CELLULAR AND MOLECULAR GEROSCIENCE CoBRE

细胞和分子老年科学 CoBRE

• 批准号: 10536644
• 负责人: William Edmund Sonntag
• 金额: $ 210.69万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10536644
• 关键词: Address; Advisory Committees; Age; Aging; Animal Model; Appointment; Award; Basic Science; Behavior assessment; Biomedical Research; Cells; Cities; Clinical Research; Clinical Trials; Collaborations; Dedications; Degenerative polyarthritis; Disease; Ensure; Environment; Etiology; Event; Faculty; Failure; Fostering; Foundations; Functional disorder; Funding; Generations; Geroscience; Goals; Grant; Growth; Health Sciences; Heart Diseases; Hormonal; Impaired cognition; Infrastructure; Institution; Interdisciplinary Study; International; Intervention; Investments; Knowledge; Leadership; Literature; Longevity; Malignant Neoplasms; Medical Research; Medical center; Mentors; Molecular; Molecular Analysis; Oklahoma; Organism; Outcome; Participant; Phase; Phenotype; Prevalence; Process; Productivity; Program Development; Research; Research Personnel; Research Project Grants; Research Support; Scientist; Services; Stroke; Structure; Training; Translational Research; United States National Institutes of Health; Universities; Work; age related; career development; cellular imaging; disorder risk; expectation; experience; healthspan; human disease; improved; innovation; inter-institutional; multidisciplinary; next generation; novel; permissiveness; postmitotic; pre-clinical research; prevent; programs; recruit; statistics; success

There have been impressive advances in understanding the molecular and cellular mechanisms of aging, including the discovery of manipulations that delay aging and increase healthspan. Importantly, these interventions also reduce or prevent age-related diseases. These outcomes raise the possibility that multiple human diseases arise from a common cause – aging. The premise of this CoBRE Phase 1 is that the mechanisms of aging and the mechanisms of age-related diseases share common cellular and molecular processes that underlie healthspan and lifespan. An important corollary to this concept is that pre-clinical and clinical research on age-related diseases must incorporate an understanding of the cellular/molecular changes that occur with age in order to adequately develop treatments for age-related diseases. Here, we propose a multidisciplinary, inter-departmental, and inter-institutional CoBRE program focused on Cellular and Molecular Geroscience. Geroscience is a new, interdisciplinary scientific field that addresses the cellular and molecular events that dramatically increase the risk for disease with age, create a ‘permissive milieu’ and, as a result, disease increases exponentially. Our program has exceptional institutional support. The program is highly innovative in that it combines mentoring of promising junior investigators (PJIs) by outstanding scientific experts who are currently studying mechanisms of aging and by faculty investigating age-related disease in a manner that will increase both the quantity and quality of on-going disease-related research in the context of the aging organism. These goals will be accomplished through the mentoring of PJIs, who have faculty appointments at OUHSC; recruiting senior investigators to the OUHSC campus; and developing the necessary infrastructure for support of the research program. The specific aims for the program are: 1. Develop and expand institutional biomedical research in Geroscience through the mentoring of PJIs by highly experienced, dedicated senior investigators. 2. Enhance the infrastructure critical for expanding Geroscience research in Oklahoma. 3. Foster collegial and collaborative relationships between CoBRE investigators and other scientists. 4. Establish milestones and expectations that ensure the success of the program and its participants. The outcome will be a sustainable, interdisciplinary research structure on the OUHSC campus, which will produce a new generation of collaborative Geroscience-trained researchers and establish OUHSC as a leader in Geroscience.

在理解衰老的分子和细胞机制方面已经取得了令人印象深刻的进展， 包括发现延缓衰老和增加健康寿命的方法。重要的是这些 干预措施还可减少或预防与年龄有关的疾病。这些结果提高了多个 人类疾病的产生有一个共同的原因-老化。这个CoBRE第一阶段的前提是， 衰老的机制和与年龄相关的疾病的机制有着共同的细胞和分子机制， 健康和寿命的基础过程。这一概念的一个重要推论是， 年龄相关疾病的临床研究必须包括对细胞/分子变化的理解， 以充分开发与年龄有关的疾病的治疗方法。在这里，我们提出一个 多学科、跨部门和跨机构的CoBRE计划，重点关注细胞和分子 老年科学老年科学是一个新的，跨学科的科学领域，解决细胞和分子 随着年龄的增长，疾病风险急剧增加的事件，创造了一个“宽容的环境”，因此， 疾病呈指数增长。我们的计划有特殊的机构支持。该方案高度 创新之处在于它结合了杰出科学专家对有前途的初级研究人员（PJIs）的指导 他们目前正在研究衰老的机制， 这将提高正在进行的老龄化背景下的疾病相关研究的数量和质量 有机体这些目标将通过PJIs的指导来实现，PJIs在 OUHSC;招募高级调查员到OUHSC校园;并发展必要的基础设施， 研究计划的支持。该计划的具体目标是：1。发展和扩大机构 通过由经验丰富，敬业的高级PJIs的指导，在老年科学的生物医学研究 investigators. 2.加强基础设施的关键扩大老年科学研究在俄克拉荷马州。3.福斯特 CoBRE研究人员和其他科学家之间的学院和合作关系。4.建立 里程碑和期望，以确保该计划及其参与者的成功。结果会 一个可持续的，跨学科的研究结构在OUHSC校园，这将产生新一代 合作老年科学培训的研究人员，并建立OUHSC作为老年科学的领导者。