The Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC)

费城地区卒中试验网络协调中心 (PRSTNCC)

• 批准号: 10760579
• 负责人: SCOTT E KASNER
• 金额: $ 17.46万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-13 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10760579
• 关键词: Academic Medical Centers; Acute; Adult; Age; Area; Blood Vessels; Cause of Death; Child; Childhood; Clinical; Clinical Trials; Clinical Trials Design; Conduct Clinical Trials; Data Collection; Disease; Education; Emergency Department Physician; Feedback; Funding; Generations; Geography; Goals; Hospitals; Infrastructure; Knowledge; Leadership; Neurologist; Neurosurgeon; Participant; Patients; Pediatric Hospitals; Pennsylvania; Philadelphia; Prevention; Prevention therapy; Principal Investigator; Public Health; Recovery; Rehabilitation therapy; Research; Research Personnel; Research Support; Rhode Island; Scientist; Specialist; Stroke; Training; Translational Research; United States; United States National Institutes of Health; Universities; career; clinical practice; data exchange; ethnic diversity; experience; human subject protection; member; multidisciplinary; novel therapeutics; participant enrollment; skills; stroke clinical trials; stroke intervention; stroke therapy; stroke trials; tertiary care

PROJECT SUMMARY/ABSTRACT The Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC) is a highly effective collaborative stroke research team comprised of adult and pediatric vascular neurologists, neurosurgeons, neuroradiologists, emergency physicians, rehabilitation specialists, and other experts who conduct clinical trials focused on stroke treatment, prevention, and recovery. The PRSTNCC is based at the University of Pennsylvania (Penn), an urban, tertiary care, academic medical center in Philadelphia, PA, which serves as the "Hub" of the consortium, and has joined forces with the Children's Hospital of Philadelphia (CHOP) and 8 additional member hospitals ("Spokes") located in geographically and ethnically diverse areas in and around Philadelphia (and 1 in Rhode Island). The PRSTNCC thereby unites comprehensive stroke centers, primary stroke centers, and a regional pediatric center, providing access to a broad range of patients with stroke to a multidisciplinary group of clinicians and researchers. The overarching goal of the PRSTNCC is to reduce the burden of stroke among patients of all ages and backgrounds within this region by conducting interdisciplinary trials of promising clinical interventions for stroke treatment, prevention, and recovery. The multi-disciplinary PRSTNCC leadership team, led by Principal Investigator (PI) Scott E. Kasner, MD, has extensive experience conducting multi-center stroke clinical trials, and has been a leading enroller for the current NIH StrokeNet. The PRSTNCC infrastructure supports efficient and effective conduct of stroke trials among the participant hospitals. Research support and expertise are provided by the Hub, particularly in the areas of human subjects protections and other regulatory activities, and education and orientation of clinical and research staff in an effort to streamline trial implementation and expedite patient enrollment. The Hub provides ongoing support for data collection and transfer during trial execution, and provides timely feedback and education about trial results to member specialists and hospitals to encourage translation of research results into clinical practice. In addition, we are training a new generation of stroke researchers in the conduct and design of clinical trials by providing them with the knowledge and skills necessary for a successful academic career as independently-funded clinician-scientists.

项目摘要/摘要 费城地区中风试验网络协调中心(PRSTNCC)是一家高效的 由成人和儿童血管神经学家、神经外科医生、 神经放射科医生、急诊医生、康复专家和其他进行临床试验的专家 专注于中风的治疗、预防和康复。PRSTNCC的总部设在加州大学 宾夕法尼亚州(宾夕法尼亚州)，宾夕法尼亚州费城的一个城市，三级护理，学术医疗中心，提供 该联盟的“枢纽”，并已与费城儿童医院(CHOP)和8 位于地理和种族不同地区的其他成员医院(Spokes)及其周围 费城(罗德岛有1个)。因此，PRSTNCC将综合卒中中心、初级卒中中心 中风中心和地区性儿科中心，为范围广泛的中风患者提供 临床医生和研究人员组成的多学科小组。PRSTNCC的总体目标是减少 在本地区所有年龄和背景的患者中进行跨学科研究的卒中负担 中风治疗、预防和康复的有前景的临床干预试验。 由首席调查员(PI)Scott E.Kasner，MD领导的多学科PRSTNCC领导团队已经 具有丰富的进行多中心卒中临床试验的经验，并一直是 目前的NIH StrokeNet。PRSTNCC基础设施支持高效和有效地进行中风试验 在参与的医院中。研究支持和专业知识由中心提供，特别是在 人类受试者保护和其他监管活动领域，以及临床教育和指导 和研究人员，努力简化试验实施和加快患者登记。The Hub 为试运行期间的数据收集和传输提供持续支持，并提供及时反馈 并对成员专家和医院进行关于试验结果的教育，以鼓励研究成果的翻译 结果应用于临床实践。此外，我们正在培训新一代中风研究人员在 以及设计临床试验，为他们提供成功的 学术生涯为独立资助的临床医生-科学家。