Characterizing Sleep, ART Adherence and Viral Suppression Among Black Sexual Minority Men

项目摘要 为了实现拟议研究和RFA-HL-21-018的目标，我们将使用一个多层次的 研究睡眠与艾滋病毒治疗结果和行为之间关系的方法（例如，病毒 在黑人同性恋者、双性恋者和其他 性少数男性（SMM）随访一年以上，以了解干预措施。我们将招募250名黑人SMM， NIH资助的社区和网络（N2）队列研究在拟议的N2睡眠健康研究中， 解决研究的目的。资格要求包括：艾滋病毒血清阳性和自我报告 愿意在一年中的三个时间点佩戴腕关节活动记录仪两周。在这一纵向 在完成最初的2周腕关节活动记录方案后，参与者将携带腕关节活动记录仪， 在为期一年的研究期间，每六个月增加两周，总共三次。客观 在基线测量的睡眠数据可能潜在地影响关于HIV治疗的决策（例如， 抗逆转录病毒治疗[ART]结果），提供了一个明确的时间顺序和能力， 考虑潜在的时间滞后。多层次因素-例如，个人层面的肥胖，亲密伴侣暴力， 与保健服务的空间接近度-可以改变这些关系。这项研究将是第一个 对黑人SMM人群进行客观的睡眠健康研究。拟议研究的结果 这对针对背景适当的睡眠和艾滋病毒干预措施具有重大意义，因为需要 为下一代艾滋病毒干预措施提供信息的新方法（即，长效注射剂），尤其是 黑色SMM。

PROJECT SUMMARY To address the aims of the proposed research and RFA-HL-21-018, we will use a syndemics and multi-level approach to investigate relationships between sleep and HIV treatment outcomes and behaviors (e.g., viral suppression and retention in care) cross-sectionally and longitudinally among Black gay, bisexual and other sexual minority men (SMM) followed over one year to inform interventions. We will enroll 250 Black SMM from the NIH-funded Neighborhoods and Networks (N2) Cohort Study in the proposed N2 Sleep Health Study to address the aims of the research. Eligibility requirements include: HIV-seropositive and self-reported willingness to wear a wrist actigraph for two-weeks at three points over the course of a year. In this longitudinal study, after completing the initial 2-week wrist actigraphy protocol, participants will carry the wrist actigraph for an additional 2-weeks every six-months over the one-year study period—for a total of three times. Objectively measured sleep data at baseline could potentially influence decision-making regarding HIV treatment (e.g., antiretroviral treatment [ART] outcomes) over time, providing a clear temporal ordering and an ability to consider potential time-lags. Multi-level factors – e.g., individual-level obesity, intimate partner violence, and spatial proximity to healthcare services – may modify these relationships. The proposed study will be the first objective sleep health study among any population of Black SMM. Findings from the proposed research have significant implications for targeting contextually appropriate sleep and HIV interventions as there is a need for new approaches to inform the next generation of HIV interventions (i.e., long-acting injectables), especially for Black SMM.