Evaluation of Sensory Integration Treatment in ASD

描述（由申请人提供）：如申请请求中所述，自闭症谱系障碍（ASD）异质性的一个关键方面是通常提供的临床干预措施相对较多，但支持实施的客观证据有限甚至没有。感觉统合失调（SID）是一个有争议的，但广泛使用的诊断分类ASD和感觉统合治疗（SIT），现在常规提供给自闭症谱系障碍的儿童，但有一个非常有限的证据基础。这项R34提案的目的是完成发育分析，为一项相对较大的随机对照试验做准备，该试验旨在研究通常实施的感觉统合治疗技术对ASD沟通发育的影响。共有40名ASD参与者将被随机分配到感觉统合（SIT）或关键反应训练（PRT）比较条件。此外，将收集和分析干预前后多感觉处理的行为和神经成像测量，以确定多感觉处理的变化是否与SIT干预相关。需要两年的支持。 公共卫生相关性：患有自闭症谱系障碍（ASD）的儿童在沟通和社交方面表现出严重的中断。有许多未经证实的治疗方法被认为可以提高广泛实施的技能。本项目的目的是评估感觉统合治疗是否与ASD儿童沟通和社交技能的改善有关。

DESCRIPTION (provided by applicant): As noted in the request for applications, a key aspect of heterogeneity in autism spectrum disorders (ASD) is a relatively high number of clinical interventions that are commonly provided but have limited or even no objective evidence to support implementation. Sensory integration deficit (SID) is a controversial but widely used diagnostic classification in ASD and sensory integration based treatment (SIT) is now routinely provided to children with autism spectrum disorder, but has an extremely limited evidence base. The purpose of this R34 proposal will be to complete developmental analyses in preparation for a relatively large randomized comparison trial examining the effects of commonly implemented sensory integration treatment techniques on communication development in ASD. A total of 40 participants with ASD will be randomly assigned to either a sensory integration (SIT) or pivotal response training (PRT) comparison condition. In addition, pre-and post intervention behavioral and neuro-imaging measures of multi-sensory processing will be gathered and analyzed to determine whether changes in multi-sensory processing are associated with SIT intervention. Two years of support are requested. PUBLIC HEALTH RELEVANCE: Children with autism spectrum disorder (ASD) display severe disruptions in communication and social interaction. There are many unproven treatments thought to improve the skills that are widely implemented. The purpose of this project will be to evaluate whether sensory integration treatment is associated with improvements in communication and social skills in children with ASD.