Human Biosamples Core

项目总结/摘要-资源核心1：人类生物样本核心 获得新鲜的、仔细分型的人类样本是联合国面临的最艰巨的后勤障碍 生物学联盟（JBC）研究社区。人类生物样本核心克服了这一障碍， 整合波士顿布莱根妇女医院（BWH）现有资源的“系统解决方案” 儿童医院（BCH）和附属机构，拥有一支生物信息学先进的人员团队， 支持样本识别、患者招募、样本处理、数据管理和统计 分析.独特的优势包括儿童和成人患者样本的非凡范围;核心 在尖端转化研究、生物银行和电子健康记录（EHR）方面拥有专业知识的领导力 询问;生物信息学和生物统计学;以及获得健康对照以及患有 比较疾病。这一使命将通过两个具体目标来实现。 目的I帮助JBC成员从16个不同的已建立的生物样本库中识别和获取相关的存档生物样本。 来源，范围从马萨诸塞州总布里格姆（MGB）生物库中的> 120，000名患者到高度专业化的 常见和罕见风湿性疾病以及相关对照的集合。例子包括登记册 类风湿性关节炎（BRASS）、银屑病关节炎（COPPAR）和系统性红斑狼疮（SYLVER）; BCH和CARRA的青少年发病性风湿病生物库;检查点通道诱导的风湿性关节炎 疾病;和来自阿姆斯特丹关节炎银行以及当地档案馆的滑膜组织。 Aim II通过JBC招聘核心提供有针对性的前瞻性招聘， 团队识别、联系、同意、获取和处理与JBC成员会面的患者的样本 规范.供体包括> 120，000名MGB生物库患者，包括> 45，000名具有基因型数据的患者，BWH 和BCH风湿病诊所，正在进行的临床试验和其他来源。 由专家类风湿关节炎调查员和方法学家伊丽莎白卡尔森博士领导， BWH的Jeffrey Sparks博士，BCH的Lauren亨德森博士和Deepak Rao博士 BWH人类免疫学中心进行样本处理，人类生物样本核心代表了一个统一的 生物标本管道加速炎症性关节炎和相关疾病的假设驱动研究 多中心JBC网络的研究者。

PROJECT SUMMARY/ABSTRACT – Resource Core 1: Human Biosamples Core Obtaining fresh, carefully phenotyped human samples is the most daunting logistical hurdle facing the Joint Biology Consortium (JBC) Research Community. The Human Biosamples Core overcomes this barrier with a “systems solution” that integrates existing resources at the Brigham and Women’s Hospital (BWH), Boston Children’s Hospital (BCH), and affiliated institutions with a bioinformatically-sophisticated team of personnel to support sample identification, patient recruitment, sample processing, data management, and statistical analysis. Unique strengths include an extraordinary range of patient samples, both pediatric and adult; core leadership with expertise in cutting-edge translational research, biobanking, and electronic health record (EHR) interrogation; bioinformatics and biostatistics; and access to healthy controls as well as patients with comparator diseases. This mission will be realized through two Specific Aims. Aim I helps JBC members identify and obtain relevant archived biosamples from 16 different established sources, ranging from >120,000 patients in the Mass General Brigham (MGB) Biobank to highly specialized collections from common and rare rheumatic diseases as well as relevant controls. Examples include registries of rheumatoid arthritis (BRASS), psoriatic arthritis (COPPAR), and systemic lupus erythematosus (SYLVER); juvenile-onset rheumatic disease biobanks at BCH and CARRA; checkpoint inhibitor-induced rheumatic diseases; and synovial tissue from the Amsterdam Arthritis Bank as well as local archives. Aim II provides targeted, prospective recruitment via the JBC Recruitment Core, through which a dedicated team identifies, contacts, consents, obtains, and processes samples from patients meeting JBC member specifications. Donors include >120,000 MGB Biobank patients, including >45,000 with genotype data, BWH and BCH rheumatology clinics, ongoing clinical trials, and other sources. Led by expert rheumatoid arthritis investigator and methodologist Dr. Elizabeth Karlson, supported by associate directors Dr. Jeffrey Sparks at BWH, Dr. Lauren Henderson at BCH, and Dr. Deepak Rao heading the BWH Human Immunology Center for sample processing, the Human Biosamples Core represents a unified biospecimen pipeline to accelerate hypothesis-driven research into inflammatory arthritis and related diseases for investigators across the multicenter JBC network.