Biostatistics and Informatics Core

生物统计学和信息学核心

• 批准号: 10493306
• 负责人: Dipankar Bandyopadhyay
• 金额: $ 12.03万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10493306
• 关键词: Address; Behavioral; Bioinformatics; Biometry; Biostatistics Shared Resource; Cancer Center; Cancer Research Project; Center for Translational Science Activities; City of Hope Comprehensive Cancer Center; Clinical; Communities; Computational algorithm; Computerized Medical Record; Control Groups; DNA sequencing; Data; Databases; Development; Development Plans; Doctor of Philosophy; Educational Activities; Ensure; Epidemiology; Experimental Designs; Genomics; Goals; Human Resources; Individual; Informatics; Institution; Intervention; Knowledge; Location; Logistics; Malignant Neoplasms; Malignant neoplasm of lung; Manuscripts; Medical; Mentors; Methodology; Molecular; NCI-Designated Cancer Center; Outcome; Outcome Study; Pathology; Population; Prevention; Principal Investigator; Procedures; Proteomics; Protocols documentation; Publications; Quality Control; Randomized; Reporting; Reproducibility; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Research Support; Resources; Sample Size; Scheme; Secure; Services; Site; South Carolina; Statistical Data Interpretation; Stratification; Testing; The Cancer Genome Atlas; Time; Training; Translating; Translational Research; Universities; Update; Validation; Vendor; Virginia; analytical tool; biomedical informatics; cBioPortal; cancer health disparity; career development; central database; cohort; community engagement; comparison group; data integration; data management; data quality; design; experimental study; firewall; flexibility; genomic data; high dimensionality; innovation; interest; mathematical model; member; novel; research study; social determinants; sociodemographics; success; transcriptome sequencing; web interface

BIOSTATISTICS AND BIOINFORMATICS CORE: PROJECT SUMMARY The overall objective of the TRACER Biostatistics and Bioinformatics Core (BBC) is to serve as the focal point from which the TRACER investigators and career development candidates can draw the much needed biostatistical, genomics, and biomedical informatics expertise needed for proper planning and execution of their research projects. These services include assisting in experimental design, study plan development, hypotheses refinement, database integration and access, data quality control, sample size requirements and power calculations, analysis of the statistical design, development of randomization and stratification procedures, interim analyses, analysis of completed results (which includes both biostatistical and genomics analyses), presentation of research findings, and scientific publication to disseminate new findings in the prevention and treatment of lung cancer. The BBC resource will be directed by Dr. Bandyopadhyay from VCU, with core personnel included across the three TRACER sites. To materialize the TRACER objectives, the BBC has proposed 3 specific aims, which broadly encompasses providing biostatistical and genomics analytics expertise (Aim 1), providing efficient data management, integration and distribution (Aim 2), and provide the much needed biostatistical training to TRACER investigators and community partners, as well as exploring novel advancements in biostatistical methodology in lung cancer (Aim 3). To achieve this, BBC personnel, in addition to their own research interactions with the TRACER members, can also call on additional assistance from various other biostatisticians, bioinformaticians, genomics experts, and senior statistical analysts with significant cancer expertise, all integrated within the respective Biostatistics Shared Resources at the NCI-designated cancer centers at VCU, MUSC, and CoH. The BBC thus constitute a tightly integrated component of the TRACER, and the services provided will add significant value to the realization of TRACER goals, which would not have been achieved through alternative vendors.

生物统计学和生物信息学核心：项目摘要 TRACER生物统计学和生物信息学核心（BBC）的总体目标是作为 TRACER调查人员和职业发展候选人可以从中提取急需的 生物统计学，基因组学和生物医学信息学专业知识需要适当的规划和执行， 研究项目。这些服务包括协助实验设计，研究计划制定，假设 细化、数据库集成和访问、数据质量控制、样本量要求和功效 计算、统计设计分析、随机化和分层程序开发， 中期分析、已完成结果分析（包括生物统计学和基因组学分析）， 介绍研究结果，并出版科学出版物，传播预防和 肺癌的治疗BBC资源将由VCU的Bandyopadhyay博士指导， 包括三个TRACER研究中心的人员。为了实现追踪者的目标，BBC已经 提出了3个具体目标，其中广泛包括提供生物统计和基因组学分析专业知识 (Aim 1）提供高效的数据管理、集成和分发（目标2），并提供急需的 对TRACER研究人员和社区合作伙伴进行生物统计培训，以及探索新的 肺癌生物统计学方法的进展（目标3）。为了实现这一目标，BBC的工作人员，此外， 他们自己的研究与TRACER成员的互动，也可以呼吁从各种额外的援助， 其他生物统计学家、生物信息学家、基因组学专家和患有重大癌症的高级统计分析师 专业知识，所有这些都集成在NCI指定癌症的相应生物统计学共享资源中 在VCU，MUSC和CoH的中心。因此，英国广播公司构成了TRACER的一个紧密结合的组成部分， 所提供的服务将为实现TRACER目标增加重要价值，而这些目标本来是不可能实现的。 通过替代供应商实现。