Human Biosamples Core

项目摘要/摘要--资源核心1：人体生物样本核心 获取新鲜的、仔细的表型鉴定的人体样本是联合医院面临的最艰巨的后勤障碍 生物联盟(JBC)研究社区。人类生物样本核心克服了这一障碍 整合波士顿布里格姆妇女医院(BWH)现有资源的“系统解决方案” 儿童医院(BCH)及其附属机构拥有一支生物信息尖端团队，以 支持样本识别、患者招募、样本处理、数据管理和统计 分析。独特的优势包括非常广泛的儿童和成人患者样本；核心 在尖端翻译研究、生物库和电子健康记录(EHR)方面拥有专业知识的领导力 审问；生物信息学和生物统计学；获得健康对照以及 比较性疾病。这一使命将通过两个具体目标来实现。 目的I帮助JBC成员识别和获取来自16个不同国家的相关存档生物样本 来源：从麻省理工学院普通布里格姆(MGB)生物库的120,000名患者到高度专业化的患者 收集常见和罕见的风湿病以及相关对照资料。示例包括注册表 类风湿性关节炎(黄铜)、银屑病关节炎(COPPAR)和系统性红斑狼疮(Sylver)； BCH和CARA的青少年风湿病生物库；检查点抑制物诱导的风湿病 疾病；以及阿姆斯特丹关节炎银行和当地档案馆的滑膜组织。 AIM II通过JBC招聘核心提供有针对性的预期招聘，通过该核心，专门的 团队识别、联系、同意、获取和处理与JBC成员会面的患者的样本 规格。捐赠者包括&gt；120,000名MGB Biobank患者，其中包括&gt；45,000名具有BWH基因数据的患者 和BCH风湿病诊所、正在进行的临床试验和其他来源。 由风湿性关节炎专家和方法学家伊丽莎白·卡尔森博士领导，由 BWH副主任杰弗里·斯帕克斯博士、BCH劳伦·亨德森博士和迪帕克·拉奥博士领导 BWH人类免疫学样本处理中心，人类生物样本核心代表着一个统一的 Biospecimen流水线加快炎症性关节炎和相关疾病的假说驱动研究 对于跨多中心JBC网络的调查人员。

PROJECT SUMMARY/ABSTRACT – Resource Core 1: Human Biosamples Core Obtaining fresh, carefully phenotyped human samples is the most daunting logistical hurdle facing the Joint Biology Consortium (JBC) Research Community. The Human Biosamples Core overcomes this barrier with a “systems solution” that integrates existing resources at the Brigham and Women’s Hospital (BWH), Boston Children’s Hospital (BCH), and affiliated institutions with a bioinformatically-sophisticated team of personnel to support sample identification, patient recruitment, sample processing, data management, and statistical analysis. Unique strengths include an extraordinary range of patient samples, both pediatric and adult; core leadership with expertise in cutting-edge translational research, biobanking, and electronic health record (EHR) interrogation; bioinformatics and biostatistics; and access to healthy controls as well as patients with comparator diseases. This mission will be realized through two Specific Aims. Aim I helps JBC members identify and obtain relevant archived biosamples from 16 different established sources, ranging from >120,000 patients in the Mass General Brigham (MGB) Biobank to highly specialized collections from common and rare rheumatic diseases as well as relevant controls. Examples include registries of rheumatoid arthritis (BRASS), psoriatic arthritis (COPPAR), and systemic lupus erythematosus (SYLVER); juvenile-onset rheumatic disease biobanks at BCH and CARRA; checkpoint inhibitor-induced rheumatic diseases; and synovial tissue from the Amsterdam Arthritis Bank as well as local archives. Aim II provides targeted, prospective recruitment via the JBC Recruitment Core, through which a dedicated team identifies, contacts, consents, obtains, and processes samples from patients meeting JBC member specifications. Donors include >120,000 MGB Biobank patients, including >45,000 with genotype data, BWH and BCH rheumatology clinics, ongoing clinical trials, and other sources. Led by expert rheumatoid arthritis investigator and methodologist Dr. Elizabeth Karlson, supported by associate directors Dr. Jeffrey Sparks at BWH, Dr. Lauren Henderson at BCH, and Dr. Deepak Rao heading the BWH Human Immunology Center for sample processing, the Human Biosamples Core represents a unified biospecimen pipeline to accelerate hypothesis-driven research into inflammatory arthritis and related diseases for investigators across the multicenter JBC network.