Gut-brain control of cue-induced feeding behaviours

肠脑对提示诱导的进食行为的控制

• 批准号: FT220100711
• 负责人: Dr Zhi Yi Ong
• 金额: $ 56.45万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT220100711
• 关键词: Gut; brain; control; cue; induced

This proposal aims to determine how food cues (e.g., advertisements) trigger our desire to eat. Using modern virally-mediated strategies, behavioural and histological techniques in a transgenic rat, this proposal seeks to characterise novel gut-brain circuits that mediate cue-induced feeding behaviours. This is significant as food cues can cause overeating, which is problematic in the current obesogenic society, yet the mechanisms are unclear. This project expects to provide new knowledge on how the gut communicates with multiple brain regions to control cue-induced eating. This work should benefit the advancement of knowledge and establish a framework for future research on gut-brain mechanisms in cue-induced feeding.

这一提议旨在确定食物线索（如广告）如何引发我们的食欲。利用现代病毒介导策略、行为和组织学技术，在转基因大鼠中，本建议寻求表征介导线索诱导的摄食行为的新型肠-脑回路。这一点很重要，因为食物线索会导致暴饮暴食，这在当前的致肥社会是一个问题，但其机制尚不清楚。该项目希望为肠道如何与多个大脑区域沟通以控制线索诱导进食提供新的知识。这项工作将有助于知识的进步，并为进一步研究线索诱导进食的肠-脑机制建立框架。