Investigating the Role of Gr23 Gene in the Mating Capacity of Malaria Vector Mosquito Anopheles coluzzii
Gr23基因在疟疾媒介蚊子按蚊交配能力中的作用研究
基本信息
- 批准号:10288802
- 负责人:
- 金额:$ 7.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-06-09 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptedAedesAfferent NeuronsAllelesAnimalsAnopheles GenusArthropodsBehaviorBloodBreedingCandidate Disease GeneCarbon DioxideCessation of lifeChemicalsCodeComplexCuesCulicidaeDefectDengueDetectionDipteraEnvironmentExhibitsFailureFemaleFilarial ElephantiasesGene TargetingGenesHumanHydrocarbonsIn VitroJapanese EncephalitisLegMalariaMaxillaMediatingMembraneMolecularMolecular TargetMosquito ControlNeuronsOdorant ReceptorsOdorsParasitesPartner in relationshipPatternPheromonePlasmodium falciparumPlayProcessPublic HealthReproductionResearch ProposalsRoleSemiochemicalsSystemTestingTriad Acrylic ResinWest Nile EncephalitisWorkXenopus oocyteYellow FeverZika Virusappendagebasecarbon dioxide receptorfeedingin vivolabiamalemating behaviormutantnovelolfactory sensory neuronspathogenreceptorreproductiveresponsetranscriptomicsvectorvector mosquito
项目摘要
Project Summary
As one of the most important vectors for the malaria parasite Plasmodium falciparum, which infected
approximately 228 million people worldwide in 2018 and accounted for more than 400,000 deaths (WHO,
2019), the An. coluzzii mosquito has long been a formidable concern to public health. These mosquitoes rely
heavily on their chemosensory system to detect chemical cues involved in the mating process, including
aggregation pheromones and cuticular hydrocarbons. Swarm aggregation pheromones increase the possibility
of encountering female mosquitoes while cuticular hydrocarbons help male mosquitoes recognize conspecific
females. A recent finding of ours indicated that not only were Gr23-null mutants insensitive to carbon dioxide
stimulation, they also appeared to have some mating defect, as they failed to self-breed. Previous
transcriptomic studies in Aedes mosquitoes indicated that Gr23 is expressed in CO2-sensitive neurons in the
maxillary palps, but presents the highest expression among all gustatory receptors in the antennae and other
chemosensory appendages, which suggests additional roles of Gr23 in chemosensation beyond CO2
reception. Therefore, the aim of this research proposal is to determine the role of Gr23 in the mating capacity
of An. coluzzii. Here, we hypothesize that the observed self-breeding defect of Gr23 mutants is due to their
inability to detect mating-related chemical cues, and that the Gr23 receptor plays a critical role in this
chemosensory process. Accordingly, the fundamental questions I propose to address are: (1) what is the
expression pattern of Gr23 in the chemosensory neurons of the mating-related appendages in An. coluzzii? (2)
What is the molecular function of Gr23 in detecting the mating-related semiochemicals? In addressing these
questions, this work will further our understanding of the role of Gr23 in the mosquito's odor-mediated mating
process, which would have great potential as a novel molecular target in mosquito control.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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LAURENCE J ZWIEBEL其他文献
LAURENCE J ZWIEBEL的其他文献
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{{ truncateString('LAURENCE J ZWIEBEL', 18)}}的其他基金
Characterization of Ionotropic Receptors in Mating and Blood Feeding in Anopheles mosquitoes
按蚊交配和吸血中离子型受体的表征
- 批准号:
10736638 - 财政年份:2023
- 资助金额:
$ 7.92万 - 项目类别:
Investigating the Role of Gr23 Gene in the Mating Capacity of Malaria Vector Mosquito Anopheles coluzzii
Gr23基因在疟疾媒介蚊子按蚊交配能力中的作用研究
- 批准号:
10425425 - 财政年份:2021
- 资助金额:
$ 7.92万 - 项目类别:
Molecular Neurogenetics of Olfactory Driven Aggression and Social Hierarchy in a Model Insect System
模型昆虫系统中嗅觉驱动的攻击性和社会等级的分子神经遗传学
- 批准号:
9765351 - 财政年份:2018
- 资助金额:
$ 7.92万 - 项目类别:
Molecular Neurogenetics of Olfactory Driven Aggression and Social Hierarchy in a Model Insect System
模型昆虫系统中嗅觉驱动的攻击性和社会等级的分子神经遗传学
- 批准号:
9926283 - 财政年份:2018
- 资助金额:
$ 7.92万 - 项目类别:
Molecular Neurogenetics of Olfactory Driven Aggression and Social Hierarchy in a Model Insect System
模型昆虫系统中嗅觉驱动的攻击性和社会等级的分子神经遗传学
- 批准号:
10170383 - 财政年份:2018
- 资助金额:
$ 7.92万 - 项目类别:
Molecular Characterization of an Anopheline Ammonium Transporter
按蚊铵转运蛋白的分子表征
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9278096 - 财政年份:2016
- 资助金额:
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8227919 - 财政年份:2012
- 资助金额:
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Targeted gene inactivation in Anopeles gambiae via artificial nucleases
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