Cannabis use, PrEP and HIV transmission risk Among Black MSM in Chicago

项目摘要 黑人同性恋、双性恋和其他男男性行为者（MSM）面临着不成比例的艾滋病毒负担。 在受艾滋病毒严重影响的人群中，如黑人男男性行为者， 降低新的艾滋病毒感染率;然而，它在高危人群中的吸收，特别是黑人男男性行为者， 被限制。因此，我们建议在一个黑人MSM队列中进行急需的PrEP研究， 包括相关行为的影响，特别是大麻的使用，这在黑人中非常普遍。 男男性接触者关于大麻使用对PrEP的影响的研究取得了相互矛盾的结果，而且还没有被证实。 在黑人男男性接触者中进行了严格研究。因此，拟议的R 01研究将评估横断面和 大麻使用和PrEP结果之间的纵向关联（例如，使用、坚持）和艾滋病毒 使用事件水平和客观生物标志物的传播风险（例如生物炎症、性风险行为） 艾滋病毒阴性黑人SMM中的数据。为了实现这些具体目标，我们将开展网络和 邻里（N2）大麻PrEP研究在芝加哥，IL.我们将跟踪250名艾滋病毒阴性参与者， 最初的N2队列再延长1年，共3个研究波。我们将用创新和严谨的 方法，以收集额外的数据，如生态瞬时评估方法和目标 在每一波的14天期间，测量大麻使用，PrEP使用和免疫功能。潜在 调查结果可以影响干预措施的制定和实施，并为政策提供信息，以增加PrEP 接受和坚持，解决物质使用问题，减少艾滋病毒传播率和差距。

PROJECT SUMMARY Black gay, bisexual and other men who have sex with men (MSM) face a disproportionate burden of HIV. Focused, high-coverage PrEP in populations heavily impacted by HIV, such as Black MSM, could rapidly reduce new HIV acquisition rates; however, its uptake among at-risk populations, especially Black MSM, has been limited. Therefore, we propose to conduct urgently needed research on PrEP in a cohort of Black MSM, including on the impact of relevant behaviors, particularly cannabis use, which is highly prevalent in Black MSM. Research on the impact of cannabis use on PrEP has achieved conflicting results, and it has not been rigorously studied in Black MSM. Therefore, the proposed R01 study will assess cross-sectional and longitudinal associations between cannabis use and PrEP outcomes (e.g., use, adherence) and HIV transmission risk (e.g. biological inflammation, sexual risk behavior) using event-level and objective biomarker data among HIV-negative Black SMM. To address these specific aims, we will conduct the Networks and Neighborhoods (N2) Cannabis PrEP Study in Chicago, IL. We will follow 250 HIV-negative participants from the original N2 cohort for an additional one-year period with 3 study waves. We will use innovative and rigorous methods, to collect additional data, such as Ecological Momentary Assessment methods and objective measures of cannabis use, PrEP use, and immune function over 14-day periods at each wave. Potential findings can impact intervention development and implementation, as well as inform policy to increase PrEP uptake and adherence, address substance use, and decrease HIV transmission rates, and disparities.