The Philadelphia Regional Stroke Trials Network coordinating Center (PRSTNCC)

描述（由申请人提供）：拟建的费城区域卒中试验网络协调中心（PRSTNCC）将是一个高效的卒中合作研究团队，由成人和儿童血管神经科医生、神经外科医生、神经放射科医生、急诊医生、康复专家和其他专家组成，他们将开展以卒中治疗、预防和康复为重点的临床试验。PRSTNCC将以宾夕法尼亚大学（Penn）为基地，宾夕法尼亚大学是宾夕法尼亚州费城的一个城市三级保健学术医疗中心，它将作为联盟的“枢纽”，并将与费城儿童医院（CHOP）和位于费城及其周边地理和种族多样化地区的另外4家成员医院（“辐条”）联合起来。因此，PRSTNCC联合了一个综合中风中心、初级中风中心和一个地区儿科中心，为多学科临床医生和研究人员提供广泛的中风患者。PRSTNCC的首要目标是通过开展有前景的卒中治疗、预防和康复临床干预的跨学科试验，减轻该地区所有年龄和背景的患者的卒中负担。由首席研究员Scott E. Kasner博士领导的多学科PRSTNCC领导团队在开展多中心卒中临床试验（包括合作小组试验）方面拥有丰富的经验。PRSTNCC的目标是建立我们在大费城新泽西州南部神经急救治疗试验网络（GPSNJ-NETT）中的领导地位，通过创建类似的基础设施，在参与中风研究最成功的医院之间有效地进行中风试验。该中心将提供研究支持和专业知识，特别是在人体受试者保护和其他监管活动领域，以及临床和研究人员的教育和指导，以简化试验实施和加快患者入组。该中心将在试验执行期间为数据收集和转移提供持续支持，并将提供有关试验结果的及时反馈和教育

DESCRIPTION (provided by applicant): The proposed Philadelphia Regional Stroke Trials Network Coordinating Center (PRSTNCC) will be a highly effective collaborative stroke research team comprised of adult and pediatric vascular neurologists, neurosurgeons, neuroradiologists, emergency physicians, rehabilitation specialists, and other experts who conduct clinical trials focused on stroke treatment, prevention, and recovery. The PRSTNCC will be based at the University of Pennsylvania (Penn), an urban, tertiary care, academic medical center in Philadelphia, PA, which will serve as the "Hub" of the consortium, and will join forces with the Children's Hospital of Philadelphia (CHOP) and 4 additional member hospitals ("Spokes") located in geographically and ethnically diverse areas in and around Philadelphia. The PRSTNCC thereby unites a comprehensive stroke center, primary stroke centers, and a regional pediatric center, providing access to a broad range of patients with stroke to a multidisciplinary group of clinicians and researchers. The overarching goal of the PRSTNCC is to reduce the burden of stroke among patients of all ages and backgrounds within this region by conducting interdisciplinary trials of promising clinical interventions for stroke treatment, prevention, and recovery. The multi-disciplinary PRSTNCC leadership team, led by Principal Investigator (PI) Scott E. Kasner, MD, has extensive experience conducting multi-center stroke clinical trials, including Cooperative Group trials. The PRSTNCC aims to build on our leadership position within the Greater Philadelphia Southern New Jersey Neurologic Emergencies Treatment Trials Network (GPSNJ-NETT) by creating a similar infrastructure for the efficient conduct of stroke trials among the participant hospitals that are most successful in conducting stroke research. Research support and expertise will be provided by the Hub, particularly in the areas of human subjects protections and other regulatory activities, and education and orientation of clinical and research staff in an effort to streamline trial implementation and expedite patient enrollment. The Hub will provide ongoing support for data collection and transfer during trial execution, and will provide timely feedback and education about trial results to member specialists and hospitals to encourage translation of research results into clinical practice. In addition, we aim to train a new generation of stroke researchers in the conduct and design of clinical trials by providing them with the knowledge and skills necessary for a successful academic career as independently-funded clinician-scientists.