Cannabis use, PrEP and HIV transmission risk Among Black MSM in Chicago

项目总结 黑人同性恋、双性恋和其他与男性发生性行为的男性(MSM)面临着不成比例的艾滋病毒负担。 在受艾滋病毒严重影响的人群中，如黑人MSM，有重点的、高覆盖率的PrEP可能会迅速 降低新的艾滋病毒获得率；然而，其在高危人群中的感染，特别是黑人MSM，已经 是有限的。因此，我们建议在一群黑人MSM中进行急需的PrEP研究， 包括相关行为的影响，特别是吸食大麻，这在黑人中非常普遍 MSM。关于大麻使用对PrEP的影响的研究取得了相互矛盾的结果，而且还没有 在黑色MSM中严格学习。因此，拟议的R01研究将评估横断面和 大麻使用和PrEP结果(如使用、依从性)和艾滋病毒之间的纵向联系 使用事件级别和客观生物标记物的传播风险(如生物炎症、性风险行为) HIV阴性黑人SMM的数据。为了实现这些具体目标，我们将开展网络和 邻居(N2)伊利诺伊州芝加哥的大麻PrEP研究。我们将跟踪250名HIV阴性的参与者 原始的N_2队列增加了一年的时间，有3个研究波。我们将用创新和严谨 方法，收集其他数据，如生态瞬时评估方法和目标 在每一波的14天期间测量大麻使用、PrEP使用和免疫功能。潜力 调查结果可能会影响干预措施的制定和实施，并为增加PrEP的政策提供信息 吸食和坚持，解决物质使用问题，降低艾滋病毒传播率和差异。

PROJECT SUMMARY Black gay, bisexual and other men who have sex with men (MSM) face a disproportionate burden of HIV. Focused, high-coverage PrEP in populations heavily impacted by HIV, such as Black MSM, could rapidly reduce new HIV acquisition rates; however, its uptake among at-risk populations, especially Black MSM, has been limited. Therefore, we propose to conduct urgently needed research on PrEP in a cohort of Black MSM, including on the impact of relevant behaviors, particularly cannabis use, which is highly prevalent in Black MSM. Research on the impact of cannabis use on PrEP has achieved conflicting results, and it has not been rigorously studied in Black MSM. Therefore, the proposed R01 study will assess cross-sectional and longitudinal associations between cannabis use and PrEP outcomes (e.g., use, adherence) and HIV transmission risk (e.g. biological inflammation, sexual risk behavior) using event-level and objective biomarker data among HIV-negative Black SMM. To address these specific aims, we will conduct the Networks and Neighborhoods (N2) Cannabis PrEP Study in Chicago, IL. We will follow 250 HIV-negative participants from the original N2 cohort for an additional one-year period with 3 study waves. We will use innovative and rigorous methods, to collect additional data, such as Ecological Momentary Assessment methods and objective measures of cannabis use, PrEP use, and immune function over 14-day periods at each wave. Potential findings can impact intervention development and implementation, as well as inform policy to increase PrEP uptake and adherence, address substance use, and decrease HIV transmission rates, and disparities.