Expanding Excellence in Developmental Biology in Oklahoma

扩大俄克拉荷马州发育生物学的卓越水平

• 批准号: 8432235
• 负责人: Linda F Thompson
• 金额: $ 282万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8432235
• 关键词: Address; Advisory Committees; Age; Animal Model; Appointment; Area; Award; Bioinformatics; Biological Models; Biomedical Research; California; Cardiac; Cardiovascular Diseases; Cardiovascular system; Cell Line; Centers of Research Excellence; Communities; Conflict (Psychology); Congenital Abnormality; Core Facility; DNA; DNA Repair; Development; Developmental Biology; Diabetes Mellitus; Discipline; Disease; Dropout; Drosophila genus; Environment; Epigenetic Process; Faculty; Feedback; Fertilization; Fibrosis; Flow Cytometry; Genes; Genetically Engineered Mouse; Genome; Head; Health; Hematopoietic stem cells; Human; Image; Immune system; Infertility; Infusion procedures; Institutes; Institution; Insulin-Dependent Diabetes Mellitus; Interdisciplinary Study; Journals; Knowledge; Lead; Malignant Neoplasms; Meiosis; Mentors; Methods; Mitosis; Modeling; Molecular; Mus; Oklahoma; Pathway interactions; Patients; Physiological Processes; Platelet-Derived Growth Factor Receptor; Positioning Attribute; Postdoctoral Fellow; Prevention; Proteins; Publications; Publishing; Reactive Oxygen Species; Recruitment Activity; Regenerative Medicine; Regulation; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Role; Scientist; Series; Structure of beta Cell of islet; System; Systems Development; Technology; Time; Training; Translating; United States National Institutes of Health; Work; Zebrafish; career; chemotherapy; fly; homologous recombination; human disease; induced pluripotent stem cell; interest; member; programs; protein function; public health relevance; small molecule; tool; treatment strategy; trend

DESCRIPTION (provided by applicant): This COBRE, Expanding Excellence in Developmental Biology in Oklahoma, will support five extremely talented, well-trained, newly-hired Junior Investigators working in diverse areas of Developmental Biology. Dr. Hui-Ying Lim comes to us from the Burnham Institute. She will investigate the regulation of cardiac development and function by reactive oxygen species in Drosophila. Dr. Lorin Olson arrived at OMRF after post-doctoral studies at Mt. Sinai. He will study the role of PDGF receptors in fibrosis using genetically engineered mice as model systems. Dr. Roberto Pezza trained at the NIH. He will investigate molecular mechanisms of DNA strand invasion during homologous recombination in meiosis using purified proteins, cell lines, and murine models. Dr. Chris Sansam came to OMRF recently from MIT. He will study mechanisms of DNA repair during mitosis, both during normal development and also after chemotherapy, using cell lines and zebrafish. Dr. Weidong Wang came from iPierian, a biotech company in California. He will develop methods to produce human pancreatic beta cells from induced pluripotent stem cells for treatment of patients with type 1 diabetes. Each Junior Investigator will be assigned two or three mentors, one of whom will be their Program Head. They will also receive feedback and mentoring from an outstanding External Advisory Committee comprised of Drs. Max Cooper (Chair), Nicholas Dysan, Eric Olson, and Patricia Hunt, The Junior Investigators will be supported by four Cores: an Administrative Core, a Bioinformatics and Pathways Core, a Flow Cytometry Core, and an Imaging Core. A monthly seminar series will be initiated to facilitate interactions among the Junior Investigators who are united by common scientific interests, experimental approaches, and bioinformatics challenges. The establishment of this COBRE will promote the careers of these young scientists, encourage multidisciplinary research in Developmental Biology, and build infrastructure that will benefit OMRF and the entire scientific enterprise of the state of Oklahoma.

描述（由申请人提供）：这个眼镜蛇，在俄克拉荷马州发展生物学扩展卓越，将支持五个非常有才华，训练有素，新聘请的初级研究员在发展生物学的不同领域工作。林惠英博士来自伯纳姆研究所。她将研究果蝇中活性氧对心脏发育和功能的调节。洛林奥尔森抵达OMRF后，在山博士后研究。西奈他将使用基因工程小鼠作为模型系统研究PDGF受体在纤维化中的作用。Roberto Pezza博士在NIH接受过培训。他将使用纯化的蛋白质、细胞系和小鼠模型研究减数分裂中同源重组过程中DNA链侵入的分子机制。Chris Sansam博士最近从MIT来到OMRF。他将使用细胞系和斑马鱼研究有丝分裂期间DNA修复的机制，包括正常发育期间和化疗后。王卫东博士来自加州的一家生物技术公司iPierian。他将开发从诱导多能干细胞生产人类胰腺β细胞的方法，用于治疗1型糖尿病患者。每个初级研究员将被分配两个或三个导师，其中一个将是他们的项目负责人。他们还将收到由Max库珀博士（主席）、Nicholas Dysan、Eric Olson和Patricia Hunt组成的杰出外部咨询委员会的反馈和指导。初级研究者将得到四个核心的支持：行政核心、生物信息学和途径核心、流式细胞术核心和成像核心。将启动每月一次的研讨会系列，以促进初级研究人员之间的互动，他们通过共同的科学兴趣，实验方法和生物信息学挑战而团结起来。该COBRE的建立将促进这些年轻科学家的职业生涯，鼓励发育生物学的多学科研究，并建立有利于OMRF和俄克拉荷马州整个科学事业的基础设施。