Center for Pacific Innovations, Knowledge, and Opportunities (PIKO)

太平洋创新，知识和机会中心（PIKO）将建立一个全州范围的临床和 转化研究（CTR）基础设施，以改善土著太平洋人民（IPP）的健康-定义为 夏威夷原住民、其他太平洋岛民和菲律宾人。IPP占夏威夷人口的40%， 与白人和亚洲人相比，身体和精神健康状况不成比例地高。他们 也是夏威夷其他医疗服务不足和脆弱人群的主要组成部分。PIKO代表 夏威夷大学（牵头）、夏威夷太平洋大学、 檀香山，以及全州范围的实践组织和社区组织网络 （CBO）. PIKO强调CTR的T3（疗效研究）到T5（采用和制度化）领域 健康的社会决定因素发挥着重要作用。PIKO采用团队科学的方法来改造 目前的CTR范例，并加快CTR的进步，以改善IPP的健康。PIKO由七个核心组成： 管理;专业发展;试点项目计划;生物统计学，流行病学和研究 设计;社区参与和外联;临床研究和监管支持;以及跟踪和 评价夏威夷大学承诺在5年内向PIKO提供200万美元。总体具体目标是： 具体目标1：通过在内部建立和实施CTR活动，建立强大的CTR基础设施 和PIKO合作机构之间;通过利用其他研究基础设施的资源和专业知识 项目;通过创建学术导师、社区领袖、初级研究人员和研究人员的CTR注册表， 参与者;以及实施高效和有效的行政运作和沟通战略。 具体目标2：通过确定IPP和非IPP调查员，加强CTR工作队伍并使其多样化 对于CTR职业;通过加强CTR调查人员和社区的指导和专业发展 领导人;通过支持文化上敏感和科学上有价值的合作减少风险试点项目;并通过参与 PBO/CBO积极参与CTR的各个方面。 具体目标3：通过提供战略投资， PBO/CBO加强以信任为基础的关系;通过加强PBO/CBO的全州网络， 作为传播和执行伙伴;召开年度会议， 调查人员和PBO/CBO利益相关者分享最佳实践、发现和传播， 实施战略;并通过利用数据科学战略来传播 用户友好、易于理解和可访问。 在这个为期5年的项目结束时，PIKO将促进高影响力的变革性CTR，以改善 在夏威夷的IPP和其他边缘化社区的健康。

The Center for Pacific Innovations, Knowledge, and Opportunities (PIKO) will build a statewide clinical and translational research (CTR) infrastructure to improve the health of Indigenous Pacific People (IPP) – defined as Native Hawaiians, Other Pacific Islanders, and Filipinos. IPP comprise 40% of Hawaii’s population and have disproportionately high rates of physical and mental health conditions compared to Whites and Asians. They also make up a majority of Hawaii’s other medically underserved and vulnerable populations. PIKO represents a partnership between the University of Hawaii (lead), Hawaii Pacific University, Chaminade University of Honolulu, and a statewide network of practice-based organizations (PBO) and community-based organizations (CBO). PIKO emphasizes the T3 (efficacy studies) to T5 (adoption and institutionalization) domains of CTR where the social determinants of health are strongly operative. PIKO takes a team-science approach to transform current CTR paradigms and to accelerate CTR advances to improve IPP health. PIKO comprises seven Cores: Administrative; Professional Development; Pilot Projects Program; Biostatistics, Epidemiology, and Research Design; Community Engagement and Outreach; Clinical Research and Regulatory Support; and Tracking and Evaluation. The University of Hawaii committed $2 million over 5 years to PIKO. The Overall Specific Aims are: Specific Aim 1: Build a robust CTR infrastructure by establishing and implementing CTR activities within and across PIKO partnering institutions; by leveraging resources and expertise of other research infrastructure programs; by creating CTR registries of academic mentors, community leaders, junior investigators, and study participants; and by implementing efficient and effective administrative operations and communication strategies. Specific Aim 2: Strengthen and diversify the CTR workforce by identifying IPP and non-IPP investigators for CTR careers; by enhancing the mentoring and professional development of CTR investigators and community leaders; by supporting culturally responsive and scientifically meritorious CTR pilot projects; and by engaging PBO/CBO to actively participate on all aspects of CTR. Specific Aim 3: Disseminate and implement CTR findings by providing strategic investments in PBO/CBO to strengthen trust-based relationships; by strengthening a statewide network of PBO/CBO to serve as dissemination and implementation partners; by convening an annual conference that brings together CTR investigators and PBO/CBO stakeholders to share best practices, discoveries, and dissemination and implementation strategies; and by leveraging data science strategies to disseminate data and findings that are user-friendly, easy to understand, and accessible. By the end of this 5-year project, PIKO will have promoted high-impact transformative CTR to improve the health of IPP and other marginalized communities in Hawaii.