CELLULAR AND MOLECULAR GEROSCIENCE CoBRE

细胞和分子老年科学 CoBRE

• 批准号: 10320855
• 负责人: William Edmund Sonntag
• 金额: $ 212.37万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10320855
• 关键词: Address; Advisory Committees; Age; Aging; Animal Model; Appointment; Award; Basic Science; Behavior assessment; Biomedical Research; Cells; Cities; Clinical Research; Clinical Trials; Collaborations; Degenerative polyarthritis; Disease; Ensure; Environment; Etiology; Event; Faculty; Failure; Fostering; Foundations; Functional disorder; Funding; Generations; Geroscience; Goals; Grant; Growth; Health Sciences; Heart Diseases; Hormonal; Impaired cognition; Infrastructure; Institution; Interdisciplinary Study; International; Intervention; Investments; Knowledge; Leadership; Literature; Longevity; Malignant Neoplasms; Medical Research; Medical center; Mentors; Mitotic; Molecular; Molecular Analysis; Oklahoma; Organism; Outcome; Participant; Phase; Phenotype; Prevalence; Process; Program Development; Research; Research Personnel; Research Project Grants; Research Support; Scientist; Services; Stroke; Structure; Training; Translational Research; United States National Institutes of Health; Universities; Work; age related; base; career development; cellular imaging; disorder risk; expectation; experience; healthspan; human disease; improved; innovation; inter-institutional; multidisciplinary; next generation; novel; pre-clinical research; prevent; programs; recruit; statistics; success

There have been impressive advances in understanding the molecular and cellular mechanisms of aging, including the discovery of manipulations that delay aging and increase healthspan. Importantly, these interventions also reduce or prevent age-related diseases. These outcomes raise the possibility that multiple human diseases arise from a common cause – aging. The premise of this CoBRE Phase 1 is that the mechanisms of aging and the mechanisms of age-related diseases share common cellular and molecular processes that underlie healthspan and lifespan. An important corollary to this concept is that pre-clinical and clinical research on age-related diseases must incorporate an understanding of the cellular/molecular changes that occur with age in order to adequately develop treatments for age-related diseases. Here, we propose a multidisciplinary, inter-departmental, and inter-institutional CoBRE program focused on Cellular and Molecular Geroscience. Geroscience is a new, interdisciplinary scientific field that addresses the cellular and molecular events that dramatically increase the risk for disease with age, create a ‘permissive milieu’ and, as a result, disease increases exponentially. Our program has exceptional institutional support. The program is highly innovative in that it combines mentoring of promising junior investigators (PJIs) by outstanding scientific experts who are currently studying mechanisms of aging and by faculty investigating age-related disease in a manner that will increase both the quantity and quality of on-going disease-related research in the context of the aging organism. These goals will be accomplished through the mentoring of PJIs, who have faculty appointments at OUHSC; recruiting senior investigators to the OUHSC campus; and developing the necessary infrastructure for support of the research program. The specific aims for the program are: 1. Develop and expand institutional biomedical research in Geroscience through the mentoring of PJIs by highly experienced, dedicated senior investigators. 2. Enhance the infrastructure critical for expanding Geroscience research in Oklahoma. 3. Foster collegial and collaborative relationships between CoBRE investigators and other scientists. 4. Establish milestones and expectations that ensure the success of the program and its participants. The outcome will be a sustainable, interdisciplinary research structure on the OUHSC campus, which will produce a new generation of collaborative Geroscience-trained researchers and establish OUHSC as a leader in Geroscience.

在了解衰老的分子和细胞机制方面取得了令人印象深刻的进展， 包括发现了延缓衰老和延长健康寿命的手法。重要的是，这些 干预措施还可以减少或预防与年龄有关的疾病。这些结果增加了一种可能性，即 人类疾病是由一个共同的原因引起的--衰老。Cobre第一阶段的前提是 衰老机制和衰老相关疾病的机制具有共同的细胞和分子机制 健康寿命和寿命的基础过程。这一概念的一个重要推论是，临床前和 对年龄相关疾病的临床研究必须包含对细胞/分子变化的了解。 为了充分开发与年龄相关的疾病的治疗方法，随着年龄的增长而发生的变化。在这里，我们提出一种 以细胞和分子为重点的多学科、跨部门和跨机构的COBRE计划 老年学。老年学是一个新的、跨学科的科学领域，它研究细胞和分子 这些事件会随着年龄的增长而显著增加患病的风险，创造出一种“宽松的环境”，因此， 疾病呈指数增长。我们的项目有特殊的机构支持。该计划具有高度的 创新之处在于它结合了杰出科学专家对有前途的初级调查人员(PJI)的指导 他们目前正在研究衰老的机制，并由教员以一种方式研究与年龄相关的疾病 这将提高老龄化背景下正在进行的与疾病相关的研究的数量和质量 有机体。这些目标将通过PJI的指导来实现，PJI的教职员工任命在 OUHSC；招募高级调查人员到OUHSC校园；并开发必要的基础设施 支持该研究计划。该计划的具体目标是：1.发展和扩大机构 通过由经验丰富、敬业的老年人指导PJI进行老年科学中的生物医学研究 调查人员。2.加强对扩大俄克拉荷马州老年科学研究至关重要的基础设施。3.寄养家庭 科布雷研究人员和其他科学家之间的合作和合作关系。4.建立 确保项目及其参与者成功的里程碑和期望。结果将是 OUHSC校园的可持续、跨学科研究结构，这将产生新一代 建立协作的老年科学培训研究人员，并将OUHSC确立为老年科学领域的领导者。