Characterizing Sleep, ART Adherence and Viral Suppression Among Black Sexual Minority Men

黑人性少数男性的睡眠、抗逆转录病毒治疗依从性和病毒抑制特征

• 批准号: 10682533
• 负责人: Dustin T Duncan
• 金额: $ 78.01万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10682533
• 关键词: Address; Adherence; Affect; Behavior; Bisexual; Black Populations; Black race; Body mass index; Caring; Chicago; Clinical; Cohort Studies; Complex; Continuity of Patient Care; Counseling; Data; Decision Making; Dedications; Disparity; Eligibility Determination; Enrollment; Epidemic; Epidemiology; Funding; Gays; General Population; HIV; HIV Infections; HIV Seropositivity; HIV/AIDS; Health Services; Housing; Incidence; Individual; Injectable; Intervention; Link; Longitudinal Studies; Measures; Mental Health; Methodology; Neighborhoods; Obesity; Outcome; Participant; Patient Self-Report; Persons; Polysomnography; Population; Prevention; Prospective, cohort study; Protocols documentation; Research; Sampling; Sleep; Sleep Disorders; Social Environment; Social Network; Time; Translations; Treatment outcome; United States; United States National Institutes of Health; Viral; Viral Load result; Visit; Wrist; actigraphy; antiretroviral therapy; care outcomes; cohort; community violence; comorbidity; contextual factors; experience; follow-up; health care service; health determinants; health inequalities; improved; innovation; intimate partner violence; marginalization; marginalized population; medication compliance; multidisciplinary; next generation; novel strategies; nutrition; poor sleep; primary outcome; racial minority population; secondary outcome; sexual minority group; sexual minority men; skills; sleep health; sleep quality; social epidemiology; social stigma; substance use; substance use treatment; success; syndemic; therapy adherence; trait; transmission process; treatment adherence; willingness

PROJECT SUMMARY To address the aims of the proposed research and RFA-HL-21-018, we will use a syndemics and multi-level approach to investigate relationships between sleep and HIV treatment outcomes and behaviors (e.g., viral suppression and retention in care) cross-sectionally and longitudinally among Black gay, bisexual and other sexual minority men (SMM) followed over one year to inform interventions. We will enroll 250 Black SMM from the NIH-funded Neighborhoods and Networks (N2) Cohort Study in the proposed N2 Sleep Health Study to address the aims of the research. Eligibility requirements include: HIV-seropositive and self-reported willingness to wear a wrist actigraph for two-weeks at three points over the course of a year. In this longitudinal study, after completing the initial 2-week wrist actigraphy protocol, participants will carry the wrist actigraph for an additional 2-weeks every six-months over the one-year study period—for a total of three times. Objectively measured sleep data at baseline could potentially influence decision-making regarding HIV treatment (e.g., antiretroviral treatment [ART] outcomes) over time, providing a clear temporal ordering and an ability to consider potential time-lags. Multi-level factors – e.g., individual-level obesity, intimate partner violence, and spatial proximity to healthcare services – may modify these relationships. The proposed study will be the first objective sleep health study among any population of Black SMM. Findings from the proposed research have significant implications for targeting contextually appropriate sleep and HIV interventions as there is a need for new approaches to inform the next generation of HIV interventions (i.e., long-acting injectables), especially for Black SMM.

项目总结 为了解决拟议研究的目标和RFA-HL-21-018，我们将使用汇聚和多层次 调查睡眠与艾滋病毒治疗结果和行为(例如，病毒)之间的关系的方法 在黑人同性恋者、双性恋者和其他 性少数男性(SMM)跟踪一年多，告知干预措施。我们将从以下地点招收250名黑人SMM 美国国立卫生研究院资助的社区和网络(N2)队列研究在拟议的N2睡眠健康研究中 阐述研究的目的。资格要求包括：艾滋病毒血清阳性和自我报告 愿意在一年的时间里在三个点上佩戴两周的腕表。在这个纵向上 研究表明，在完成最初为期两周的腕部活动记录仪后，参与者将携带腕部活动记录仪 在为期一年的研究期间，每六个月增加两周-总共三次。客观地 在基线上测量的睡眠数据可能潜在地影响关于艾滋病毒治疗的决策(例如， 抗逆转录病毒治疗[ART]结果)随着时间的推移，提供了明确的时间顺序和能力 考虑一下潜在的时间延迟。多层次因素--例如，个人水平的肥胖、亲密伴侣的暴力，以及 与医疗服务的空间接近--可能会改变这些关系。这项拟议的研究将是第一次 目的了解黑人SMM人群的睡眠健康状况。这项拟议的研究的发现 针对背景适当的睡眠和艾滋病毒干预措施的重大影响，因为需要 为下一代艾滋病毒干预措施(即长效注射剂)提供信息的新方法，特别是 黑人SMM。