High-frequency-ultrasound annular arrays for ophthalmic and small-animal imaging
用于眼科和小动物成像的高频超声环形阵列
基本信息
- 批准号:7640867
- 负责人:
- 金额:$ 34.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-06-15 至 2012-03-31
- 项目状态:已结题
- 来源:
- 关键词:AgeAlgorithmsAmericasAnatomyAnimal ExperimentsAnimalsAnteriorBathingBiometryBlindnessCardiovascular systemCerebral VentriclesClinicalCodeData CollectionData DisplayData SetDetectionDevelopmentDevice or Instrument DevelopmentDevicesDiabetic RetinopathyDiseaseDisease ProgressionElementsEmbryoEngineeringEyeEye BanksFrequenciesGeneticGoalsGrantHumanImageImageryImmersion Investigative TechniqueLateralLegal BlindnessMarketingMedical ResearchMusNoiseOphthalmologyOryctolagus cuniculusPatternPerformancePopulationPositioning AttributePosterior Vitreous DetachmentsReal-Time SystemsResearch PersonnelResolutionRisk FactorsScanningSolutionsSpecimenStructureSystemSystems IntegrationTechniquesTechnologyTestingThree-Dimensional ImagingTimeTissuesTransducersUltrasonographyUniversitiesValidationVisualWorkbasecostdata acquisitiondesigndisease diagnosishuman subjectimage processingimaging Segmentationimprovedin vivoinstrumentinterestmedical schoolsmouse developmentprevent
项目摘要
DESCRIPTION (provided by applicant): The goal of this study is to develop and evaluate advanced annular-array transducer technology for rapid, high-definition imaging in significant medical-research applications. The study will assess high frequency ultrasound (HFU, = 20 MHz) annular arrays in two important applications: 1) imaging microstructure in small animals (e.g., mouse embryos); and 2) imaging posterior vitreous detachments (PVDs) associated with diabetic retinopathy, the leading cause of blindness in the US working-age population according to Prevent Blindness America. Current HFU instruments do not use linear arrays for such applications because of a variety of technical and cost reasons. Instead, current HFU instruments use mechanically scanned, single-element transducers, which provide fine-resolution images over a very limited depth of field (DOF). For small-animal applications, a shallow DOF causes most anatomical boundaries in the specimen to be poorly defined; therefore, accurate micro-structural and volumetric analyses are nearly impossible. For ophthalmic applications, a shallow DOF causes most ocular anatomy to be imaged with poor definition compared to the in-focus region; therefore, because only a small portion of the eye is in focus at a given time, detection and assessment of ocular conditions such as PVD are prone to inaccuracies and false-negative determinations. Annular-array transducers offer a promising approach to significantly extend DOF and to increase the depth range over which fine-lateral resolution is provided. This proposal seeks to continue the HFU annular-array studies initiated under grant EY014371 that demonstrated the improved imaging capability of synthetically-focused annular arrays using in vivo rabbit eyes, in vivo mouse embryos, and human eye-bank eyes. The proposed project will extend those previous studies by developing and validating a real-time HFU, annular-array-based, rapid-imaging system capable of 1) dynamic-receive display imaging at a rate of > 10 fps; 2) data acquisition in < 0.2 s for single-frame, synthetically-focused imaging; and 3) 3D data collection in < 20 s. The proposed system will be modular to facilitate upgrading system components and features. We will validate system performance using animal experiments and human-subject examinations. First, in vivo animal experiments will be conducted with rabbit eyes to evaluate a 40-MHz annular array for anterior-segment imaging and a 20-MHz annular array for posterior segment and full-globe imaging. We also will utilize the 40-MHz annular array to perform in vivo 3D imaging and volumetric segmentation studies with mouse embryos. Second, we will test the hypothesis that 20-MHz annular arrays improve detection of PVD. Validation of this hypothesis will significantly improve our ability to assess disease status in diabetic retinopathy.
描述(由申请人提供):本研究的目标是开发和评估先进的环形阵列换能器技术,用于重要医学研究应用中的快速、高清成像。该研究将在两个重要应用中评估高频超声(HFU,= 20 MHz)环形阵列:1)小动物(例如,小鼠胚胎);和2)对与糖尿病视网膜病变相关的后玻璃体脱离(PVDs)进行成像,根据美国防盲协会(PreventBlindness America),糖尿病视网膜病变是美国工作年龄人口失明的主要原因。由于各种技术和成本原因,目前的HFU仪器不使用线性阵列用于这种应用。相反,当前的HFU仪器使用机械扫描的单元件换能器,其在非常有限的景深(DOF)上提供精细分辨率的图像。对于小动物应用,浅自由度导致标本中的大多数解剖边界定义不清;因此,精确的显微结构和体积分析几乎是不可能的。对于眼科应用,与聚焦区域相比,浅自由度导致大多数眼部解剖结构的成像清晰度较差;因此,由于在给定时间只有一小部分眼睛处于焦点内,因此对诸如PVD等眼部状况的检测和评估容易出现不准确和假阴性确定。环形阵列换能器提供了一种有前途的方法,以显着扩展自由度,并增加深度范围内提供精细的横向分辨率。该提案旨在继续在EY 014371资助下启动的HFU环形阵列研究,该研究证明了使用体内兔眼、体内小鼠胚胎和人眼库眼的合成聚焦环形阵列的成像能力得到改善。拟议项目将通过开发和验证实时HFU、基于环形阵列的快速成像系统来扩展先前的研究,该系统能够:1)以> 10 fps的速率进行动态接收显示成像; 2)在< 0.2 s内进行单帧合成聚焦成像的数据采集; 3)在< 20 s内进行3D数据采集。拟议的系统将采用模块化设计,以方便系统组件和功能的升级。我们将使用动物实验和人体受试者检查来验证系统性能。首先,将使用兔眼进行体内动物实验,以评价用于前段成像的40 MHz环形阵列和用于后段和全眼球成像的20 MHz环形阵列。我们还将利用40 MHz环形阵列对小鼠胚胎进行体内3D成像和体积分割研究。其次,我们将测试的假设,20 MHz的环形阵列提高检测PVD。验证这一假设将显著提高我们评估糖尿病视网膜病变疾病状态的能力。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jeffrey Ketterling其他文献
Jeffrey Ketterling的其他文献
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{{ truncateString('Jeffrey Ketterling', 18)}}的其他基金
Vitreo-retinal disease imaging with 3D annular-array ultrasound
使用 3D 环形阵列超声进行玻璃体视网膜疾病成像
- 批准号:
10664131 - 财政年份:2022
- 资助金额:
$ 34.48万 - 项目类别:
Vitreo-retinal disease imaging with 3D annular-array ultrasound
使用 3D 环形阵列超声进行玻璃体视网膜疾病成像
- 批准号:
10289702 - 财政年份:2021
- 资助金额:
$ 34.48万 - 项目类别:
Fine-resolution mapping of micro vasculature after placental transport of acoustic nanodrops
声学纳米滴胎盘运输后微脉管系统的精细分辨率绘图
- 批准号:
9983114 - 财政年份:2019
- 资助金额:
$ 34.48万 - 项目类别:
In utero mouse embryo phenotyping with high-frequency ultrasound
高频超声对小鼠子宫内胚胎表型分析
- 批准号:
9357583 - 财政年份:2016
- 资助金额:
$ 34.48万 - 项目类别:
In utero mouse embryo phenotyping with high-frequency ultrasound
高频超声对小鼠子宫内胚胎表型分析
- 批准号:
9168204 - 财政年份:2016
- 资助金额:
$ 34.48万 - 项目类别:
Quantitative characterization of vitreous degeneration in myopia
近视玻璃体变性的定量表征
- 批准号:
8823987 - 财政年份:2015
- 资助金额:
$ 34.48万 - 项目类别:
Advanced acoustic field measurements of shock wave lithotripters
冲击波碎石机的先进声场测量
- 批准号:
7760534 - 财政年份:2009
- 资助金额:
$ 34.48万 - 项目类别:
Advanced acoustic field measurements of shock wave lithotripters
冲击波碎石机的先进声场测量
- 批准号:
7588478 - 财政年份:2009
- 资助金额:
$ 34.48万 - 项目类别:
Acoustic Contrast Agents for Use with High-frequency Ultrasound
用于高频超声的声学造影剂
- 批准号:
7917415 - 财政年份:2008
- 资助金额:
$ 34.48万 - 项目类别:
Acoustic Contrast Agents for Use with High-frequency Ultrasound
用于高频超声的声学造影剂
- 批准号:
8135333 - 财政年份:2008
- 资助金额:
$ 34.48万 - 项目类别:
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