Biostatistics and Informatics Core

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BIOSTATISTICS AND BIOINFORMATICS CORE: PROJECT SUMMARY The overall objective of the TRACER Biostatistics and Bioinformatics Core (BBC) is to serve as the focal point from which the TRACER investigators and career development candidates can draw the much needed biostatistical, genomics, and biomedical informatics expertise needed for proper planning and execution of their research projects. These services include assisting in experimental design, study plan development, hypotheses refinement, database integration and access, data quality control, sample size requirements and power calculations, analysis of the statistical design, development of randomization and stratification procedures, interim analyses, analysis of completed results (which includes both biostatistical and genomics analyses), presentation of research findings, and scientific publication to disseminate new findings in the prevention and treatment of lung cancer. The BBC resource will be directed by Dr. Bandyopadhyay from VCU, with core personnel included across the three TRACER sites. To materialize the TRACER objectives, the BBC has proposed 3 specific aims, which broadly encompasses providing biostatistical and genomics analytics expertise (Aim 1), providing efficient data management, integration and distribution (Aim 2), and provide the much needed biostatistical training to TRACER investigators and community partners, as well as exploring novel advancements in biostatistical methodology in lung cancer (Aim 3). To achieve this, BBC personnel, in addition to their own research interactions with the TRACER members, can also call on additional assistance from various other biostatisticians, bioinformaticians, genomics experts, and senior statistical analysts with significant cancer expertise, all integrated within the respective Biostatistics Shared Resources at the NCI-designated cancer centers at VCU, MUSC, and CoH. The BBC thus constitute a tightly integrated component of the TRACER, and the services provided will add significant value to the realization of TRACER goals, which would not have been achieved through alternative vendors.