖尿病患者。每个初级研究员将被分配两到三名导师，其中一名将担任他们的项目负责人。他们还将收到由博士组成的杰出外部咨询委员会的反馈和指导。初级研究者 Max Cooper（主席）、Nicholas Dysan、Eric Olson 和 Patricia Hunt 将得到四个核心的支持：管理核心、生物信息学和通路核心、流式细胞术核心和成像核心。将启动每月一次的研讨会系列，以促进因共同的科学兴趣、实验方法和生物信息学挑战而团结在一起的初级研究人员之间的互动。 COBRE 的建立将促进这些年轻科学家的职业生涯，鼓励发育生物学的多学科研究，并建设有利于 OMRF 和俄克拉荷马州整个科学事业的基础设施。

DESCRIPTION (provided by applicant): This COBRE, Expanding Excellence in Developmental Biology in Oklahoma, will support five extremely talented, well-trained, newly-hired Junior Investigators working in diverse areas of Developmental Biology. Dr. Hui-Ying Lim comes to us from the Burnham Institute. She will investigate the regulation of cardiac development and function by reactive oxygen species in Drosophila. Dr. Lorin Olson arrived at OMRF after post-doctoral studies at Mt. Sinai. He will study the role of PDGF receptors in fibrosis using genetically engineered mice as model systems. Dr. Roberto Pezza trained at the NIH. He will investigate molecular mechanisms of DNA strand invasion during homologous recombination in meiosis using purified proteins, cell lines, and murine models. Dr. Chris Sansam came to OMRF recently from MIT. He will study mechanisms of DNA repair during mitosis, both during normal development and also after chemotherapy, using cell lines and zebrafish. Dr. Weidong Wang came from iPierian, a biotech company in California. He will develop methods to produce human pancreatic beta cells from induced pluripotent stem cells for treatment of patients with type 1 diabetes. Each Junior Investigator will be assigned two or three mentors, one of whom will be their Program Head. They will also receive feedback and mentoring from an outstanding External Advisory Committee comprised of Drs. Max Cooper (Chair), Nicholas Dysan, Eric Olson, and Patricia Hunt, The Junior Investigators will be supported by four Cores: an Administrative Core, a Bioinformatics and Pathways Core, a Flow Cytometry Core, and an Imaging Core. A monthly seminar series will be initiated to facilitate interactions among the Junior Investigators who are united by common scientific interests, experimental approaches, and bioinformatics challenges. The establishment of this COBRE will promote the careers of these young scientists, encourage multidisciplinary research in Developmental Biology, and build infrastructure that will benefit OMRF and the entire scientific enterprise of the state of Oklahoma.