How satiation control reward value and cue-induced appetitive behaviours

饱足感如何控制奖励价值和提示诱发的食欲行为

• 批准号: DP210103929
• 负责人: Dr Zhi Yi Ong
• 金额: $ 30.81万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103929
• 关键词: How; satiation; control; reward; value

This proposal aims to identify mechanisms that control environment-driven food-seeking behaviours. It seeks to do so by using modern virally-mediated and basic behavioural as well as histological techniques in a transgenic rat to characterise novel hindbrain circuits that control these feeding behaviours. This is significant as environment-driven overeating is problematic yet underlying mechanisms are unclear. This project expects to provide new knowledge on when, where and how hindbrain neurons control environment-driven food-seeking behaviours. This should provide benefits to the advancement of knowledge on the neural mechanisms of food-seeking and provide a basic science platform for future research on the study of feeding behaviours.

该提案旨在确定控制环境驱动的觅食行为的机制。它试图通过在转基因大鼠中使用现代病毒介导的和基本的行为以及组织学技术来实现这一目标，以建立控制这些进食行为的新的后脑回路。这是重要的，因为环境驱动的暴饮暴食是有问题的，但潜在的机制尚不清楚。该项目希望提供关于后脑神经元何时、何地以及如何控制环境驱动的寻食行为的新知识。这将有助于提高对食物寻求神经机制的认识，并为未来研究摄食行为提供基础科学平台。