GEROSCIENCE TRAINING PROGRAM IN OKLAHOMA

摘要 该申请是对跨学科项目请求 5 年资助的申请的修订。 为 3 名博士前学生和 4 名博士后进行衰老生物学培训。拟议的 该计划建立在 7 个学术/研究计划和三 (3) 个快速扩展的专业知识之上 机构、俄克拉荷马大学健康科学中心 (OUHSC)、俄克拉荷马医学研究中心 基金会 (OMRF) 和俄克拉荷马城退伍军人管理局医疗中心。随着老年人数量的增加 美国和世界各地的个人，拟议的计划是为了解决 对具有衰老生物学专业知识的研究人员有着前所未有的需求，这些研究人员接受过培训来解决这一问题 衰老和年龄相关疾病研究的复杂性。 OUHSC、OMRF 和 VA 致力于 在过去的 7 年里，我们为老龄化项目的发展提供了广泛的资源，并且来自 这些项目已获得超过 8300 万美元的研究/基础设施支持，并发表了 200 多篇文章 同行评审的手稿。这项投资导致最近成功提交了一份 Nathan 休克卓越中心于 2015 年 7 月资助。该计划的主要目标是准备 研究生和博士后研究员作为新兴领域的领导者 老年科学。我们的目标是为未来的科学家提供严格、杰出、创新的培训 进入衰老研究的特定学科。该计划由来自该学院的 15 名教职人员组成 OUHSC/OMRF/VA 校园并拥有密切的合作、热情和独特的资源 属于老龄化社会。该计划还得到了 OUHSC 和 OMRF、Donald W. Reynolds 基金会以及众多持续不断的项目和核心 得到各机构的支持。入选该计划的学员将根据以下条件进行竞争性选拔： 学术成就以及他们对衰老研究职业的兴趣和动力。主要活动 学员将开发并完成与衰老和/或与年龄相关的疾病相关的研究项目 使用基因组学、蛋白质组学、表观遗传学、细胞生物学、生物化学和 生理学。由于我们的教师之间的密切合作，学员将被要求拥有 小学和中学导师，确保最高质量的培训并专注于老龄化研究。的 学员还将受益于我们的老年科学课程、临床经验、研讨会项目、期刊 由老龄化领域知名领导者教授/监督的俱乐部和静修中心。最后是练习生 将接受指导以培养适当的演讲和资助写作技巧，并需要提交 独立的 F 系列拨款提案。总之，该培训计划旨在帮助特殊的 年轻科学家培养生产力所需的智力、技术、写作和表达技能 作为衰老研究的独立调查员和教育者。 ！

ABSTRACT This application is a revision of an application requesting 5 years of funding for an interdisciplinary training on the biology of aging for 3 pre-doctoral students and 4 post-doctoral fellows. The proposed program builds on the rapidly expanding expertise of 7 academic/research programs and three (3) institutions, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma Medical Research Foundation (OMRF) and the Oklahoma City VA Medical Center. With the increased number of older individuals in the United States and the world, the proposed program has been created to address the unprecedented demand for researchers with expertise in the biology of aging that are trained to address the complex nature of research on aging and age-related diseases. OUHSC, OMRF and the VA have devoted extensive resources to the development of aging programs and in the past 7 years, and researchers from these programs have been awarded over $83M in research/infrastructure support and published over 200 peer-reviewed manuscripts. This investment resulted in the recent successful submission of a Nathan Shock Center of Excellence that was funded in July 2015. The primary goal of this program is to prepare graduate students and post-doctoral fellows for careers as leaders in the emerging field of Geroscience. Our goal is to provide rigorous, outstanding, innovative training for future scientists that are entering specific disciplines in aging research. The program is composed of 15 faculty members from the OUHSC/OMRF/VA campus and captures the intense collaborations, enthusiasm and the unique resources of the aging community. The program is also supported by exceptional commitment from OUHSC and OMRF, the Donald W. Reynolds Foundation and numerous programs and cores that are continuously supported by each institution. Trainees selected for this program will be chosen competitively based on academic excellence and their interest and motivation for careers in aging research. The primary activity of the trainees will be to develop and complete research projects relevant to aging and/or age-related disease using state-of-the-art technologies in genomics, proteomics, epigenetics, cell biology, biochemistry and physiology. Because of the close collaborations among our faculty, trainees will be required to have a primary and secondary mentor to ensure the highest quality of training and focus on aging research. The trainees will also benefit from our Geroscience courses, clinical experiences, seminar programs, journal clubs and retreats that are taught/overseen by well-established leaders in the field of aging. Finally trainees will be mentored to develop appropriate presentation and grant writing skills and will be required to submit an independent F-series grant proposal. In summary, this training program is designed to help exceptional young scientists develop the intellectual, technical, writing and presentation skills needed for productive careers as independent investigators and educators in aging research. !