Quantitative characterization of vitreous degeneration in myopia

近视玻璃体变性的定量表征

基本信息

  • 批准号:
    8823987
  • 负责人:
  • 金额:
    $ 23.41万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-01-01 至 2016-12-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The ultimate goal of this project is to develop a quantitative, ultrasound-based assessment of the vitreous as it relates to vitreo-retinal diseases, such as myopia and diabetic retinopathy, at an early stage before severe outcomes (e.g., blindness) occur. Normal age-related changes (e.g., collagen cross-linking and aggregation, liquefaction, cellular debris, etc.) create inhomogeneities, such as floaters, to appear throughout the vitreous in a non-uniform distribution; these inhomogeneities can serve as weak acoustic scatterers. Concurrent changes at the vitreo-retinal interface weaken the adhesion of the posterior vitreous cortex to the internal limiting lamina of the retina, resulting in posterior viteous detachment. For patients with myopia, these normal processes do not typically occur in tandem because liquefaction is accelerated and the vitreous destabilizes before the vitreous adhesion to the retina is weakened. No diagnostic method is now available to characterize the changes taking place throughout the vitreous volume at an early stage before irreversible pathologies have developed or to determine how these changes relate to progression of diseases. Thus, a clinical need exists to detect within the vitreous the macromolecular changes and structural precursors related to vitreo-retinal disease. We will assemble a novel, high-resolution, annular-array ultrasound system capable of acquiring image data of the entire vitreous and then use quantitative ultrasound methods to characterize vitreous inhomogeneities based on parameters derived from raw ultrasound backscatter signals. The system will utilize state-of-the-art, 20-MHz, annular-array technology to achieve an unprecedented improvement in depth-of-field, resolution and sensitivity relative to current clinical ultrasound technology. The proposed technology will overcome limitations of optical coherence tomography, such as its restricted lateral view through the pupil (due to opaque intervening structures such as the iris, sclera, and possibly cataracts) and its inability to image optically transparent tissue. The early stages of th project will emphasize assembling a hand-held clinical prototype annular-array system and developing signal-processing methods. Later stages will focus on human-subject imaging and quantification of vitreous inhomogeneities occurring during normal aging and myopia.
描述(由申请人提供):本项目的最终目标是开发一种定量的、基于超声的玻璃体评估方法,因为它与玻璃体视网膜疾病有关, 例如近视和糖尿病视网膜病变,在严重后果之前的早期阶段(例如,失明)发生。正常的年龄相关变化(例如,胶原交联和聚集、液化、细胞碎片等)产生不均匀性,如飞蚊症,出现在整个 玻璃质呈不均匀分布;这些不均匀性可用作弱的声散射体。玻璃体-视网膜界面的并发变化削弱了后玻璃体皮质与视网膜内界层的粘附,导致后玻璃体脱离。对于近视患者,这些正常过程通常不会同时发生,因为液化加速,并且在玻璃体与视网膜的粘附减弱之前玻璃体不稳定。现在没有诊断方法可用于表征在不可逆病理发生之前的早期阶段整个玻璃体积发生的变化,或确定这些变化与疾病进展的关系。因此,临床上需要检测玻璃体内与玻璃体视网膜疾病相关的大分子变化和结构前体。我们将组装一个新的,高分辨率,环形阵列超声系统能够采集整个玻璃体的图像数据,然后使用定量超声方法来表征玻璃体的不均匀性的基础上,从原始超声背向散射信号的参数。该系统将利用最先进的20 MHz环形阵列技术,相对于当前的临床超声技术,在景深、分辨率和灵敏度方面实现前所未有的改进。所提出的技术将克服光学相干断层扫描的局限性,例如其通过瞳孔的受限侧视图(由于不透明的介入结构,例如虹膜、巩膜和可能的白内障)以及其无法对光学透明组织进行成像。该项目的早期阶段将强调组装一个手持临床原型环形阵列系统和开发信号处理方法。后期阶段将集中在人类受试者成像和量化的玻璃体不均匀性发生在正常老化和近视。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Jeffrey Ketterling其他文献

Jeffrey Ketterling的其他文献

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{{ truncateString('Jeffrey Ketterling', 18)}}的其他基金

Vitreo-retinal disease imaging with 3D annular-array ultrasound
使用 3D 环形阵列超声进行玻璃体视网膜疾病成像
  • 批准号:
    10664131
  • 财政年份:
    2022
  • 资助金额:
    $ 23.41万
  • 项目类别:
Vitreo-retinal disease imaging with 3D annular-array ultrasound
使用 3D 环形阵列超声进行玻璃体视网膜疾病成像
  • 批准号:
    10289702
  • 财政年份:
    2021
  • 资助金额:
    $ 23.41万
  • 项目类别:
Fine-resolution mapping of micro vasculature after placental transport of acoustic nanodrops
声学纳米滴胎盘运输后微脉管系统的精细分辨率绘图
  • 批准号:
    9983114
  • 财政年份:
    2019
  • 资助金额:
    $ 23.41万
  • 项目类别:
In utero mouse embryo phenotyping with high-frequency ultrasound
高频超声对小鼠子宫内胚胎表型分析
  • 批准号:
    9357583
  • 财政年份:
    2016
  • 资助金额:
    $ 23.41万
  • 项目类别:
In utero mouse embryo phenotyping with high-frequency ultrasound
高频超声对小鼠子宫内胚胎表型分析
  • 批准号:
    9168204
  • 财政年份:
    2016
  • 资助金额:
    $ 23.41万
  • 项目类别:
Advanced acoustic field measurements of shock wave lithotripters
冲击波碎石机的先进声场测量
  • 批准号:
    7760534
  • 财政年份:
    2009
  • 资助金额:
    $ 23.41万
  • 项目类别:
Advanced acoustic field measurements of shock wave lithotripters
冲击波碎石机的先进声场测量
  • 批准号:
    7588478
  • 财政年份:
    2009
  • 资助金额:
    $ 23.41万
  • 项目类别:
High-frequency-ultrasound annular arrays for ophthalmic and small-animal imaging
用于眼科和小动物成像的高频超声环形阵列
  • 批准号:
    7640867
  • 财政年份:
    2008
  • 资助金额:
    $ 23.41万
  • 项目类别:
Acoustic Contrast Agents for Use with High-frequency Ultrasound
用于高频超声的声学造影剂
  • 批准号:
    7917415
  • 财政年份:
    2008
  • 资助金额:
    $ 23.41万
  • 项目类别:
Acoustic Contrast Agents for Use with High-frequency Ultrasound
用于高频超声的声学造影剂
  • 批准号:
    8135333
  • 财政年份:
    2008
  • 资助金额:
    $ 23.41万
  • 项目类别:

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