Vitreo-retinal disease imaging with 3D annular-array ultrasound
使用 3D 环形阵列超声进行玻璃体视网膜疾病成像
基本信息
- 批准号:10289702
- 负责人:
- 金额:$ 35.36万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-22 至 2022-04-06
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAcousticsAdhesionsAgarAgeAge related macular degenerationAgingAlgorithmsAntioxidantsAreaBasic ScienceClassificationClinicalCollaborationsCollagenComputer softwareDataData AnalysesData CollectionDegenerative MyopiaDetectionDevelopmentDevicesDiabetes MellitusDiabetic RetinopathyDiagnosticDiagnostic ProcedureDiseaseDisease ProgressionEarly DiagnosisEarly InterventionEarly treatmentElementsEpidemicEventEyeFamily suidaeGelGenesGoalsGrowthHandHeadHealthHeterogeneityImageIndustrializationInner Limiting MembraneInterventionInvestigationIrisLateralLifeLiquid substanceLow-Level Laser TherapyMeasuresMedicalMethodsModificationMotionMyopiaOpticsPathologyPatientsPharmacologyPhasePosterior Vitreous DetachmentsPosterior eyeball segment structureProcessPropertyResearchResolutionRetinaRetinal DetachmentRiskSaccadesScanningScleraShapesSiteSolidSpatial DistributionStructureSystemTechnologyTractionTranslatingUltrasonographyVisionVisualVitrectomyVitreous HemorrhageVitreous body structureage relatedbasecomputerized data processingcrosslinkcurative treatmentsdesigndisorder of macula of retinaexperiencehuman subjectimaging systemimprovedindexinginfancyquantitative ultrasoundradio frequencytoolvalidation studiesvitreous floater
项目摘要
Project Summary/Abstract
The goal of this translational project is to add quantitative ultrasound (QUS) capabilities to a clinical ophthalmic
ultrasound system in order to characterize vitreous inhomogeneity (i.e., clinically significant vitreous floaters re-
ferred to as Vision Degrading Myodesopsia) as it relates to states of health and disease. Age-related changes
due to collagen cross-linking and aggregation with liquefaction create inhomogeneities that appear non-uniformly
throughout the vitreous body. For patients with myopia these processes occur earlier in life, when vitreo-retinal
adhesion is still strong, and destabilize the vitreous body before adhesion to the retina is weakened, resulting in
a variety of conditions that impact vision. The ability to depict vitreo-retinal organization will offer unique early
stage detection and assessment of vitreo-retinal disease in patients with myopia at risk for retinal detachment
and vitreo-maculopathies resulting from traction..
Currently, no diagnostic method is available to make data-based decisions related to the changes taking place in
the vitreous body before blinding pathologies have developed. The impending epidemic of myopia has created an
urgent clinical need for technologies offering objective and sensitive means for early detection of macromolecular
changes and structural precursors in the vitreous body directly related to vitreo-retinal diseases. A diagnostic
tool capable of quantitatively characterizing the entire vitreous body would assist in developing less invasive and
affordable treatments for early intervention, such as pharmacologic vitreolysis or laser therapy, and for identifying
patients in need of more aggressive interventions with vitrectomy.
In collaboration with Quantel Medical, we will incorporate a new 3D probe and QUS capabilities into a state-of-
the art, 20-MHz annular-array-based clinical ophthalmic ultrasound system. The early stages of the project will
emphasize device enhancements to obtain necessary raw ultrasound data followed by age-normal and myopic
patient data collection and development of QUS algorithms to characterize the vitreous body in 2D. The later
stages of the project will focus on development and integration of a probe capable of volumetric acquisition,
further patient data collection, and QUS classification methods that take advantage of the new volumetric data.
The final system will permit quantitative characterization of the vitreous body and allow for data-based treatment
decisions of vitreo-retinal diseases. While this investigation will focus on myopia, the resultant technology and
approach will have the potential for application in many different clinical settings.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jeffrey Ketterling其他文献
Jeffrey Ketterling的其他文献
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{{ truncateString('Jeffrey Ketterling', 18)}}的其他基金
Vitreo-retinal disease imaging with 3D annular-array ultrasound
使用 3D 环形阵列超声进行玻璃体视网膜疾病成像
- 批准号:
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