Image-Guided Cochlear Implant Programming: Pediatric Speech, Language, and Literacy

图像引导人工耳蜗编程：儿科言语、语言和读写能力

• 批准号: 10375414
• 负责人: Stephen Mark Camarata
• 金额: $ 45.07万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10375414
• 关键词: 12 year old; Acoustics; Adult; Articulation; Auditory; Auditory system; Child; Childhood; Clinical; Clinical Trials Design; Cochlear Implants; Complex; Control Groups; Development; Distal; Double-Blind Method; Early Intervention; Electric Stimulation; Electrodes; Enrollment; Generations; Goals; Growth; Interdisciplinary Study; Intervention; Language; Language Disorders; Literature; Location; Measures; Mediating; Mediator of activation protein; Modeling; Monitor; Noise; Outcome; Participant; Patients; Procedures; Production; Psychophysics; Randomized; Randomized Controlled Clinical Trials; Reading; Regression Analysis; Research; Research Activity; Research Design; Resolution; Sampling; Short-Term Memory; Signal Transduction; Speech; Speech Disorders; Standardization; Technology; Testing; Time; Waiting Lists; aged; auditory deprivation; auditory processing; hearing impairment; image guided; implantation; improved; improved outcome; literacy; normal hearing; peer; phonological awareness; phonology; reading ability; reading comprehension; reading difficulties; signal processing; skills; speech recognition; temporal measurement

PROJECT SUMMARY Although the recent literature has indicated that children receiving cochlear implants (CIs) often have dramatically improved speech and language ability relative to previous generations of children with hearing loss, many pediatric CI recipients display persistent speech and language disorders despite early implantation and associated speech/language intervention. There is a striking paucity and ongoing need for studies that systematically examine the relationship between intracochlear electrode location, audiological profile, and subsequent phonological awareness, speech, language, and literacy in pediatric CI recipients. This project provides a unique opportunity to examine whether individualized, image-guided CI programming (IGCIP) significantly improves outcomes in pediatric CI patients. The proposed research activities will examine the impact of personalized IGCIP in pediatric CI recipients on measures of basic auditory function (spectral, temporal, and spectrotemporal resolution), word and non-word recognition, speech production, language, phonological awareness, and reading comprehension using a double blind, waitlist control randomized clinical trial (RCT) design. A total sample of 72 children with CIs aged six to twelve years old will be enrolled in the project: half (n = 36) will be randomized to an immediate IGCIP condition and half to a waitlist control condition. The waitlisted participants (n = 36) will undergo IGCIP after 12 months of monitoring and then followed for an additional 12 months after intervention (total time in the study for both groups: 24 months). Those immediately provided with IGCIP will also be followed for a total of 24 months. All participants will undergo extensive audiological assessment as well as tests of phonological awareness, speech, language, and literacy at baseline as well as at regular intervals: 2, 6, 12, 14, 18, and 24 months. We will use predictor analyses to determine the impact of immediate and deferred IGCIP on subsequent auditory, speech, language, and literacy outcomes.

项目总结 尽管最近的文献表明接受人工耳蜗术(CI)的儿童通常有 与前几代听力障碍儿童相比，他们的言语和语言能力显著提高 失血，许多儿童CI接受者尽管早期植入，但仍表现出持续的言语和语言障碍 以及相关的语音/语言干预。有一个惊人的缺乏和持续的需要的研究， 系统检查耳内电极位置、听力学特征和 儿童CI接受者随后的语音意识、言语、语言和识字。这个项目 提供了一个独特的机会来检查个性化的、图像引导的CI编程(IGCIP) 显著改善儿童脑梗塞患者的预后。拟议的研究活动将审查 个性化IGCIP对儿童脑梗塞患者基本听功能的影响(频谱， 时间和光谱时间分辨率)、单词和非单词识别、语音产生、语言 语音意识和阅读理解采用随机双盲、候补对照临床试验 试验(RCT)设计。共有72名6至12岁的身分证儿童参加 项目：一半(n=36)将随机进入IGCIP状态，另一半进入等待控制状态。 列入等待名单的参与者(n=36)在12个月的监测后将接受IGCIP，然后进行跟踪 干预后额外12个月(两组研究的总时间：24个月)。那些立即发生的 与IGCIP一起提供的项目也将在总共24个月内得到跟踪。所有参与者都将接受广泛的 听力评估以及语音意识、言语、语言和识字测试 基线以及定期间隔：2、6、12、14、18和24个月。我们将使用预测分析来 确定即时和延迟的IGCIP对随后的听觉、言语、语言和识字的影响 结果。