Seeing is believing: Microscopy-capable single-molecule bioelectronics

眼见为实：具有显微镜功能的单分子生物电子学

• 批准号: DP210102085
• 负责人: Prof Adam Micolich
• 金额: $ 31.65万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-05-24 至 2025-05-23
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210102085
• 关键词: Seeing; believing; Microscopy; capable; single

This project aims to create new biophysical tools for single-molecule sensing by advancing the state-of-the-art in nanoscale bioelectronic devices. The goal is to generate novel bioelectronic devices optimised for fabrication on microscope coverslip (170 micron glass) for compatibility with new low-cost platforms for advanced biological microscopy. Expected outcomes include the first organic electrochemical transistors interfaced to constrained area lipid bilayers for studying membrane proteins at single-molecule level and nanoscale transistors for electrostatically detecting motile microtubules in in-vitro molecular motor assays for biocomputation. The intended benefit is innovation in capabilities and manufacturing of bioelectronics.

该项目旨在通过推进纳米生物电子器件的最新技术，为单分子传感创造新的生物物理工具。其目标是产生新型生物电子器件，优化用于在显微镜盖玻片（170微米玻璃）上制造，以与先进生物显微镜的新低成本平台兼容。预期成果包括第一个有机电化学晶体管接口的限制面积脂质双层研究膜蛋白在单分子水平和纳米级晶体管的静电检测运动微管在体外分子马达测定生物计算。预期的好处是在生物电子的能力和制造方面的创新。