Strengthening Data Science Capacity for Biomedical Research Advancement at Hawaii

加强夏威夷生物医学研究进展的数据科学能力

• 批准号: 10872087
• 负责人: Joseph Keawe'aimoku Kaholokula
• 金额: $ 39.13万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10872087
• 关键词: Acceleration; Address; Adoption; Affect; Asian population; Biomedical Research; Biometry; Budgets; COVID-19 pandemic; Clinical Investigator; Clinical Research; Communication; Communities; Community Outreach; Data; Data Science; Death Rate; Development; Dissemination and Implementation; Doctor of Philosophy; Economics; Ensure; Environment; Epidemiology; Ethnic Population; Evaluation; Face; Filipino; Fostering; Funding; Hawaii; Hawaiian; Health; Health Personnel; Health Promotion; Homelessness; Human; Indigenous; Institution; Institutionalization; Intervention; Investments; Knowledge; Lead; Left; Life; Longevity; Mental Health; Mentors; Native Hawaiian or Other Pacific Islander; Participant; Personal Satisfaction; Persons; Pilot Projects; Policies; Population; Poverty; Reduce health disparities; Registries; Research; Research Activity; Research Design; Research Infrastructure; Research Personnel; Resources; Rural; Science; Sexual and Gender Minorities; Translational Research; Trust; Underinsured; Underserved Population; Unemployment; Uninsured; United States; United States National Institutes of Health; Universities; Vulnerable Populations; career; clinical development; community engagement; community organizations; disorder prevention; efficacy study; evidence base; health care availability; health disparity; health disparity populations; implementation strategy; improved; innovation; marginalized community; medically underserved population; operation; physical conditioning; programs; racial population; research study; rural area; social health determinants; socioeconomics; success; symposium; underserved community; unhealthy lifestyle; user-friendly

The Center for Pacific Innovations, Knowledge, and Opportunities (PIKO) will build a statewide clinical and translational research (CTR) infrastructure to improve the health of Indigenous Pacific People (IPP) – defined as Native Hawaiians, Other Pacific Islanders, and Filipinos. IPP comprise 40% of Hawaii’s population and have disproportionately high rates of physical and mental health conditions compared to Whites and Asians. They also make up a majority of Hawaii’s other medically underserved and vulnerable populations. PIKO represents a partnership between the University of Hawaii (lead), Hawaii Pacific University, Chaminade University of Honolulu, and a statewide network of practice-based organizations (PBO) and community-based organizations (CBO). PIKO emphasizes the T3 (efficacy studies) to T5 (adoption and institutionalization) domains of CTR where the social determinants of health are strongly operative. PIKO takes a team-science approach to transform current CTR paradigms and to accelerate CTR advances to improve IPP health. PIKO comprises seven Cores: Administrative; Professional Development; Pilot Projects Program; Biostatistics, Epidemiology, and Research Design; Community Engagement and Outreach; Clinical Research and Regulatory Support; and Tracking and Evaluation. The University of Hawaii committed $2 million over 5 years to PIKO. The Overall Specific Aims are: Specific Aim 1: Build a robust CTR infrastructure by establishing and implementing CTR activities within and across PIKO partnering institutions; by leveraging resources and expertise of other research infrastructure programs; by creating CTR registries of academic mentors, community leaders, junior investigators, and study participants; and by implementing efficient and effective administrative operations and communication strategies. Specific Aim 2: Strengthen and diversify the CTR workforce by identifying IPP and non-IPP investigators for CTR careers; by enhancing the mentoring and professional development of CTR investigators and community leaders; by supporting culturally responsive and scientifically meritorious CTR pilot projects; and by engaging PBO/CBO to actively participate on all aspects of CTR. Specific Aim 3: Disseminate and implement CTR findings by providing strategic investments in PBO/CBO to strengthen trust-based relationships; by strengthening a statewide network of PBO/CBO to serve as dissemination and implementation partners; by convening an annual conference that brings together CTR investigators and PBO/CBO stakeholders to share best practices, discoveries, and dissemination and implementation strategies; and by leveraging data science strategies to disseminate data and findings that are user-friendly, easy to understand, and accessible. By the end of this 5-year project, PIKO will have promoted high-impact transformative CTR to improve the health of IPP and other marginalized communities in Hawaii.

太平洋创新、知识和机会中心 (PIKO) 将建立一个全州范围的临床和 改善太平洋原住民 (IPP) 健康的转化研究 (CTR) 基础设施 – 定义为 夏威夷原住民、其他太平洋岛民和菲律宾人。 IPP 占夏威夷人口的 40%， 与白人和亚洲人相比，身体和心理健康问题的比例高得不成比例。他们 夏威夷其他医疗服务不足和弱势群体也占大多数。 PIKO代表 夏威夷大学（牵头）、夏威夷太平洋大学、查米纳德大学之间的合作伙伴关系 檀香山，以及全州范围内的实践组织 (PBO) 和社区组织网络 （国会预算办公室）。 PIKO 强调 CTR 的 T3（功效研究）到 T5（采用和制度化）领域 健康的社会决定因素发挥着重要作用。 PIKO 采用团队科学方法进行转型 当前的 CTR 范例并加速 CTR 进步以改善 IPP 健康状况。 PIKO 包含七个核心： 行政;专业发展；试点项目计划；生物统计学、流行病学和研究 设计;社区参与和外展；临床研究和监管支持；和跟踪和 评估。夏威夷大学在 5 年内向 PIKO 投入 200 万美元。总体具体目标是： 具体目标 1：通过在内部建立和实施 CTR 活动来构建强大的 CTR 基础设施 以及 PIKO 合作机构；通过利用其他研究基础设施的资源和专业知识 节目；通过创建学术导师、社区领袖、初级研究者和研究的 CTR 登记册 参与者；并实施高效且有效的行政运作和沟通策略。 具体目标 2：通过确定 IPP 和非 IPP 调查员来加强 CTR 员工队伍并使其多样化 对于 CTR 职业；通过加强 CTR 研究人员和社区的指导和专业发展 领导者；通过支持具有文化敏感性和科学价值的 CTR 试点项目；并通过参与 PBO/CBO 积极参与 CTR 的各个方面。 具体目标 3：通过提供战略投资来传播和实施点击率调查结果 PBO/CBO 加强基于信任的关系；通过加强 PBO/CBO 的全州网络来服务 作为传播和实施伙伴；通过召开 CTR 年度会议 研究人员和 PBO/CBO 利益相关者分享最佳实践、发现和传播 实施策略；并利用数据科学策略来传播数据和研究结果 用户友好、易于理解且易于访问。 到这个 5 年项目结束时，PIKO 将推广具有高影响力的变革性点击率，以提高 IPP 和夏威夷其他边缘化社区的健康。

项目成果

Identification and Implications of HIV-1 CRF01_AE Subtype in Hawai'i.

• 发表时间: 2022-08
• 期刊: Hawai'i journal of health & social welfare
• 作者: Logan S. Dean;I. SahBandar;C. Shikuma

Wellbeing for all: Indigenizing theories and measures of wellbeing for equitable sustainability.

• DOI: 10.3389/fpsyg.2022.979109
• 发表时间: 2022
• 期刊: FRONTIERS IN PSYCHOLOGY
• 影响因子: 3.8
• 作者: Qina'au, Joanne;Antonio, Mapuana C. K.
• 通讯作者: Antonio, Mapuana C. K.

Living Well With Kidney Disease and Effective Symptom Management: Consensus Conference Proceedings.

• DOI: 10.1016/j.ekir.2022.06.015
• 发表时间: 2022-09
• 期刊: KIDNEY INTERNATIONAL REPORTS
• 影响因子: 6
• 作者: Rhee, Connie M.;Edwards, Dawn;Ahdoot, Rebecca S.;Burton, James O.;Conway, Paul T.;Fishbane, Steven;Gallego, Daniel;Gallieni, Maurizio;Gedney, Nieltje;Hayashida, Glen;Ingelfinger, Julie;Kataoka-Yahiro, Merle;Knight, Richard;Kopple, Joel D.;Kumarsawami, Latha;Lockwood, Mark B.;Murea, Mariana;Page, Victoria;Sanchez, J. Emilio;Szepietowski, Jacek C.;Lui, Siu-Fai;Kalantar-Zadeh, Kamyar
• 通讯作者: Kalantar-Zadeh, Kamyar

Cost Effectiveness of a Cultural Physical Activity Intervention to Reduce Blood Pressure Among Native Hawaiians with Hypertension.

• DOI: 10.1007/s41669-021-00291-6
• 发表时间: 2022-01
• 期刊: PharmacoEconomics - open
• 作者: Railey AF;Muller C;Noonan C;Schmitter-Edgecombe M;Sinclair K;Kim C;Look M;Kaholokula JK
• 通讯作者: Kaholokula JK

A Report on the Impact of the COVID-19 Pandemic on the Health and Social Welfare of the Native Hawaiian Population in Hawai'i.

关于 COVID-19 大流行对夏威夷原住民健康和社会福利影响的报告。

• 发表时间: 2021
• 期刊: Hawai'i journal of health & social welfare
• 作者: Palakiko,Donna-Marie;Daniels,Sheri-Ann;Haitsuka,Kilohana;DeFries,Kai'olu;Kamakawiwo'ole,Sarah;Tolentino,NKu'uleimomi;Buenconsejo-Lum,LeeE;Palafox,NealA;Zhi,Qi;Qureshi,Kristine
• 通讯作者: Qureshi,Kristine