The Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC)

费城地区卒中试验网络协调中心 (PRSTNCC)

• 批准号: 10760579
• 负责人: SCOTT E KASNER
• 金额: $ 17.46万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-13 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10760579
• 关键词: Academic Medical Centers; Acute; Adult; Age; Area; Blood Vessels; Cause of Death; Child; Childhood; Clinical; Clinical Trials; Clinical Trials Design; Conduct Clinical Trials; Data Collection; Disease; Education; Emergency Department Physician; Feedback; Funding; Generations; Geography; Goals; Hospitals; Infrastructure; Knowledge; Leadership; Neurologist; Neurosurgeon; Participant; Patients; Pediatric Hospitals; Pennsylvania; Philadelphia; Prevention; Prevention therapy; Principal Investigator; Public Health; Recovery; Rehabilitation therapy; Research; Research Personnel; Research Support; Rhode Island; Scientist; Specialist; Stroke; Training; Translational Research; United States; United States National Institutes of Health; Universities; career; clinical practice; data exchange; ethnic diversity; experience; human subject protection; member; multidisciplinary; novel therapeutics; participant enrollment; skills; stroke clinical trials; stroke intervention; stroke therapy; stroke trials; tertiary care

PROJECT SUMMARY/ABSTRACT The Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC) is a highly effective collaborative stroke research team comprised of adult and pediatric vascular neurologists, neurosurgeons, neuroradiologists, emergency physicians, rehabilitation specialists, and other experts who conduct clinical trials focused on stroke treatment, prevention, and recovery. The PRSTNCC is based at the University of Pennsylvania (Penn), an urban, tertiary care, academic medical center in Philadelphia, PA, which serves as the "Hub" of the consortium, and has joined forces with the Children's Hospital of Philadelphia (CHOP) and 8 additional member hospitals ("Spokes") located in geographically and ethnically diverse areas in and around Philadelphia (and 1 in Rhode Island). The PRSTNCC thereby unites comprehensive stroke centers, primary stroke centers, and a regional pediatric center, providing access to a broad range of patients with stroke to a multidisciplinary group of clinicians and researchers. The overarching goal of the PRSTNCC is to reduce the burden of stroke among patients of all ages and backgrounds within this region by conducting interdisciplinary trials of promising clinical interventions for stroke treatment, prevention, and recovery. The multi-disciplinary PRSTNCC leadership team, led by Principal Investigator (PI) Scott E. Kasner, MD, has extensive experience conducting multi-center stroke clinical trials, and has been a leading enroller for the current NIH StrokeNet. The PRSTNCC infrastructure supports efficient and effective conduct of stroke trials among the participant hospitals. Research support and expertise are provided by the Hub, particularly in the areas of human subjects protections and other regulatory activities, and education and orientation of clinical and research staff in an effort to streamline trial implementation and expedite patient enrollment. The Hub provides ongoing support for data collection and transfer during trial execution, and provides timely feedback and education about trial results to member specialists and hospitals to encourage translation of research results into clinical practice. In addition, we are training a new generation of stroke researchers in the conduct and design of clinical trials by providing them with the knowledge and skills necessary for a successful academic career as independently-funded clinician-scientists.

项目概要/摘要 费城地区卒中试验网络协调中心 (PRSTNCC) 是一个高效的 中风协作研究小组由成人和儿童血管神经科医生、神经外科医生、 神经放射科医生、急诊科医生、康复专家和其他进行临床试验的专家 专注于中风的治疗、预防和康复。 PRSTNCC 设在大学 宾夕法尼亚州 (Penn) 是位于宾夕法尼亚州费城的一个城市三级护理学术医疗中心， 该联盟的“枢纽”，并与费城儿童医院 (CHOP) 和 8 其他成员医院（“辐条医院”）位于境内及周边地区和种族不同的地区 费城（以及罗德岛州 1 个）。 PRSTNCC 从而将综合卒中中心、初级卒中中心联合起来 中风中心和地区儿科中心，为广大中风患者提供就诊服务 由临床医生和研究人员组成的多学科小组。 PRSTNCC 的总体目标是减少 通过跨学科研究，评估该地区所有年龄和背景的患者的中风负担 对中风治疗、预防和康复有希望的临床干预措施的试验。 由首席研究员 (PI) Scott E. Kasner 医学博士领导的多学科 PRSTNCC 领导团队已 在进行多中心卒中临床试验方面拥有丰富的经验，并且一直是该项目的主要招募者 当前的 NIH StrokeNet。 PRSTNCC 基础设施支持高效且有效地进行中风试验 参与医院中。该中心提供研究支持和专业知识，特别是在 人类受试者保护和其他监管活动以及临床教育和指导领域 和研究人员，努力简化试验实施并加快患者入组。枢纽 为试验执行过程中的数据收集和传输提供持续支持，并提供及时反馈 向成员专家和医院提供有关试验结果的教育，以鼓励研究成果转化 结果进入临床实践。此外，我们正在培训新一代中风研究人员进行 和设计临床试验，为他们提供成功所需的知识和技能 作为独立资助的临床医生科学家的学术生涯。