A New England Enrollment Center for PMI Cohort Program

新英格兰 PMI 队列计划招生中心

• 批准号: 9453746
• 负责人: ELIZABETH W KARLSON
• 金额: $ 342.09万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-27 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9453746
• 关键词: Adopted; Adult; Ambulatory Care; Area; Boston; Caring; Catchment Area; Censuses; Clinical Data; Collaborations; Collection; Complement; Consent; Data; Data Reporting; Enrollment; Evaluation; Future; Geography; Goals; Health Personnel; Health Status; Health system; Healthcare Systems; Information Technology; International; Medical center; Minority; Names; Network-based; New England; PMI cohort; Participant; Patient Recruitments; Patients; Performance; Persons; Philosophy; Physicians; Policies; Population; Precision Medicine Initiative; Procedures; Protocols documentation; Recontacts; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Support; Sampling; Services; Shipping; Ships; Structure; Surveys; Target Populations; Teaching Hospitals; Technology; Testing; Universities; base; biobank; clinical infrastructure; cohort; demographics; innovation; medical schools; meetings; programs; sample collection; transmission process; volunteer

We propose the creation of “Precision Medicine Initiative New England” (PMI-NE), an enrollment center that encompasses two leading health care provider (HPO) organizations: Partners HealthCare System (PHS) and Boston Medical Center (BMC), the primary teaching hospital of Boston University School of Medicine (BU). We will provide essential geographic diversity in the Northeast Census Region of the US by complementing the Middle Atlantic Division (NJ, NY, and PA; covered in the Columbia and Pittsburgh PMC HPOs) with the New England Division (CT, ME, MA, NH, RI, and VT). Together, PHS and BMC serve a catchment area of 14.4 million people including a large and diverse proportion of the 4.4 million living in the greater Boston area, large portions of the New England population, and a worldwide referral base. Over a five-year period, PHS and BMC delivered outpatient care to 2,253,618 patients with 863,429 (38%) meeting our recruitment target population criteria. Our organizations have a long history of collaboratively producing and using common, open-standards information technology (IT) that leverages the health care system for discovery and has been adopted nationally and internationally. PHS has already implemented brisk recruitment of patients (more than 46,000 to date, 2,200 consented per month) into the PHS Biobank with many key components of PMI including broad consent, linkage to EMR, electronic surveys, and recontact. In large cutting-edge projects, we have successfully engaged participants as partners in research and sustained longitudinal engagement using traditional as well as innovative IT approaches. As such, we have already developed and tested the IT and clinical infrastructures that will be central to achieving PMI milestones and can rapidly adopt procedures developed by the PMI Consortium. We have an extensive, successful track record of collaboration and contributions to large-scale national networks, including the PCORNet Clinical Data Research Network based at Harvard (named “SCiLHS”) in which PHS and BMC-BU collaborate, eMERGE, and many others (see Past Performance). Our team, comprising diverse stakeholders (physicians, researchers, IT leaders, participants) will cohere to enroll 10,000 patients (46% minority) in service of the PMI Cohort Program (PMI-CP). In the sections that follow, we describe our approach to establishing our PMI-NE HPO and our contributions to the PMI Consortium. We describe well-defined milestones and metrics over the 12-month period of performance.

我们建议创建“新英格兰精准医学计划”(PMI-NE)，这是一个招生中心， 包括两个领先的医疗保健提供商(HPO)组织：合作伙伴医疗保健系统(PHS)和 波士顿医学中心(BMC)，波士顿大学医学院(BU)的主要教学医院。我们 将通过补充美国东北人口普查地区的 中大西洋分部(新泽西州、纽约州和宾夕法尼亚州；哥伦比亚和匹兹堡PMC HPO)与纽约 英格兰赛区(CT、ME、MA、NH、RI和VT)。小灵通和BMC总共为14.4%的集水区提供服务 100万人，其中包括居住在大波士顿地区的440万人中的很大一部分人 新英格兰人口的一部分，以及世界各地的转介基地。在五年期间，PHS和BMC 为2,253,618名患者提供门诊服务，其中863,429名(38%)满足我们的招募目标 人口标准。我们的组织在协作生产和使用公共、 利用医疗保健系统进行发现的开放标准信息技术(IT) 在国内和国际上被采纳。小灵通已经实施了活跃的患者招募(超过 到目前为止，46,000人，每月2,200人同意)进入PHS生物库，PMI的许多关键组成部分包括 广泛同意、与电子病历的联系、电子调查和重新联系。在大型尖端项目中，我们有 成功地让参与者作为研究合作伙伴参与研究和持续的纵向参与 既有传统的，也有创新的IT方法。因此，我们已经开发和测试了IT和 临床基础设施将是实现PMI里程碑的核心，并可以迅速采用程序 由PMI联盟开发。我们拥有广泛、成功的协作记录， 对大型国家网络的贡献，包括基于PCORnet的临床数据研究网络 在哈佛大学(命名为“SCiLHS”)，PHS和BMC-BU合作，出现，以及许多其他的(见过去 性能)。我们的团队，由不同的利益相关者(医生、研究人员、IT领导者、参与者)组成 将联合招募10,000名患者(46%的少数人)参加PMI队列计划(PMI-CP)。在 在接下来的几节中，我们将描述我们建立PMI-NE HPO的方法以及我们对 PMI财团。我们描述了12个月绩效期间明确定义的里程碑和指标。