GEROSCIENCE TRAINING PROGRAM IN OKLAHOMA

摘要 这个应用程序是一个应用程序的修订，要求5年的跨学科的资金 为3名博士前研究生和4名博士后研究员提供关于衰老生物学的培训。拟议 该计划建立在7个学术/研究项目和三个（3） 机构，俄克拉荷马州大学健康科学中心（OUHSC），俄克拉荷马州医学研究 基金会（OMRF）和俄克拉荷马州市VA医疗中心。随着老年人数量的增加， 个人在美国和世界上，拟议的计划已经建立，以解决 对具有衰老生物学专业知识的研究人员的前所未有的需求，这些研究人员经过培训， 衰老和年龄相关疾病研究的复杂性。OUHSC，OMRF和VA致力于 广泛的资源，以发展老龄化计划，并在过去7年，和研究人员从 这些项目已获得超过8300万美元的研究/基础设施支持，并发表了200多篇论文。 同行评审的手稿这项投资导致最近成功提交了一份内森 2015年7月获得资助的休克卓越中心。该计划的主要目标是准备 研究生和博士后研究员的职业生涯作为领导者在新兴领域的 老年科学我们的目标是为未来的科学家提供严格，优秀，创新的培训， 进入老龄化研究的特定学科。该计划由15名教师组成， OUHSC/OMRF/VA校园，并捕捉激烈的合作，热情和独特的资源 老年人社区。该计划还得到了OUHSC的特殊承诺的支持， OMRF，唐纳德W。雷诺兹基金会和许多项目和核心， 每个机构的支持。为该计划选择的学员将根据以下因素进行竞争性选择： 学术卓越和他们的兴趣和动机的职业生涯中老化研究。的主要活动 受训人员将开发和完成与衰老和/或与年龄有关的疾病有关的研究项目 利用基因组学、蛋白质组学、表观遗传学、细胞生物学、生物化学和 physiology.由于我们的教师之间的密切合作，学员将被要求有一个 初级和次级导师，以确保最高质量的培训和专注于老龄化研究。的 学员还将受益于我们的老年科学课程，临床经验，研讨会计划，期刊 由老龄化领域的知名领导人教授/监督的俱乐部和务虚会。最后，学员 将得到指导，以发展适当的演讲和赠款写作技能，并将被要求提交 一份独立的F系列拨款申请总之，本培训计划旨在帮助特殊 年轻的科学家发展知识，技术，写作和表达能力所需的生产力 作为独立的研究人员和教育工作者在老龄化研究的职业生涯。 !

ABSTRACT This application is a revision of an application requesting 5 years of funding for an interdisciplinary training on the biology of aging for 3 pre-doctoral students and 4 post-doctoral fellows. The proposed program builds on the rapidly expanding expertise of 7 academic/research programs and three (3) institutions, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma Medical Research Foundation (OMRF) and the Oklahoma City VA Medical Center. With the increased number of older individuals in the United States and the world, the proposed program has been created to address the unprecedented demand for researchers with expertise in the biology of aging that are trained to address the complex nature of research on aging and age-related diseases. OUHSC, OMRF and the VA have devoted extensive resources to the development of aging programs and in the past 7 years, and researchers from these programs have been awarded over $83M in research/infrastructure support and published over 200 peer-reviewed manuscripts. This investment resulted in the recent successful submission of a Nathan Shock Center of Excellence that was funded in July 2015. The primary goal of this program is to prepare graduate students and post-doctoral fellows for careers as leaders in the emerging field of Geroscience. Our goal is to provide rigorous, outstanding, innovative training for future scientists that are entering specific disciplines in aging research. The program is composed of 15 faculty members from the OUHSC/OMRF/VA campus and captures the intense collaborations, enthusiasm and the unique resources of the aging community. The program is also supported by exceptional commitment from OUHSC and OMRF, the Donald W. Reynolds Foundation and numerous programs and cores that are continuously supported by each institution. Trainees selected for this program will be chosen competitively based on academic excellence and their interest and motivation for careers in aging research. The primary activity of the trainees will be to develop and complete research projects relevant to aging and/or age-related disease using state-of-the-art technologies in genomics, proteomics, epigenetics, cell biology, biochemistry and physiology. Because of the close collaborations among our faculty, trainees will be required to have a primary and secondary mentor to ensure the highest quality of training and focus on aging research. The trainees will also benefit from our Geroscience courses, clinical experiences, seminar programs, journal clubs and retreats that are taught/overseen by well-established leaders in the field of aging. Finally trainees will be mentored to develop appropriate presentation and grant writing skills and will be required to submit an independent F-series grant proposal. In summary, this training program is designed to help exceptional young scientists develop the intellectual, technical, writing and presentation skills needed for productive careers as independent investigators and educators in aging research. !