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Joint Biology Consortium Resource-based Center

联合生物学联盟资源中心

基本信息

批准号：
10454986
负责人：
ELIZABETH W KARLSON
金额：
$ 89.32万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-11 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10454986
关键词：
ATAC-seq Adult Antigens Archives Arthritis Award Bioinformatics Biology Biometry Boston CRISPR screen Cellular Indexing of Transcriptomes and Epitopes by Sequencing Child Childhood Communities Consent Consultations Country Custom Cytometry Data Disease Education Electronic Health Record Ensure Environment Feasibility Studies Fostering Genotype Grant Health Heart Hospitals Human Individual Inflammatory Arthritis Infrastructure Institutes Investments Joints Leadership Link Logistics Longevity Medicine Mentors Methodology Methods Modeling National Institute of Arthritis and Musculoskeletal and Skin Diseases Orthopedics Patients Pediatric Hospitals Phage ImmunoPrecipitation Sequencing Phenotype Pilot Projects Positioning Attribute Program Evaluation Proteins Publications Research Research Personnel Resources Review Committee Rheumatology Sampling Scanning Services Source System Systemic Lupus Erythematosus Techniques Technology Tissues Translational Research United States Update Visit Woman Work Workforce Development analytical tool base biobank career cohort design diversity and inclusion innovation interest meetings member next generation sequencing novel strategies operation professor programs prospective ranpirnase recruit sample collection service delivery single-cell RNA sequencing statistical service success synergism tool transcriptomics translational scientist web portal

项目摘要

PROJECT SUMMARY/ABSTRACT - Overall Breaking down barriers to translational research is the key to finding new approaches to inflammatory arthritis and related diseases in adults and children. Four years ago, with P30 support, we built the Joint Biology Consortium (JBC), a shared infrastructure based at the Brigham and Women’s Hospital and Boston Children’s Hospital, to accelerate the work of an arthritis-focused Research Community now spanning 18 research centers across the United States and abroad. Based on the success of the JBC, we propose to continue and expand the fundamental design of three Cores designed around the shared needs of JBC members to enhance the efficiency of existing studies, facilitate innovation, and foster junior investigators. 1. The Administrative Core is the organizational heart of the JBC, coordinating operations and cultivating the scientific potential of the JBC research network, coordinated through the JBC Web Portal. The JBC Synergy Meeting and Visiting Professor program promote scientific interchange, the JBC Workforce Development Group promotes a diverse and inclusive research pipeline, and the JBC Enrichment Program incorporates innovations from award-winning mentors to support JBC Young Investigators via grant aims review, mentoring, and 12 yearly JBC Microgrants of $5,000 to facilitate utilization of JBC services for pilot and feasibility studies. 2. The Human Biosamples Core provides “one-stop shopping” for adult and pediatric biospecimens essential to research in arthritis and related diseases. The HBC leverages 19 distinct sources of samples. The new JBC Recruitment Core provides targeted prospective recruitment from over 100,000 consented individuals based on phenotype and, in many cases, genotype to build a unified pipeline for biospecimens across the lifespan. 3. The Cellular Systems Core provides resource- and expertise-intensive tools for arthritis research. Next- generation sequencing tools include single-cell RNAseq, CITE-seq, ATAC-seq, T-scan, PhIP-seq, and spatial transcriptomics, while protein-based services include CyTOF, tissue mass cytometry, and custom Luminex, all analyzed with assistance and education from the new JBC Bioinformatics Core. Spearheaded by committed investigators and mentors Director PI/PD Dr. Peter Nigrovic and Associate Director and Co-PI Dr. Elizabeth Karlson, the JBC spurs innovation within a deliberately inclusive and highly collaborative network of senior and junior investigators, enabling the Joint Biology Consortium to continue to grow as an engine of translational research in adult and pediatric arthritis and related disease.

项目摘要/摘要-总体