False Memories in Alzheimer's Disease

阿尔茨海默病的错误记忆

• 批准号: 10292883
• 负责人: Andrew Budson
• 金额: --
• 依托单位: VA BOSTON HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10292883
• 关键词: Activities of Daily Living; Alzheimer' s Disease; Behavioral; Brain; Clinical; Cognitive; Communities; Data; Dementia; Event-Related Potentials; Family; Goals; Grant; Laboratories; Life; Memory; Methods; Modeling; Neuropsychological Tests; Patients; Physiological; Physiology; Quality of life; Questionnaires; Research; Techniques; Testing; Translating; Veterans; Work; base; cognitive function; experimental study; forgetting; improved; mild cognitive impairment; novel; therapy design

Many Veterans with Alzheimer’s disease in the mild cognitive impairment and mild dementia stages live alone in the community. Although it has been known for over 100 years that forgetting interferes with their quality of life, we have obtained new data demonstrating that rates of false memories in those with AD are extremely high—almost as high as forgetting. The goal of this grant is to understand the physiological and cognitive basis of false memories and their clinical and functional implications in daily life. We need to understand to what degree false memories impact the daily life of patients with AD. We need to determine good models of false memories in the laboratory that correlate with false memories in the real world. We need to use those models to understand the cognitive and physiological bases of false memories, and to try out different strategies, aids, and techniques to reduce false memories. To accomplish these goals we plan to do the following studies. Experiment 1 will examine the correlation between false memories and forgetting (using standard and novel questionnaires) with activities of daily living and quality of life (using standard questionnaires) in patients with AD. Experiment 2 will examine the correlation between false memories in daily life (using a novel questionnaire) and several experimental false memory paradigms in patients with AD. Experiment 3 will use standard neuropsychological tests to examine the cognitive domains that underlie false memories in patients with AD. Experiment 4 will use novel behavioral experimental memory paradigms to examine the memory components that underlie false memories in patients with AD. Experiment 5 will use a novel event-related potential (ERP) false memory paradigm to examine the physiological basis of false memories in patients with AD. Once these goals have been accomplished, we will be ready to apply these methods to reduce false memories in the daily life of Veterans with AD. Our prior VA Merit research worked to better understand true and false memories of patients with AD in the laboratory. The present proposal builds on the prior work and takes a major step forward, aiming to understand how false memories in daily life relate to false memories in the laboratory, as well as to cognitive function, brain physiology, and—most importantly—quality of life. Once these relationships are understood, laboratory models of false memories can be utilized to rationally design interventions that can reduce false memories in the daily life patients with AD, improving quality of life for patients and their families.

许多患有阿尔茨海默病的退伍军人患有轻度认知障碍和轻度痴呆 阶段独自生活在社区中。尽管 100 多年来人们都知道忘记 干扰他们的生活质量，我们获得的新数据表明，错误率 AD 患者的记忆力非常强，几乎与遗忘一样高。本次赠款的目标 是了解错误记忆的生理和认知基础及其临床和 日常生活中的功能意义。我们需要了解错误记忆的影响程度 AD患者的日常生活。我们需要在错误记忆中确定良好的模型 与现实世界中的错误记忆相关的实验室。我们需要使用这些模型 了解错误记忆的认知和生理基础，并尝试不同的方法 减少错误记忆的策略、辅助工具和技术。 为了实现这些目标，我们计划进行以下研究。实验 1 将检查 错误记忆和遗忘之间的相关性（使用标准和新颖的问卷） AD 患者的日常生活活动和生活质量（使用标准问卷）。 实验2将检查日常生活中错误记忆之间的相关性（使用小说 问卷）和 AD 患者的一些实验性错误记忆范式。实验 3 将使用标准的神经心理学测试来检查错误背后的认知领域 AD患者的记忆。实验4将使用新颖的行为实验记忆 研究 AD 患者错误记忆背后的记忆成分的范例。 实验 5 将使用一种新颖的事件相关电位 (ERP) 错误记忆范式来检查 AD 患者错误记忆的生理基础。一旦这些目标实现 完成后，我们将准备好应用这些方法来减少日常生活中的错误记忆 患有 AD 的退伍军人。 我们之前的 VA Merit 研究致力于更好地理解真实和错误的记忆 实验室里患有 AD 的患者。本提案建立在先前工作的基础上，并采取了重大举措 向前迈进一步，旨在了解日常生活中的错误记忆与现实生活中的错误记忆有何关系 实验室，以及认知功能、大脑生理学，以及最重要的生活质量。 一旦理解了这些关系，错误记忆的实验室模型就可以用来 合理设计干预措施，减少AD患者日常生活中的错误记忆， 提高患者及其家人的生活质量。