The Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC)

费城地区中风试验网络协调中心（PRSTNCC）是一个非常有效的 由成人和儿童血管神经学家，神经外科医生， 神经放射科医生、急诊医生、康复专家和其他进行临床试验的专家 专注于中风的治疗、预防和康复。PRSTNCC位于大学 Pennsylvania（Penn），一个位于宾夕法尼亚州费城的城市三级医疗学术医疗中心， 该联盟的“枢纽”，并与费城儿童医院（CHOP）和8 分布在地理位置和种族多样性地区的其他成员医院（“辐条”） 费城（和1个在罗得岛）。因此，PRSTNCC联合了综合中风中心、初级中风中心 中风中心和一个地区儿科中心，为广泛的中风患者提供了一个 由临床医生和研究人员组成的多学科小组。减贫战略、技术和国家协调委员会的首要目标是减少 通过开展跨学科的研究， 对中风治疗、预防和康复的有前景的临床干预试验。 多学科的PRSTNCC领导团队，由首席研究员（PI）斯科特E。Kasner，MD， 进行多中心卒中临床试验的丰富经验，并一直是 现在的NIH StrokeNet。PRSTNCC基础设施支持高效和有效地开展卒中试验 参与医院中。中心提供研究支持和专业知识，特别是在 人类受试者保护和其他监管活动领域，以及临床研究的教育和指导 和研究人员，以努力简化试验实施和加快患者入组。轮毂 为试验执行期间的数据收集和传输提供持续支持，并提供及时反馈 并向成员专家和医院提供有关试验结果的教育，以鼓励研究成果的翻译 结果进入临床实践。此外，我们正在培训新一代的中风研究人员， 通过为他们提供成功进行临床试验所需的知识和技能， 作为独立资助的临床科学家的学术生涯。

The Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC) is a highly effective collaborative stroke research team comprised of adult and pediatric vascular neurologists, neurosurgeons, neuroradiologists, emergency physicians, rehabilitation specialists, and other experts who conduct clinical trials focused on stroke treatment, prevention, and recovery. The PRSTNCC is based at the University of Pennsylvania (Penn), an urban, tertiary care, academic medical center in Philadelphia, PA, which serves as the "Hub" of the consortium, and has joined forces with the Children's Hospital of Philadelphia (CHOP) and 8 additional member hospitals ("Spokes") located in geographically and ethnically diverse areas in and around Philadelphia (and 1 in Rhode Island). The PRSTNCC thereby unites comprehensive stroke centers, primary stroke centers, and a regional pediatric center, providing access to a broad range of patients with stroke to a multidisciplinary group of clinicians and researchers. The overarching goal of the PRSTNCC is to reduce the burden of stroke among patients of all ages and backgrounds within this region by conducting interdisciplinary trials of promising clinical interventions for stroke treatment, prevention, and recovery. The multi-disciplinary PRSTNCC leadership team, led by Principal Investigator (PI) Scott E. Kasner, MD, has extensive experience conducting multi-center stroke clinical trials, and has been a leading enroller for the current NIH StrokeNet. The PRSTNCC infrastructure supports efficient and effective conduct of stroke trials among the participant hospitals. Research support and expertise are provided by the Hub, particularly in the areas of human subjects protections and other regulatory activities, and education and orientation of clinical and research staff in an effort to streamline trial implementation and expedite patient enrollment. The Hub provides ongoing support for data collection and transfer during trial execution, and provides timely feedback and education about trial results to member specialists and hospitals to encourage translation of research results into clinical practice. In addition, we are training a new generation of stroke researchers in the conduct and design of clinical trials by providing them with the knowledge and skills necessary for a successful academic career as independently-funded clinician-scientists.