Wake forest Clinical and Translational Science Award

联系PD/PI：Li、King C。 项目总结/摘要 阻碍公共卫生进步的一个关键问题是， 健康和在日常实践中实施的措施。此外，要想影响力最大， 参与者应参与所有类型的临床和转化研究，以确保 研究成果向公众传播的可能性，以及传播这些成果以改善 公共卫生有意义。最后，研究成果的实施需要翻译 研究是在一个有效率和有组织的环境中进行的。所有这些活动都对学习健康至关重要 护理系统，为信息反馈回路、基于团队的学习和调查提供基础， 利益相关者参与、教育机会、持续改进和可持续性。使命 维克森林转化科学研究所（TSI）的目标是提供一个创新的，高效的，可持续的 研究基础设施，以加速WF的转型，从而加快发现的转化， 增进健康。临床和转化科学奖（CTSA）申请的目的是 协同TSI已经在维克森林浸信会带来的根本性积极变化 健康TSI在发展和扩充翻译人才队伍方面已经取得了实质性进展; 在生物统计学，流行病学和研究设计方面提供出色的支持;并确保我们的研究 遵守监管准则并符合道德标准。我们快速增长的临床集成 Network将汇总来自我们附属机构的数据，以提供非常丰富的临床信息来源， 通过我们的生物医学信息学专业知识，为新的研究方向提供信息。我们可以向反恐安全局提供 网络我们的资源和专业知识，建立有效的临床研究支持计划和广泛的 具有开展多中心临床研究的经验，尤其是针对老年人的研究，其中 我们的往绩堪称典范。TSI还在社区参与，团队科学， 招募特殊人群进行转化研究。我们提出了新的实验方法 这将测试方法论，以推进转化科学的科学。特别是，我们可以提供 世界一流的能力，以支持使用非人类灵长类动物模型进行高转化价值的研究 公共卫生。在CTSA的支持下，我们可以利用这一全面的基础设施为新的试点项目提供资金 和新的多学科研究团队，并提供创新的培训，以帮助这些企业取得成功。醒 Forest Baptist Health是一个完全集成的医疗中心，其中治理，质量改进和 研究发现--包括可能由这些发现产生的知识产权--高度 对齐。总之，TSI准备成为CTSA网络中的生产中心。 项目摘要/摘要第203页 联系PD/PI：Li、King C。

Contact PD/PI: Li, King C. Project Summary/Abstract A critical issue that impedes advances in public health is the chasm between what we know can improve health and what is implemented in everyday practice. In addition, to have the highest impact, diverse participants should be involved in all types of clinical and translational research, to ensure both the relevance of research findings to the general population and the likelihood that they can be disseminated to improve public health in a meaningful way. Finally, implementation of research findings requires that translational research occurs in an efficient and organized environment. All of these activities are critical to a learning health care system by providing the foundation for information feedback loops, team-based learning and investigation, stakeholder participation, opportunities for education, continuous improvement, and sustainability. The mission of the Wake Forest Translational Science Institute (TSI) is to provide an innovative, efficient, and sustainable research infrastructure to accelerate WF's transformation, and thus speed the translation of discoveries to improve health. The purpose of this Clinical and Translational Science Award (CTSA) application is to synergize the fundamental positive changes that the TSI has already brought to bear at Wake Forest Baptist Health. The TSI has already made substantive progress to develop and augment our translational workforce; provide outstanding support in biostatistics, epidemiology, and research design; and assure that our research complies with regulatory guidelines and meets ethical standards. Our rapidly growing Clinically Integrated Network will aggregate data from our affiliates to provide an extraordinarily rich source of clinical information to inform new research directions, facilitated by our biomedical informatics expertise. We can offer to the CTSA network our resources and expertise in building efficient clinical research support programs and extensive experience in the conduct of multi-center clinical research, especially studies focused on older adults, in which our track record is exemplary. The TSI also has model programs in community engagement, team science, and recruitment of special populations into translational research. We propose novel experimental approaches that will test methodologies to advance the science of translational science. In particular, we can offer our world-class capabilities to support the use of nonhuman primate models for research of high translational value to public health. With CTSA support, we can use this comprehensive infrastructure to fund new pilot projects and new multidisciplinary research teams, and offer innovative training to help those ventures succeed. Wake Forest Baptist Health is a fully integrated medical center in which governance, quality improvement, and research discoveries – including the intellectual property that may result from those discoveries – are highly aligned. In summary, the TSI is poised to be a productive hub within the CTSA network. Project Summary/Abstract Page 203 Contact PD/PI: Li, King C.