Joint Biology Consortium Resource-based Center

联合生物学联盟资源中心

• 批准号: 10454986
• 负责人: ELIZABETH W KARLSON
• 金额: $ 89.32万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-11 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10454986
• 关键词: ATAC-seq; Adult; Antigens; Archives; Arthritis; Award; Bioinformatics; Biology; Biometry; Boston; CRISPR screen; Cellular Indexing of Transcriptomes and Epitopes by Sequencing; Child; Childhood; Communities; Consent; Consultations; Country; Custom; Cytometry; Data; Disease; Education; Electronic Health Record; Ensure; Environment; Feasibility Studies; Fostering; Genotype; Grant; Health; Heart; Hospitals; Human; Individual; Inflammatory Arthritis; Infrastructure; Institutes; Investments; Joints; Leadership; Link; Logistics; Longevity; Medicine; Mentors; Methodology; Methods; Modeling; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Orthopedics; Patients; Pediatric Hospitals; Phage ImmunoPrecipitation Sequencing; Phenotype; Pilot Projects; Positioning Attribute; Program Evaluation; Proteins; Publications; Research; Research Personnel; Resources; Review Committee; Rheumatology; Sampling; Scanning; Services; Source; System; Systemic Lupus Erythematosus; Techniques; Technology; Tissues; Translational Research; United States; Update; Visit; Woman; Work; Workforce Development; analytical tool; base; biobank; career; cohort; design; diversity and inclusion; innovation; interest; meetings; member; next generation sequencing; novel strategies; operation; professor; programs; prospective; ranpirnase; recruit; sample collection; service delivery; single-cell RNA sequencing; statistical service; success; synergism; tool; transcriptomics; translational scientist; web portal

PROJECT SUMMARY/ABSTRACT - Overall Breaking down barriers to translational research is the key to finding new approaches to inflammatory arthritis and related diseases in adults and children. Four years ago, with P30 support, we built the Joint Biology Consortium (JBC), a shared infrastructure based at the Brigham and Women’s Hospital and Boston Children’s Hospital, to accelerate the work of an arthritis-focused Research Community now spanning 18 research centers across the United States and abroad. Based on the success of the JBC, we propose to continue and expand the fundamental design of three Cores designed around the shared needs of JBC members to enhance the efficiency of existing studies, facilitate innovation, and foster junior investigators. 1. The Administrative Core is the organizational heart of the JBC, coordinating operations and cultivating the scientific potential of the JBC research network, coordinated through the JBC Web Portal. The JBC Synergy Meeting and Visiting Professor program promote scientific interchange, the JBC Workforce Development Group promotes a diverse and inclusive research pipeline, and the JBC Enrichment Program incorporates innovations from award-winning mentors to support JBC Young Investigators via grant aims review, mentoring, and 12 yearly JBC Microgrants of $5,000 to facilitate utilization of JBC services for pilot and feasibility studies. 2. The Human Biosamples Core provides “one-stop shopping” for adult and pediatric biospecimens essential to research in arthritis and related diseases. The HBC leverages 19 distinct sources of samples. The new JBC Recruitment Core provides targeted prospective recruitment from over 100,000 consented individuals based on phenotype and, in many cases, genotype to build a unified pipeline for biospecimens across the lifespan. 3. The Cellular Systems Core provides resource- and expertise-intensive tools for arthritis research. Next- generation sequencing tools include single-cell RNAseq, CITE-seq, ATAC-seq, T-scan, PhIP-seq, and spatial transcriptomics, while protein-based services include CyTOF, tissue mass cytometry, and custom Luminex, all analyzed with assistance and education from the new JBC Bioinformatics Core. Spearheaded by committed investigators and mentors Director PI/PD Dr. Peter Nigrovic and Associate Director and Co-PI Dr. Elizabeth Karlson, the JBC spurs innovation within a deliberately inclusive and highly collaborative network of senior and junior investigators, enabling the Joint Biology Consortium to continue to grow as an engine of translational research in adult and pediatric arthritis and related disease.

项目概要/摘要 - 总体 打破转化研究的障碍是寻找炎症性关节炎新方法的关键 以及成人和儿童的相关疾病。四年前，在 P30 的支持下，我们建立了联合生物学 联盟 (JBC)，一个基于布莱根妇女医院和波士顿儿童医院的共享基础设施 医院，加速以关节炎为重点的研究社区的工作，目前涵盖 18 项研究 中心遍布美国和海外。基于 JBC 的成功，我们建议继续并 围绕 JBC 成员的共同需求扩展三个核心的基本设计 提高现有研究的效率，促进创新并培养初级研究人员。 1. 行政核心是 JBC 的组织核心，负责协调运作并培养 JBC 研究网络的科学潜力，通过 JBC 门户网站进行协调。 JBC 协同效应 会议和客座教授计划促进科学交流和 JBC 劳动力发展 集团提倡多元化和包容性的研究渠道，JBC 丰富计划纳入了 获奖导师的创新通过资助目标审查、指导、 每年 12 次提供 5,000 美元的 JBC 小额赠款，以促进利用 JBC 服务进行试点和可行性研究。 2. 人类生物样本核心为成人和儿童生物样本提供“一站式购物” 关节炎及相关疾病的研究。 HBC 利用 19 个不同的样本来源。新的JBC 招聘核心从超过 100,000 名同意的个人中提供有针对性的前瞻性招聘 对表型和（在许多情况下）基因型进行分析，为整个生命周期的生物样本建立统一的管道。 3. 蜂窝系统核心为关节炎研究提供资源和专业知识密集型工具。下一个- 新一代测序工具包括单细胞 RNAseq、CITE-seq、ATAC-seq、T-scan、PhIP-seq 和 Spatial 转录组学，而基于蛋白质的服务包括 CyTOF、组织质量细胞术和定制 Luminex，所有 在新的 JBC 生物信息学核心的帮助和教育下进行分析。 由忠诚的研究人员和导师带头 PI/PD 总监 Peter Nigrovic 博士及其助理 董事兼联合 PI 伊丽莎白·卡尔森 (Elizabeth Karlson) 博士表示，JBC 在刻意包容和高度 高级和初级研究人员的协作网络，使联合生物学联盟能够继续 成长为成人和儿童关节炎及相关疾病转化研究的引擎。