CELLULAR AND MOLECULAR GEROSCIENCE CoBRE

细胞和分子老年科学 CoBRE

• 批准号: 10598397
• 负责人: William Edmund Sonntag
• 金额: $ 25万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-02 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10598397
• 关键词: Address; Age; Aging; Appointment; Biomedical Research; Cells; Chromium; Clinical Research; Disease; Disease Progression; Doctor of Philosophy; Ensure; Event; Faculty; Fostering; Geroscience; Goals; Infrastructure; Intervention; Longevity; Mentors; Molecular; Oklahoma; Onset of illness; Organism; Outcome; Participant; Phase; Prevalence; Process; Research; Research Personnel; Research Support; Scientist; Technology; age related; design; disorder risk; expectation; experience; healthspan; human disease; innovation; inter-institutional; multidisciplinary; next generation; pre-clinical research; prevent; programs; recruit; success

Sonntag, William E., PhD P20GM125528 ABSTRACT There have been impressive advances in understanding the molecular and cellular mechanisms of aging, including the discovery of manipulations that delay aging and increase healthspan. Importantly, these interventions also reduce or prevent age-related diseases. These outcomes raise the possibility that multiple human diseases arise from a common cause – aging. The premise of this CoBRE Phase 1 is that the mechanisms of aging and the mechanisms of age-related diseases share common cellular and molecular processes that underlie healthspan and lifespan. An important corollary to this concept is that pre-clinical and clinical research on age-related diseases must incorporate an understanding of the cellular/molecular changes that occur with age in order to adequately develop treatments for age-related diseases. Here, we propose a multidisciplinary, inter-departmental, and inter-institutional CoBRE program focused on Cellular and Molecular Geroscience. Geroscience is a relatively new, interdisciplinary scientific field that addresses the cellular and molecular events that dramatically increase the risk for disease with age, create a ‘permissive milieu’ and, as a result, disease increases exponentially. Our program has exceptional institutional support. The program is highly innovative in that it combines mentoring of promising junior investigators (PJIs) by outstanding scientific experts who are currently studying mechanisms of aging and by faculty investigating age- related disease in a manner that will increase both the quantity and quality of on-going disease-related research in the context of the aging organism. These goals will be accomplished through the mentoring of PJIs, who have faculty appointments at OUHSC; recruiting senior investigators to the OUHSC campus; and developing the necessary infrastructure for support of the research program. The specific aims for the program are: 1. Develop and expand institutional biomedical research in Geroscience through the mentoring of PJIs by highly experienced, dedicated senior investigators. 2. Enhance the infrastructure critical for expanding Geroscience research in Oklahoma. 3. Foster collegial and collaborative relationships between CoBRE investigators and other scientists. 4. Establish milestones and expectations that ensure the success of the program and its participants. This supplement is designed to advance our research into single cell transciptomics using Chromium and Chromium Connect technology.

Sonntag，William E.，博士 P20GM125528 抽象的 在理解衰老的分子和细胞机制方面取得了令人印象深刻的进步， 包括发现延迟衰老并增加健康范围的操作。重要的是，这些 干预措施还减少或预防与年龄有关的疾病。这些结果增加了多个的可能性 人类疾病源于一个共同的原因 - 衰老。该毛线第1阶段的前提是 衰老的机制和与年龄相关疾病的机制共享常见的细胞和分子 基于HealthSpan和寿命的过程。这个概念的重要推论是临床前和 关于年龄相关疾病的临床研究必须纳入对细胞/分子变化的理解 随着年龄的增长，这是为了充分发展与年龄相关疾病的治疗方法。在这里，我们建议 多学科，部门间和机构间的鞋底计划，重点是细胞和 分子果仁科学。 Geroscience是一个相对新的，跨学科的科学领域，可解决 细胞和分子事件会大大增加随着年龄的增长的风险，创建宽容性 环境，结果，疾病呈指数增长。我们的计划具有出色的机构支持。 该计划具有很高的创新性，因为它结合了有前途的初级研究人员（PJIS）的心理 目前正在研究衰老机制的杰出科学专家，并通过调查年龄的教师 相关疾病的方式将增加与疾病有关的研究的数量和质量 在老化组织的背景下。这些目标将通过PJIS的心理来实现 在OUHSC任职；招募高级调查员到OUHSC校园；并发展 支持研究计划的必要基础设施。该程序的具体目的是：1。 通过高度对PJI的心理发展，开发和扩展Gerosciencion的制度生物医学研究 经验丰富的高级调查员。 2。增强基础设施对于扩展Geroscience至关重要 俄克拉荷马州的研究。 3。培养山核桃研究人员与协作关系 其他科学家。 4.建立里程碑和期望，以确保该计划的成功及 参与者。该补充旨在使用我们对单细胞跨椎间盘学的研究 铬和铬连接技术。