Predictors of Speech Ability in Children with Down Syndrome

唐氏综合症儿童言语能力的预测因素

• 批准号: 10316884
• 负责人: Stephen Mark Camarata
• 金额: $ 48.32万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10316884
• 关键词: Academy; Accent; Accounting; Acoustics; Adolescence; Age; Articulation; Articulators; Biological Assay; Birth; Child; Clinical; Clinical Trials; Cognitive; Communication; Comprehension; Data; Development; Down Syndrome; Frequencies; Future; Goals; Growth; Human; Individual; Intervention; Intervention Studies; Investigational Therapies; Language; Language Disorders; Learning; Linguistics; Literature; Longitudinal Studies; Measures; Medicine; Modeling; Motor; Motor Skills; Outcome; Paper; Participant; Periodicity; Process; Production; Reading; Reporting; Research; Research Project Grants; School-Age Population; Series; Speech; Speech Development; Speech Disorders; Speech Intelligibility; Structure; Students; Testing; Translational Research; Variant; Vocabulary; Work; base; cognitive ability; design; experience; improved; insight; lexical; oral motor; phonology; post intervention; prospective; reading ability; skills; speech accuracy; therapy design

ABSTRACT Speech is a critical aspect of the human experience and usually develops in a “seemingly automatic process that continues from birth through adolescence (p.1, NAM, 2016)” and underlies many related abilities (e.g., language and reading, see National Academy of Medicine Report on Speech and Language Disorders, 2016). Many individuals with Down Syndrome (Trisomy 21, DS) struggle to communicate and participate more fully in human communication and educational learning experiences because their speech is difficult to understand. The purpose of the proposed project is to measure speech-articulation accuracy and speech intelligibility, and their proposed primary predictors at study entry in 20 children with DS age 7;0 to 12;11. A validated treatment, speech recast intervention (see Yoder, Camarata & Woynaroski, 2016) will be used to drive growth in speech intelligibility as a means of evaluating changes in potential sequelae of change. This integrated study will include measures of speech- articulation accuracy, speech-prosody, general cognitive ability, receptive vocabulary skills, and clinical assay of oral-motor ability as potential predictors of speech intelligibility growth in DS. We will also be measuring suprasegmental and rhythmic factors associated with growth. The results of this study will provide important information on factors that contribute to intelligible speech in DS and subsequently provide the basis for refining and future intervention investigations of treatment for speech deficits in children with DS.

摘要 言语是人类经验的一个重要方面，通常以“看似”的方式发展。 从出生到青春期持续的自动过程（p.1，NAM，2016）”， 是许多相关能力的基础（例如，语言和阅读，见国家医学科学院 言语和语言障碍报告，2016年）。许多唐氏综合症患者 （21三体，DS）努力沟通，更充分地参与人类沟通 和教育学习经验，因为他们的讲话是难以理解的。的 拟议项目的目的是测量语音清晰度的准确性和语音 在20名7岁的DS儿童中， 到12;11.一个有效的治疗，言语重塑干预（见约德，卡马拉塔和 Woynaroski，2016）将用于推动语音清晰度的增长，作为评估 变化的潜在后遗症的变化。这项综合研究将包括言语的测量- 发音准确性，语音韵律，一般认知能力，接受性词汇技能， 口腔运动能力的临床测定作为DS语言清晰度增长的潜在预测因素。 我们还将测量与生长相关的超音段和节奏因素。的 这项研究的结果将提供重要的信息因素，有助于理解 在DS中的演讲，并随后为改进和未来的干预提供基础 DS儿童言语障碍治疗的研究。