CELLULAR AND MOLECULAR GEROSCIENCE CoBRE

细胞和分子老年科学 CoBRE

• 批准号: 10536644
• 负责人: William Edmund Sonntag
• 金额: $ 210.69万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10536644
• 关键词: Address; Advisory Committees; Age; Aging; Animal Model; Appointment; Award; Basic Science; Behavior assessment; Biomedical Research; Cells; Cities; Clinical Research; Clinical Trials; Collaborations; Dedications; Degenerative polyarthritis; Disease; Ensure; Environment; Etiology; Event; Faculty; Failure; Fostering; Foundations; Functional disorder; Funding; Generations; Geroscience; Goals; Grant; Growth; Health Sciences; Heart Diseases; Hormonal; Impaired cognition; Infrastructure; Institution; Interdisciplinary Study; International; Intervention; Investments; Knowledge; Leadership; Literature; Longevity; Malignant Neoplasms; Medical Research; Medical center; Mentors; Molecular; Molecular Analysis; Oklahoma; Organism; Outcome; Participant; Phase; Phenotype; Prevalence; Process; Productivity; Program Development; Research; Research Personnel; Research Project Grants; Research Support; Scientist; Services; Stroke; Structure; Training; Translational Research; United States National Institutes of Health; Universities; Work; age related; career development; cellular imaging; disorder risk; expectation; experience; healthspan; human disease; improved; innovation; inter-institutional; multidisciplinary; next generation; novel; permissiveness; postmitotic; pre-clinical research; prevent; programs; recruit; statistics; success

There have been impressive advances in understanding the molecular and cellular mechanisms of aging, including the discovery of manipulations that delay aging and increase healthspan. Importantly, these interventions also reduce or prevent age-related diseases. These outcomes raise the possibility that multiple human diseases arise from a common cause – aging. The premise of this CoBRE Phase 1 is that the mechanisms of aging and the mechanisms of age-related diseases share common cellular and molecular processes that underlie healthspan and lifespan. An important corollary to this concept is that pre-clinical and clinical research on age-related diseases must incorporate an understanding of the cellular/molecular changes that occur with age in order to adequately develop treatments for age-related diseases. Here, we propose a multidisciplinary, inter-departmental, and inter-institutional CoBRE program focused on Cellular and Molecular Geroscience. Geroscience is a new, interdisciplinary scientific field that addresses the cellular and molecular events that dramatically increase the risk for disease with age, create a ‘permissive milieu’ and, as a result, disease increases exponentially. Our program has exceptional institutional support. The program is highly innovative in that it combines mentoring of promising junior investigators (PJIs) by outstanding scientific experts who are currently studying mechanisms of aging and by faculty investigating age-related disease in a manner that will increase both the quantity and quality of on-going disease-related research in the context of the aging organism. These goals will be accomplished through the mentoring of PJIs, who have faculty appointments at OUHSC; recruiting senior investigators to the OUHSC campus; and developing the necessary infrastructure for support of the research program. The specific aims for the program are: 1. Develop and expand institutional biomedical research in Geroscience through the mentoring of PJIs by highly experienced, dedicated senior investigators. 2. Enhance the infrastructure critical for expanding Geroscience research in Oklahoma. 3. Foster collegial and collaborative relationships between CoBRE investigators and other scientists. 4. Establish milestones and expectations that ensure the success of the program and its participants. The outcome will be a sustainable, interdisciplinary research structure on the OUHSC campus, which will produce a new generation of collaborative Geroscience-trained researchers and establish OUHSC as a leader in Geroscience.

在了解衰老的分子和细胞机制方面已经取得了令人印象深刻的进展，