GEROSCIENCE TRAINING PROGRAM IN OKLAHOMA

摘要 这份申请是对一份申请的修订，该申请要求为跨学科的 对3名博士后学员和4名博士后研究员进行衰老生物学培训。建议数 该计划建立在7个学术/研究计划和3(3)个快速扩展的专业知识的基础上 俄克拉荷马大学健康科学中心(OUHSC)，俄克拉荷马医学研究机构 基金会(OMRF)和俄克拉何马城退伍军人医疗中心。随着老年人数量的增加 美国和世界上的个人，拟议的计划是为了解决 对具有衰老生物学专业知识的研究人员的需求前所未有，他们受到的培训是为了解决 老龄化和与年龄相关的疾病研究的复杂性。OUHSC、OMRF和退伍军人管理局已经致力于 在过去的7年里，为发展老龄化计划提供了广泛的资源，来自 这些项目已经获得了超过8300万美元的研究/基础设施支持，并出版了200多份 同行评议的手稿。这项投资导致最近成功提交了一份内森 震撼卓越中心，于2015年7月获得资助。这个项目的主要目标是准备 作为新兴领域的领导者的研究生和博士后研究员 老年学。我们的目标是为未来的科学家提供严谨、杰出、创新的培训 进入老龄化研究的特定学科。该项目由15名教职员工组成 OHSC/OMRF/VA园区，捕捉到了激烈的合作、热情和独特的资源 老龄化社区的一部分。该计划还得到了OUHSC和OHSC的特殊承诺的支持 OMRF、唐纳德·W·雷诺兹基金会和许多计划和核心 由每个机构提供支持。被选中参加此项目的受训人员将根据以下条件进行竞争性选择 学术成就和他们对老龄化研究事业的兴趣和动力。的主要活动 受训人员将开发和完成与老龄化和/或年龄相关疾病相关的研究项目 在基因组学、蛋白质组学、表观遗传学、细胞生物学、生物化学和 生理学。由于我们教职员工的密切合作，实习生将被要求拥有 主辅导师确保最高质量的培训，专注于老龄化研究。这个 学员还将受益于我们的老年科学课程、临床经验、研讨会计划、期刊 由老龄化领域的知名领导者授课/监督的俱乐部和务虚会。最终受训人员 将被指导发展适当的演讲和写作技能，并将被要求提交 一份独立的F系列拨款提案。总而言之，本培训计划旨在帮助卓越的 青年科学家开发智力、技术、写作和演示技能，以提高生产率 在老龄化研究中作为独立调查人员和教育工作者的职业。 好了！

ABSTRACT This application is a revision of an application requesting 5 years of funding for an interdisciplinary training on the biology of aging for 3 pre-doctoral students and 4 post-doctoral fellows. The proposed program builds on the rapidly expanding expertise of 7 academic/research programs and three (3) institutions, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma Medical Research Foundation (OMRF) and the Oklahoma City VA Medical Center. With the increased number of older individuals in the United States and the world, the proposed program has been created to address the unprecedented demand for researchers with expertise in the biology of aging that are trained to address the complex nature of research on aging and age-related diseases. OUHSC, OMRF and the VA have devoted extensive resources to the development of aging programs and in the past 7 years, and researchers from these programs have been awarded over $83M in research/infrastructure support and published over 200 peer-reviewed manuscripts. This investment resulted in the recent successful submission of a Nathan Shock Center of Excellence that was funded in July 2015. The primary goal of this program is to prepare graduate students and post-doctoral fellows for careers as leaders in the emerging field of Geroscience. Our goal is to provide rigorous, outstanding, innovative training for future scientists that are entering specific disciplines in aging research. The program is composed of 15 faculty members from the OUHSC/OMRF/VA campus and captures the intense collaborations, enthusiasm and the unique resources of the aging community. The program is also supported by exceptional commitment from OUHSC and OMRF, the Donald W. Reynolds Foundation and numerous programs and cores that are continuously supported by each institution. Trainees selected for this program will be chosen competitively based on academic excellence and their interest and motivation for careers in aging research. The primary activity of the trainees will be to develop and complete research projects relevant to aging and/or age-related disease using state-of-the-art technologies in genomics, proteomics, epigenetics, cell biology, biochemistry and physiology. Because of the close collaborations among our faculty, trainees will be required to have a primary and secondary mentor to ensure the highest quality of training and focus on aging research. The trainees will also benefit from our Geroscience courses, clinical experiences, seminar programs, journal clubs and retreats that are taught/overseen by well-established leaders in the field of aging. Finally trainees will be mentored to develop appropriate presentation and grant writing skills and will be required to submit an independent F-series grant proposal. In summary, this training program is designed to help exceptional young scientists develop the intellectual, technical, writing and presentation skills needed for productive careers as independent investigators and educators in aging research. !