The Philadelphia Regional Stroke Trials Network coordinating Center (PRSTNCC)

费城地区卒中试验网络协调中心 (PRSTNCC)

• 批准号: 9324041
• 负责人: SCOTT E KASNER
• 金额: $ 38.77万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9324041
• 关键词: Academic Medical Centers; Adult; Age; Area; Blood Vessels; Cause of Death; Cerebrovascular Disorders; Certification; Child; Childhood; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Communication; Conduct Clinical Trials; Data; Data Collection; Development; Discipline; Disease; Education; Eligibility Determination; Emergency Department Physician; Enrollment; Feedback; Funding; Future; Generations; Geography; Goals; Hospitals; Intervention; Knowledge; Leadership; Mentors; Mission; Monitor; Neurological emergencies; Neurologist; Neurosurgeon; New Jersey; Participant; Patient Recruitments; Patients; Pediatric Hospitals; Pennsylvania; Phase; Philadelphia; Positioning Attribute; Prevention; Principal Investigator; Procedures; Productivity; Prospective Studies; Protocols documentation; Public Health; Recovery; Recruitment Activity; Rehabilitation therapy; Research; Research Ethics; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Scientist; Site; Specialist; Stroke; Stroke prevention; Structure; Talents; Thrombosis; Time; Training; Training and Education; Translational Research; United States; Universities; Work; base; career; cerebral vein; clinical biomarkers; clinical practice; data management; ethnic diversity; experience; follow-up; human subject protection; innovation; member; multidisciplinary; neonate; novel therapeutics; operation; patient population; programs; public health relevance; skills; stroke intervention; stroke treatment; suburb; tertiary care; treatment trial; validation studies

DESCRIPTION (provided by applicant): The proposed Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC) will be a highly effective collaborative stroke research team comprised of adult and pediatric vascular neurologists, neurosurgeons, neuroradiologists, emergency physicians, rehabilitation specialists, and other experts who conduct clinical trials focused on stroke treatment, prevention, and recovery. The PRSTNCC will be based at the University of Pennsylvania (Penn), an urban, tertiary care, academic medical center in Philadelphia, PA, which will serve as the "Hub" of the consortium, and will join forces with the Children's Hospital of Philadelphia (CHOP) and 4 additional member hospitals ("Spokes") located in geographically and ethnically diverse areas in and around Philadelphia. The PRSTNCC thereby unites a comprehensive stroke center, primary stroke centers, and a regional pediatric center, providing access to a broad range of patients with stroke to a multidisciplinary group of clinicians and researchers. The overarching goal of the PRSTNCC is to reduce the burden of stroke among patients of all ages and backgrounds within this region by conducting interdisciplinary trials of promising clinical interventions for stroke treatment, prevention, and recovery. The multi-disciplinary PRSTNCC leadership team, led by Principal Investigator (PI) Scott E. Kasner, MD, has extensive experience conducting multi-center stroke clinical trials, including Cooperative Group trials. The PRSTNCC aims to build on our leadership position within the Greater Philadelphia Southern New Jersey Neurologic Emergencies Treatment Trials Network (GPSNJ-NETT) by creating a similar infrastructure for the efficient conduct of stroke trials among the participant hospitals that are most successful in conducting stroke research. Research support and expertise will be provided by the Hub, particularly in the areas of human subjects protections and other regulatory activities, and education and orientation of clinical and research staff in an effort to streamline trial implementation and expedite patient enrollment. The Hub will provide ongoing support for data collection and transfer during trial execution, and will provide timely feedback and education about trial results to member specialists and hospitals to encourage translation of research results into clinical practice. In addition, we aim to train a new generation of stroke researchers in the conduct and design of clinical trials by providing them with the knowledge and skills necessary for a successful academic career as independently-funded clinician-scientists.

描述（由申请人提供）：拟议的费城地区卒中试验网络协调中心（PRSTNCC）将是一个高效的卒中协作研究团队，由成人和儿童血管神经学家、神经外科医生、神经放射学家、急诊医生、康复专家和其他开展卒中治疗、预防和康复临床试验的专家组成。PRSTNCC将设在宾夕法尼亚大学（Penn），这是一个位于宾夕法尼亚州费城的城市三级医疗学术医疗中心，将作为联盟的“枢纽”，并将与费城儿童医院（CHOP）和位于费城及其周边地理和种族多样化地区的4家其他成员医院（“辐条”）联手。因此，PRSTNCC联合了一个综合性卒中中心、一个初级卒中中心和一个区域儿科中心，为多学科的临床医生和研究人员提供了接触广泛卒中患者的机会。PRSTNCC的总体目标是通过开展有前景的卒中治疗、预防和康复临床干预措施的跨学科试验，减轻该地区所有年龄和背景患者的卒中负担。多学科的PRSTNCC领导团队，由首席研究员（PI）斯科特E。Kasner博士在开展多中心卒中临床试验（包括协作组试验）方面拥有丰富的经验。PRSTNCC旨在通过创建一个类似的基础设施，在参与卒中研究最成功的医院中有效开展卒中试验，从而巩固我们在大费城南部新泽西神经系统急症治疗试验网络（GPSNJ-NETT）中的领导地位。中心将提供研究支持和专业知识，特别是在人类受试者保护和其他监管活动领域，以及临床和研究人员的教育和指导，以简化试验实施并加快患者入组。该中心将在试验执行期间为数据收集和传输提供持续支持，并将提供有关试验结果的及时反馈和教育 鼓励会员专家和医院将研究成果转化为临床实践。此外，我们的目标是通过为他们提供作为独立资助的临床科学家成功学术生涯所需的知识和技能，培训新一代中风研究人员进行和设计临床试验。