Joint Biology Consortium Resource-based Center
联合生物学联盟资源中心
基本信息
- 批准号:10454986
- 负责人:
- 金额:$ 89.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-08-11 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:ATAC-seqAdultAntigensArchivesArthritisAwardBioinformaticsBiologyBiometryBostonCRISPR screenCellular Indexing of Transcriptomes and Epitopes by SequencingChildChildhoodCommunitiesConsentConsultationsCountryCustomCytometryDataDiseaseEducationElectronic Health RecordEnsureEnvironmentFeasibility StudiesFosteringGenotypeGrantHealthHeartHospitalsHumanIndividualInflammatory ArthritisInfrastructureInstitutesInvestmentsJointsLeadershipLinkLogisticsLongevityMedicineMentorsMethodologyMethodsModelingNational Institute of Arthritis and Musculoskeletal and Skin DiseasesOrthopedicsPatientsPediatric HospitalsPhage ImmunoPrecipitation SequencingPhenotypePilot ProjectsPositioning AttributeProgram EvaluationProteinsPublicationsResearchResearch PersonnelResourcesReview CommitteeRheumatologySamplingScanningServicesSourceSystemSystemic Lupus ErythematosusTechniquesTechnologyTissuesTranslational ResearchUnited StatesUpdateVisitWomanWorkWorkforce Developmentanalytical toolbasebiobankcareercohortdesigndiversity and inclusioninnovationinterestmeetingsmembernext generation sequencingnovel strategiesoperationprofessorprogramsprospectiveranpirnaserecruitsample collectionservice deliverysingle-cell RNA sequencingstatistical servicesuccesssynergismtooltranscriptomicstranslational scientistweb portal
项目摘要
PROJECT SUMMARY/ABSTRACT - Overall
Breaking down barriers to translational research is the key to finding new approaches to inflammatory arthritis
and related diseases in adults and children. Four years ago, with P30 support, we built the Joint Biology
Consortium (JBC), a shared infrastructure based at the Brigham and Women’s Hospital and Boston Children’s
Hospital, to accelerate the work of an arthritis-focused Research Community now spanning 18 research
centers across the United States and abroad. Based on the success of the JBC, we propose to continue and
expand the fundamental design of three Cores designed around the shared needs of JBC members to
enhance the efficiency of existing studies, facilitate innovation, and foster junior investigators.
1. The Administrative Core is the organizational heart of the JBC, coordinating operations and cultivating the
scientific potential of the JBC research network, coordinated through the JBC Web Portal. The JBC Synergy
Meeting and Visiting Professor program promote scientific interchange, the JBC Workforce Development
Group promotes a diverse and inclusive research pipeline, and the JBC Enrichment Program incorporates
innovations from award-winning mentors to support JBC Young Investigators via grant aims review, mentoring,
and 12 yearly JBC Microgrants of $5,000 to facilitate utilization of JBC services for pilot and feasibility studies.
2. The Human Biosamples Core provides “one-stop shopping” for adult and pediatric biospecimens essential to
research in arthritis and related diseases. The HBC leverages 19 distinct sources of samples. The new JBC
Recruitment Core provides targeted prospective recruitment from over 100,000 consented individuals based
on phenotype and, in many cases, genotype to build a unified pipeline for biospecimens across the lifespan.
3. The Cellular Systems Core provides resource- and expertise-intensive tools for arthritis research. Next-
generation sequencing tools include single-cell RNAseq, CITE-seq, ATAC-seq, T-scan, PhIP-seq, and spatial
transcriptomics, while protein-based services include CyTOF, tissue mass cytometry, and custom Luminex, all
analyzed with assistance and education from the new JBC Bioinformatics Core.
Spearheaded by committed investigators and mentors Director PI/PD Dr. Peter Nigrovic and Associate
Director and Co-PI Dr. Elizabeth Karlson, the JBC spurs innovation within a deliberately inclusive and highly
collaborative network of senior and junior investigators, enabling the Joint Biology Consortium to continue to
grow as an engine of translational research in adult and pediatric arthritis and related disease.
项目摘要/摘要-总体
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ELIZABETH W KARLSON其他文献
ELIZABETH W KARLSON的其他文献
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{{ truncateString('ELIZABETH W KARLSON', 18)}}的其他基金
eMERGE Phase IV Clinical Center at Partners HealthCare
Partners HealthCare 的 eMERGE IV 期临床中心
- 批准号:
10230561 - 财政年份:2020
- 资助金额:
$ 89.32万 - 项目类别:
A New England Enrollment Center for PMI Cohort Program
新英格兰 PMI 队列计划招生中心
- 批准号:
9453746 - 财政年份:2016
- 资助金额:
$ 89.32万 - 项目类别:
A New England Enrollment Center for PMI Cohort Program
新英格兰 PMI 队列计划招生中心
- 批准号:
9355397 - 财政年份:2016
- 资助金额:
$ 89.32万 - 项目类别:
EMERGE PHASE III CLINICAL CENTER AT PARTNERS HEALTHCARE
PARTNERS HEALTHCARE 新兴三期临床中心
- 批准号:
9493516 - 财政年份:2015
- 资助金额:
$ 89.32万 - 项目类别:
eMERGE Phase IV Clinical Center at Mass General Brigham
麻省总医院布里格姆分校 eMERGE IV 期临床中心
- 批准号:
10625354 - 财政年份:2015
- 资助金额:
$ 89.32万 - 项目类别:
EMERGE PHASE III CLINICAL CENTER AT PARTNERS HEALTHCARE
PARTNERS HEALTHCARE 新兴三期临床中心
- 批准号:
9284512 - 财政年份:2015
- 资助金额:
$ 89.32万 - 项目类别:
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