Promoting Diversity in Health-Related Research

促进健康相关研究的多样性

• 批准号: 10721795
• 负责人: Stephen Mark Camarata
• 金额: $ 2.79万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-11-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10721795
• 关键词: 12 year old; Audiology; Auditory; Child; Childhood; Cochlear Implants; Collaborations; Enrollment; Generations; Health; Intervention; Language; Language Disorders; Literature; Measures; Monitor; Operative Surgical Procedures; Outcome; Participant; Pathologist; Patients; Production; Randomized; Research; Research Activity; Speech; Speech Disorders; Time; Waiting Lists; aged; follow-up; hearing impairment; image guided; implantation; improved; improved outcome; literacy; parent project; pediatric patients; reading comprehension; speech recognition; temporal measurement; therapy design

ABSTRACT FROM PARENT PROJECT (Image Guided Programming: Pediatric Speech, Language and Literacy) Although the recent literature has indicated that children receiving cochlear implants often have dramatically improved speech and language ability relative to previous generations of children with hearing loss, many pediatric cochlear implant (CI) patients display persistent speech and language disorders despite early implantation and associated speech/language intervention [see (1,2)]. There is a striking paucity and ongoing need for studies that systematically examine the relationship between surgical implantation parameters, audiological profile, and subsequent speech, language, and literacy outcomes in pediatric CI [see (3)]. The proposed project provides a unique opportunity to examine whether individualized, image-guided CI programming (IGCIP) significantly improves outcomes in pediatric CI patients. The proposed research is a collaboration between an audiologist (Gifford) and a speech language pathologist (Camarata) and a biostatistician (Dietrich). The proposed research activities will examine the impact of personalized IGCIP in pediatric patients on measures of basic auditory function (spectral and temporal resolution), speech recognition, speech production, language, and measures of preliteracy and reading comprehension using a randomized wait-list control treatment design. A total of 60 children with CIs aged six to twelve years old will be enrolled in the project and one-half (n = 30) will be randomized to an immediate IGCIP condition and half to a 12 month waitlist control condition. The waitlisted participants (n = 30) will undergo IGCIP after 12 months of monitoring and followed up for an additional 12 months after the programming has been provided (total time in the study: 24 months). Those immediately provided with IGCIP will also be enrolled for a total of 24 months. All participants will undergo extensive audiological and speech and language assessments in addition to comprehensive audiological assessment at baseline as well as at regular intervals: 2, 6, 12, 14, 18, and 24 months. We will use predictor analyses to determine the impact of immediate and deferred IGCIP on subsequent auditory, speech, language, and literacy outcomes.

父母项目的摘要（图像指导编程：儿科语音， 语言和识字） 尽管最近的文献表明接受人工耳蜗的儿童经常有 相对于前几代儿童的语音和语言能力极大地提高了 由于听力损失，许多儿科人工耳蜗（CI）患者表现出持续的语音和 尽管早期植入和相关语音/语言干预，但语言障碍 [见（1,2）]。对研究有着显着的研究和持续的研究需求 手术植入参数，听力学特征和随后的关系之间的关系 小儿CI的语音，语言和识字结果[见（3）]。拟议的项目 提供了一个独特的机会来检查个性化的图像引导CI是否 编程（IGCIP）显着改善了小儿CI患者的预后。提议 研究是听力学家（Gifford）与语言病理学家之间的合作 （Camarata）和生物统计学家（Dietrich）。拟议的研究活动将研究 个性化IGCIP对儿科患者的影响对基本听觉功能的度量 （光谱和时间分辨率），语音识别，语音生产，语言和 使用随机等待列表控制 治疗设计。总共有60名独联体年龄六至十二岁的孩子将入学 该项目和一半（n = 30）将被随机分为立即的IGCIP条件，一半为 一个12个月的候补控制条件。等待名单的参与者（n = 30）将经历IGCIP 经过12个月的监视，然后在 提供了编程（研究中的总时间：24个月）。那些立即 IGCIP提供的还将总计24个月。所有参与者都会经历 除了全面之外，广泛的听力学和语言和语言评估 基线以及定期的听力学评估：2、6、12、14、18和24 月份。我们将使用预测分析来确定直接和递延的影响 IGCIP关于随后的听觉，语音，语言和识字结果。