Center for Pacific Innovations, Knowledge, and Opportunities (PIKO)

太平洋创新、知识和机会中心(PIKO)将在全州范围内建立 改善太平洋土著人民(IPP)健康的翻译研究(CTR)基础设施--定义为 夏威夷原住民、其他太平洋岛民和菲律宾人。IPP占夏威夷人口的40%，并拥有 与白人和亚洲人相比，身体和精神健康状况的比率高得不成比例。他们 也构成了夏威夷其他医疗服务不足和弱势群体的大部分。Piko代表着 夏威夷大学(牵头)、夏威夷太平洋大学、查米纳德大学 火奴鲁鲁，以及全州实践组织网络(PBO)和社区组织 (CBO)。Piko强调了CTR的T3(功效研究)到T5(采用和制度化)领域 在那里，健康的社会决定因素具有很强的作用。Piko采用团队科学的方法来实现转型 目前的CTR模式，并加快CTR的进展，以改善IPP的健康。Piko由七个核心组成： 行政管理；专业发展；试点项目计划；生物统计学、流行病学和研究 设计；社区参与和外联；临床研究和监管支持；以及跟踪和 评估。夏威夷大学承诺在5年内为PIKO提供200万美元。总体的具体目标是： 具体目标1：通过在以下方面建立和实施CTR活动，建立一个强大的CTR基础设施 以及跨PIKO合作机构；通过利用其他研究基础设施的资源和专业知识 计划；通过创建学术导师、社区领袖、初级调查人员和研究的CTR注册 通过实施高效和有效的行政业务和沟通战略。 具体目标2：通过确定IPP和非IPP调查员，加强CTR工作人员并使其多样化 对于CTR职业；通过加强CTR调查人员和社区的指导和专业发展 通过支持具有文化响应性和科学价值的CTR试点项目；并通过参与 PBO/CBO积极参与CTR的各个方面。 具体目标3：通过在以下方面提供战略投资，传播和实施反恐审查结果 PBO/CBO加强基于信任的关系；加强全州PBO/CBO网络以服务 作为传播和执行合作伙伴；召开一次年度会议，将CTR 调查人员和PBO/CBO利益相关者分享最佳实践、发现和传播以及 实施战略；并利用数据科学战略传播以下数据和研究结果 用户友好，易于理解，易于访问。 到这个为期5年的项目结束时，PIKO将促进高影响力的变革性CTR，以改善 夏威夷的IPP和其他边缘化社区的健康状况。

The Center for Pacific Innovations, Knowledge, and Opportunities (PIKO) will build a statewide clinical and translational research (CTR) infrastructure to improve the health of Indigenous Pacific People (IPP) – defined as Native Hawaiians, Other Pacific Islanders, and Filipinos. IPP comprise 40% of Hawaii’s population and have disproportionately high rates of physical and mental health conditions compared to Whites and Asians. They also make up a majority of Hawaii’s other medically underserved and vulnerable populations. PIKO represents a partnership between the University of Hawaii (lead), Hawaii Pacific University, Chaminade University of Honolulu, and a statewide network of practice-based organizations (PBO) and community-based organizations (CBO). PIKO emphasizes the T3 (efficacy studies) to T5 (adoption and institutionalization) domains of CTR where the social determinants of health are strongly operative. PIKO takes a team-science approach to transform current CTR paradigms and to accelerate CTR advances to improve IPP health. PIKO comprises seven Cores: Administrative; Professional Development; Pilot Projects Program; Biostatistics, Epidemiology, and Research Design; Community Engagement and Outreach; Clinical Research and Regulatory Support; and Tracking and Evaluation. The University of Hawaii committed $2 million over 5 years to PIKO. The Overall Specific Aims are: Specific Aim 1: Build a robust CTR infrastructure by establishing and implementing CTR activities within and across PIKO partnering institutions; by leveraging resources and expertise of other research infrastructure programs; by creating CTR registries of academic mentors, community leaders, junior investigators, and study participants; and by implementing efficient and effective administrative operations and communication strategies. Specific Aim 2: Strengthen and diversify the CTR workforce by identifying IPP and non-IPP investigators for CTR careers; by enhancing the mentoring and professional development of CTR investigators and community leaders; by supporting culturally responsive and scientifically meritorious CTR pilot projects; and by engaging PBO/CBO to actively participate on all aspects of CTR. Specific Aim 3: Disseminate and implement CTR findings by providing strategic investments in PBO/CBO to strengthen trust-based relationships; by strengthening a statewide network of PBO/CBO to serve as dissemination and implementation partners; by convening an annual conference that brings together CTR investigators and PBO/CBO stakeholders to share best practices, discoveries, and dissemination and implementation strategies; and by leveraging data science strategies to disseminate data and findings that are user-friendly, easy to understand, and accessible. By the end of this 5-year project, PIKO will have promoted high-impact transformative CTR to improve the health of IPP and other marginalized communities in Hawaii.