The Philadelphia Regional Stroke Trials Network coordinating Center (PRSTNCC)

描述(申请人提供)：拟建的费城地区卒中试验网络协调中心(PRSTNCC)将是一个高效的协作卒中研究团队，由成人和儿童血管神经学家、神经外科医生、神经放射科医生、急诊医生、康复专家和其他专家组成，他们进行专注于中风治疗、预防和康复的临床试验。PRSTNCC的总部将设在宾夕法尼亚州费城的城市、三级保健和学术医疗中心宾夕法尼亚大学(Penn)，该中心将作为该财团的“枢纽”，并将与费城儿童医院(CHOP)和位于费城及其周边地区的另外4家成员医院(“Spokes”)联手。因此，PRSTNCC将综合中风中心、初级中风中心和地区性儿科中心统一起来，为范围广泛的中风患者提供与多学科临床医生和研究人员的联系。PRSTNCC的总体目标是通过对有望用于中风治疗、预防和康复的临床干预措施进行跨学科试验，减轻该地区所有年龄和背景的患者的中风负担。由首席调查员Scott E.Kasner医学博士领导的多学科PRSTNCC领导团队拥有丰富的管理多中心卒中临床试验的经验，包括合作组试验。PRSTNCC旨在通过创建类似的基础设施，在最成功进行中风研究的参与医院之间高效地进行中风试验，从而巩固我们在大费城南部新泽西州神经紧急情况治疗试验网络(GPSNJ-NETT)中的领导地位。该中心将提供研究支持和专门知识，特别是在人类受试者保护和其他监管活动领域，以及临床和研究人员的教育和指导方面，以努力简化试验实施和加快患者登记。该中心将为试验执行期间的数据收集和传输提供持续支助，并将就试验结果及时提供反馈和教育 鼓励成员专家和医院将研究成果转化为临床实践。此外，我们的目标是培训新一代中风研究人员进行和设计临床试验，为他们提供成功的学术生涯所需的知识和技能，成为独立资助的临床医生和科学家。

DESCRIPTION (provided by applicant): The proposed Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC) will be a highly effective collaborative stroke research team comprised of adult and pediatric vascular neurologists, neurosurgeons, neuroradiologists, emergency physicians, rehabilitation specialists, and other experts who conduct clinical trials focused on stroke treatment, prevention, and recovery. The PRSTNCC will be based at the University of Pennsylvania (Penn), an urban, tertiary care, academic medical center in Philadelphia, PA, which will serve as the "Hub" of the consortium, and will join forces with the Children's Hospital of Philadelphia (CHOP) and 4 additional member hospitals ("Spokes") located in geographically and ethnically diverse areas in and around Philadelphia. The PRSTNCC thereby unites a comprehensive stroke center, primary stroke centers, and a regional pediatric center, providing access to a broad range of patients with stroke to a multidisciplinary group of clinicians and researchers. The overarching goal of the PRSTNCC is to reduce the burden of stroke among patients of all ages and backgrounds within this region by conducting interdisciplinary trials of promising clinical interventions for stroke treatment, prevention, and recovery. The multi-disciplinary PRSTNCC leadership team, led by Principal Investigator (PI) Scott E. Kasner, MD, has extensive experience conducting multi-center stroke clinical trials, including Cooperative Group trials. The PRSTNCC aims to build on our leadership position within the Greater Philadelphia Southern New Jersey Neurologic Emergencies Treatment Trials Network (GPSNJ-NETT) by creating a similar infrastructure for the efficient conduct of stroke trials among the participant hospitals that are most successful in conducting stroke research. Research support and expertise will be provided by the Hub, particularly in the areas of human subjects protections and other regulatory activities, and education and orientation of clinical and research staff in an effort to streamline trial implementation and expedite patient enrollment. The Hub will provide ongoing support for data collection and transfer during trial execution, and will provide timely feedback and education about trial results to member specialists and hospitals to encourage translation of research results into clinical practice. In addition, we aim to train a new generation of stroke researchers in the conduct and design of clinical trials by providing them with the knowledge and skills necessary for a successful academic career as independently-funded clinician-scientists.