The Philadelphia Regional Stroke Trials Network coordinating Center (PRSTNCC)

费城地区卒中试验网络协调中心 (PRSTNCC)

基本信息

批准号：
8739335
负责人：
SCOTT E KASNER
金额：
$ 39.17万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-30 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8739335
关键词：
Academic Medical Centers Adult Age Area Biological Markers Blood Vessels Cause of Death Cerebrovascular Disorders Child Childhood Clinical Clinical Research Clinical Trials Clinical Trials Design Commit Communication Conduct Clinical Trials Data Data Collection Development Discipline Disease Education Emergency Department Physician Emergency treatment Enrollment Feedback Funding Future Generations Goals Hospitals Intervention Knowledge Leadership Mentors Mission Monitor Neurological emergencies Neurologist Neurosurgeon New Jersey Participant Patient Recruitments Patient Transfer Patients Pediatric Hospitals Pennsylvania Phase Philadelphia Positioning Attribute Prevention Principal Investigator Procedures Productivity Prospective Studies Protocols documentation Public Health Recovery Recruitment Activity Rehabilitation therapy Research Research Ethics Research Infrastructure Research Personnel Research Project Grants Research Support Research Training Resources Scientist Site Specialist Stroke Stroke prevention Structure Thrombosis Training Training and Education Translational Research United States Universities Work base career cerebral vein clinical practice data management experience follow-up human subject protection implementation trial innovation member multidisciplinary neonate operation patient population programs public health relevance skills suburb tertiary care treatment trial validation studies

项目摘要

DESCRIPTION (provided by applicant): The proposed Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC) will be a highly effective collaborative stroke research team comprised of adult and pediatric vascular neurologists, neurosurgeons, neuroradiologists, emergency physicians, rehabilitation specialists, and other experts who conduct clinical trials focused on stroke treatment, prevention, and recovery. The PRSTNCC will be based at the University of Pennsylvania (Penn), an urban, tertiary care, academic medical center in Philadelphia, PA, which will serve as the "Hub" of the consortium, and will join forces with the Children's Hospital of Philadelphia (CHOP) and 4 additional member hospitals ("Spokes") located in geographically and ethnically diverse areas in and around Philadelphia. The PRSTNCC thereby unites a comprehensive stroke center, primary stroke centers, and a regional pediatric center, providing access to a broad range of patients with stroke to a multidisciplinary group of clinicians and researchers. The overarching goal of the PRSTNCC is to reduce the burden of stroke among patients of all ages and backgrounds within this region by conducting interdisciplinary trials of promising clinical interventions for stroke treatment, prevention, and recovery. The multi-disciplinary PRSTNCC leadership team, led by Principal Investigator (PI) Scott E. Kasner, MD, has extensive experience conducting multi-center stroke clinical trials, including Cooperative Group trials. The PRSTNCC aims to build on our leadership position within the Greater Philadelphia Southern New Jersey Neurologic Emergencies Treatment Trials Network (GPSNJ-NETT) by creating a similar infrastructure for the efficient conduct of stroke trials among the participant hospitals that are most successful in conducting stroke research. Research support and expertise will be provided by the Hub, particularly in the areas of human subjects protections and other regulatory activities, and education and orientation of clinical and research staff in an effort to streamline trial implementation and expedite patient enrollment. The Hub will provide ongoing support for data collection and transfer during trial execution, and will provide timely feedback and education about trial results to member specialists and hospitals to encourage translation of research results into clinical practice. In addition, we aim to train a new generation of stroke researchers in the conduct and design of clinical trials by providing them with the knowledge and skills necessary for a successful academic career as independently-funded clinician-scientists.

描述（由申请人提供）：拟议的费城区域中风试验网络协调中心（PRSTNCC）将是一个非常有效的协作中风研究小组，由成人和儿科血管神经科医生，神经外科医生，神经读神经学家，神经辐射学家，急诊物理学家，紧急物理学，急诊专家以及其他专业培训进行培训，并进行临时试验。 PRSTNCC将位于宾夕法尼亚州费城的城市，三级护理，宾夕法尼亚大学的学术医学中心，将作为宾夕法尼亚州的学术医学中心，该中心将作为联盟的“枢纽”，并将与费城（Philadelphia（Chop）的儿童医院（Chop）和4个其他成员院（“ Spokes”（Sopokes）（“ Spokes”（Sokokes）围绕地理和Etheria，并在Etheria中及其及其不同的地区和诺斯（Ethe）和诺斯（Ethe）和诺斯（Ethe）和诺斯（Ethe）和诺斯（Ethe）和诺斯（Ethe），并在Etherlia中及其及其各地。 PRSTNCC因此将一个全面的中风中心，主要中风中心和一个区域儿科中心团结起来，为多学科的临床医生和研究人员提供了广泛的中风患者的机会。 PRSTNCC的总体目标是通过进行有希望的中风治疗，预防和康复的有希望的临床干预措施进行跨学科试验，从而减轻该地区各个年龄段和背景的中风负担。由主要研究员（PI）Scott E. Kasner，医学博士领导的多学科PRSTNCC领导团队拥有丰富的经验，进行了多中心中风临床试验，包括合作小组试验。 PRSTNCC旨在以我们在大费城南部新泽西州神经系统紧急情况治疗试验网络（GPSNJ-NETT）的领导地位建立领导地位，通过为在参与者医院中有效进行中风试验的有效进行，这些基础设施类似，这些基础设施在参与医院中最成功。枢纽将提供研究支持和专业知识，尤其是在人类受试者保护和其他监管活动的领域，以及临床和研究人员的教育和方向，以简化试验实施并加快患者入学率。该枢纽将在试用执行过程中为数据收集和转移提供持续的支持，并将提供有关试验结果的及时反馈和教育成员专家和医院，鼓励将研究结果转化为临床实践。此外，我们旨在通过为他们作为独立资助的临床医生成功的学术生涯提供成功的知识和技能来培训新一代中风研究人员的临床试验行为和设计。