False Memories in Alzheimer's Disease

阿尔茨海默病的错误记忆

• 批准号: 10292883
• 负责人: Andrew Budson
• 金额: --
• 依托单位: VA BOSTON HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10292883
• 关键词: Activities of Daily Living; Alzheimer' s Disease; Behavioral; Brain; Clinical; Cognitive; Communities; Data; Dementia; Event-Related Potentials; Family; Goals; Grant; Laboratories; Life; Memory; Methods; Modeling; Neuropsychological Tests; Patients; Physiological; Physiology; Quality of life; Questionnaires; Research; Techniques; Testing; Translating; Veterans; Work; base; cognitive function; experimental study; forgetting; improved; mild cognitive impairment; novel; therapy design

Many Veterans with Alzheimer’s disease in the mild cognitive impairment and mild dementia stages live alone in the community. Although it has been known for over 100 years that forgetting interferes with their quality of life, we have obtained new data demonstrating that rates of false memories in those with AD are extremely high—almost as high as forgetting. The goal of this grant is to understand the physiological and cognitive basis of false memories and their clinical and functional implications in daily life. We need to understand to what degree false memories impact the daily life of patients with AD. We need to determine good models of false memories in the laboratory that correlate with false memories in the real world. We need to use those models to understand the cognitive and physiological bases of false memories, and to try out different strategies, aids, and techniques to reduce false memories. To accomplish these goals we plan to do the following studies. Experiment 1 will examine the correlation between false memories and forgetting (using standard and novel questionnaires) with activities of daily living and quality of life (using standard questionnaires) in patients with AD. Experiment 2 will examine the correlation between false memories in daily life (using a novel questionnaire) and several experimental false memory paradigms in patients with AD. Experiment 3 will use standard neuropsychological tests to examine the cognitive domains that underlie false memories in patients with AD. Experiment 4 will use novel behavioral experimental memory paradigms to examine the memory components that underlie false memories in patients with AD. Experiment 5 will use a novel event-related potential (ERP) false memory paradigm to examine the physiological basis of false memories in patients with AD. Once these goals have been accomplished, we will be ready to apply these methods to reduce false memories in the daily life of Veterans with AD. Our prior VA Merit research worked to better understand true and false memories of patients with AD in the laboratory. The present proposal builds on the prior work and takes a major step forward, aiming to understand how false memories in daily life relate to false memories in the laboratory, as well as to cognitive function, brain physiology, and—most importantly—quality of life. Once these relationships are understood, laboratory models of false memories can be utilized to rationally design interventions that can reduce false memories in the daily life patients with AD, improving quality of life for patients and their families.

许多患有阿尔茨海默氏病的退伍军人在轻度认知障碍和轻度痴呆症中 舞台独自生活在社区中。尽管已有100多年的历史了 干扰了他们的生活质量，我们获得了新数据，表明了错误的速度 广告患者中的回忆非常高 - 几乎与忘记一样高。这笔赠款的目标 是要了解虚假记忆的身体和认知基础及其临床和 日常生活的功能含义。我们需要了解虚假记忆在多大程度上影响 AD患者的日常生活。我们需要确定良好的虚假记忆模型 与现实世界中虚假记忆相关的实验室。我们需要使用这些模型来 了解虚假记忆的认知和身体基础，并尝试不同 减少虚假记忆的策略，艾滋病和技术。 为了实现这些目标，我们计划进行以下研究。实验1将检查 虚假记忆与忘记之间的相关性（使用标准和新颖的问卷） 随着AD患者的日常生活和生活质量（使用标准问卷）的活动。 实验2将检查日常生活中虚假记忆之间的相关性（使用小说 AD患者的问卷）和几个实验性假记忆范例。实验 3将使用标准的神经心理学测试来检查基于错误的认知领域 AD患者的记忆。实验4将使用新颖的行为实验记忆 检查AD患者中错误记忆的记忆成分的范例。 实验5将使用新颖的事件相关电位（ERP）假记忆范式检查 AD患者虚假记忆的物理基础。一旦这些目标 完成了，我们将准备采用这些方法来减少在日常生活中的虚假记忆 充满广告的退伍军人。 我们先前的VA优点研究旨在更好地理解对的真实和错误的记忆 实验室中有AD的患者。目前的提议基于先前的工作，并进行了大专业 向前迈进，旨在了解日常生活中的虚假记忆如何与虚假记忆有关 实验室以及认知功能，脑生理以及最重要的是生活的质量。 一旦理解了这些关系，可以将虚假记忆的实验室模型用于 理性设计干预措施，可以减少AD日常生活患者的虚假记忆， 改善患者及其家人的生活质量。