Joint Biology Consortium Resource-based Center

项目总结/摘要-总体 打破转化研究的障碍是找到治疗炎症性关节炎新方法的关键 以及成人和儿童的相关疾病。四年前，在P30的支持下，我们建立了联合生物学， Consortium（JBC），一个位于Brigham and Women's Hospital和Boston Children's Hospital的共享基础设施。 医院，以加速以关节炎为重点的研究社区的工作，目前已涵盖18项研究 在美国和国外的中心。基于JBC的成功，我们建议继续并 扩展围绕JBC成员共同需求设计的三个核心的基本设计， 提高现有研究的效率，促进创新，培养初级研究人员。 1.行政核心是JBC的组织核心，协调业务并培养 JBC研究网络的科学潜力，通过JBC门户网站进行协调。JBC Synergy 会议和访问教授计划促进科学交流，JBC劳动力发展 集团促进多元化和包容性的研究管道，和JBC丰富计划纳入 来自获奖导师的创新，通过赠款目标审查，指导， 以及每年12笔5 000美元的JBC小额赠款，以促进利用JBC的服务进行试点和可行性研究。 2.人类生物样本核心为成人和儿童生物样本提供“一站式购物”， 关节炎及相关疾病的研究。HBC利用了19个不同的样本来源。新JBC Recruitment Core从超过100，000名同意的个人中提供有针对性的前瞻性招聘， 在许多情况下，基因型，以建立一个统一的管道，在整个生命周期的生物标本。 3.细胞系统核心为关节炎研究提供了资源和专业知识密集型工具。下一个- 第二代测序工具包括单细胞RNAseq、CITE-seq、ATAC-seq、T-scan、PhIP-seq和空间测序。 转录组学，而基于蛋白质的服务包括CyTOF，组织质量细胞术和定制Luminex，所有 在新的JBC生物信息学核心的帮助和教育下进行分析。 由忠诚的研究人员和导师带头PI/PD主任Peter Nigrovic博士和助理 董事兼联合PI伊丽莎白·卡尔森博士，JBC在一个故意包容和高度 高级和初级研究人员的协作网络，使联合生物学联盟能够继续 发展成为成人和小儿关节炎及相关疾病转化研究的引擎。

PROJECT SUMMARY/ABSTRACT - Overall Breaking down barriers to translational research is the key to finding new approaches to inflammatory arthritis and related diseases in adults and children. Four years ago, with P30 support, we built the Joint Biology Consortium (JBC), a shared infrastructure based at the Brigham and Women’s Hospital and Boston Children’s Hospital, to accelerate the work of an arthritis-focused Research Community now spanning 18 research centers across the United States and abroad. Based on the success of the JBC, we propose to continue and expand the fundamental design of three Cores designed around the shared needs of JBC members to enhance the efficiency of existing studies, facilitate innovation, and foster junior investigators. 1. The Administrative Core is the organizational heart of the JBC, coordinating operations and cultivating the scientific potential of the JBC research network, coordinated through the JBC Web Portal. The JBC Synergy Meeting and Visiting Professor program promote scientific interchange, the JBC Workforce Development Group promotes a diverse and inclusive research pipeline, and the JBC Enrichment Program incorporates innovations from award-winning mentors to support JBC Young Investigators via grant aims review, mentoring, and 12 yearly JBC Microgrants of $5,000 to facilitate utilization of JBC services for pilot and feasibility studies. 2. The Human Biosamples Core provides “one-stop shopping” for adult and pediatric biospecimens essential to research in arthritis and related diseases. The HBC leverages 19 distinct sources of samples. The new JBC Recruitment Core provides targeted prospective recruitment from over 100,000 consented individuals based on phenotype and, in many cases, genotype to build a unified pipeline for biospecimens across the lifespan. 3. The Cellular Systems Core provides resource- and expertise-intensive tools for arthritis research. Next- generation sequencing tools include single-cell RNAseq, CITE-seq, ATAC-seq, T-scan, PhIP-seq, and spatial transcriptomics, while protein-based services include CyTOF, tissue mass cytometry, and custom Luminex, all analyzed with assistance and education from the new JBC Bioinformatics Core. Spearheaded by committed investigators and mentors Director PI/PD Dr. Peter Nigrovic and Associate Director and Co-PI Dr. Elizabeth Karlson, the JBC spurs innovation within a deliberately inclusive and highly collaborative network of senior and junior investigators, enabling the Joint Biology Consortium to continue to grow as an engine of translational research in adult and pediatric arthritis and related disease.