Human Biosamples Core

人体生物样本核心

• 批准号: 10454988
• 负责人: ELIZABETH W KARLSON
• 金额: $ 33.99万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-11 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10454988
• 关键词: Adolescent; Adult; Archives; Arthritis; Bioinformatics; Biology; Biometry; Biopsy; Blood; Body Fluids; Boston; COVID-19; COVID-19 patient; Cancer Patient; Cells; Child; Childhood; Clinic; Clinical Trials; Collection; Communities; Complex; Consent; Consumer Advocates in Research and Related Activities; Data; Data Set; Development; Disease; Electronic Health Record; Faculty; Genotype; Health; Hospitals; Human; Human Resources; Immune checkpoint inhibitor; Immunology; Inflammatory Arthritis; Infrastructure; Institution; Institutional Review Boards; Joints; Leadership; Link; Logistics; Lupus; Medicine; Mission; Online Systems; Oranges; Patient Recruitments; Patients; Pediatric Hospitals; Phenotype; Positioning Attribute; Process; Prospective Studies; Protocols documentation; Psoriatic Arthritis; Quality Control; Registries; Research; Research Personnel; Resources; Rheumatism; Rheumatoid Arthritis; Rheumatology; Sampling; Services; Site; Source; Statistical Data Interpretation; Stream; System; Systemic Lupus Erythematosus; Tissues; Translating; Translational Research; Woman; Work; arthritis registry; base; biobank; biological specimen archives; biomarker identification; cohort; data management; data sharing; experience; flexibility; genomic data; genotyped patients; immune-related adverse events; meetings; member; pediatric patients; pediatric rheumatic diseases; prospective; recruit; sample archive; tissue archive

PROJECT SUMMARY/ABSTRACT – Resource Core 1: Human Biosamples Core Obtaining fresh, carefully phenotyped human samples is the most daunting logistical hurdle facing the Joint Biology Consortium (JBC) Research Community. The Human Biosamples Core overcomes this barrier with a “systems solution” that integrates existing resources at the Brigham and Women’s Hospital (BWH), Boston Children’s Hospital (BCH), and affiliated institutions with a bioinformatically-sophisticated team of personnel to support sample identification, patient recruitment, sample processing, data management, and statistical analysis. Unique strengths include an extraordinary range of patient samples, both pediatric and adult; core leadership with expertise in cutting-edge translational research, biobanking, and electronic health record (EHR) interrogation; bioinformatics and biostatistics; and access to healthy controls as well as patients with comparator diseases. This mission will be realized through two Specific Aims. Aim I helps JBC members identify and obtain relevant archived biosamples from 16 different established sources, ranging from >120,000 patients in the Mass General Brigham (MGB) Biobank to highly specialized collections from common and rare rheumatic diseases as well as relevant controls. Examples include registries of rheumatoid arthritis (BRASS), psoriatic arthritis (COPPAR), and systemic lupus erythematosus (SYLVER); juvenile-onset rheumatic disease biobanks at BCH and CARRA; checkpoint inhibitor-induced rheumatic diseases; and synovial tissue from the Amsterdam Arthritis Bank as well as local archives. Aim II provides targeted, prospective recruitment via the JBC Recruitment Core, through which a dedicated team identifies, contacts, consents, obtains, and processes samples from patients meeting JBC member specifications. Donors include >120,000 MGB Biobank patients, including >45,000 with genotype data, BWH and BCH rheumatology clinics, ongoing clinical trials, and other sources. Led by expert rheumatoid arthritis investigator and methodologist Dr. Elizabeth Karlson, supported by associate directors Dr. Jeffrey Sparks at BWH, Dr. Lauren Henderson at BCH, and Dr. Deepak Rao heading the BWH Human Immunology Center for sample processing, the Human Biosamples Core represents a unified biospecimen pipeline to accelerate hypothesis-driven research into inflammatory arthritis and related diseases for investigators across the multicenter JBC network.

项目摘要/摘要 – 资源核心 1：人类生物样本核心 获得新鲜的、经过仔细表型分析的人类样本是联合组织面临的最艰巨的后勤障碍 生物学联盟 (JBC) 研究社区。人类生物样本核心克服了这一障碍 整合波士顿布莱根妇女医院 (BWH) 现有资源的“系统解决方案” 儿童医院 (BCH) 及其附属机构拥有一支生物信息技术精湛的人员团队， 支持样本识别、患者招募、样本处理、数据管理和统计 分析。独特的优势包括范围广泛的儿童和成人患者样本；核 在尖端转化研究、生物银行和电子健康记录 (EHR) 方面拥有专业知识的领导力 审讯；生物信息学和生物统计学；以及获得健康对照以及患有以下疾病的患者 比较疾病。这一使命将通过两个具体目标来实现。 目标 I 帮助 JBC 成员从 16 个不同的已建立的组织中识别并获取相关的存档生物样本 来源，范围从麻省总医院 (MGB) 生物库中超过 120,000 名患者到高度专业化的患者 常见和罕见风湿病的收集以及相关对照。示例包括注册表 类风湿性关节炎 (BRASS)、银屑病关节炎 (COPPAR) 和系统性红斑狼疮 (SYLVER)； BCH 和 CARRA 的青少年发病风湿病生物库；检查点抑制剂诱导的风湿病 疾病；和来自阿姆斯特丹关节炎银行以及当地档案馆的滑膜组织。 Aim II 通过 JBC 招聘核心提供有针对性的前瞻性招聘，通过该核心，专门的 团队识别、联系、同意、获取和处理与 JBC 成员会面的患者的样本 规格。捐赠者包括 >120,000 名 MGB 生物库患者，其中 >45,000 名具有基因型数据、BWH 和 BCH 风湿病诊所、正在进行的临床试验和其他来源。 由类风湿性关节炎专家调查员和方法学家 Elizabeth Karlson 博士领导，并得到以下机构的支持 BWH 副董事 Jeffrey Sparks 博士、BCH 副董事 Lauren Henderson 博士和 Deepak Rao 博士负责 BWH 人类免疫学中心进行样本处理，人类生物样本核心代表了一个统一的 生物样本管道加速炎症性关节炎及相关疾病的假设驱动研究 供跨多中心 JBC 网络的研究人员使用。