CELLULAR AND MOLECULAR GEROSCIENCE CoBRE

威廉·E·桑塔格，博士 P20GM125528 摘要 在了解衰老的分子和细胞机制方面取得了令人印象深刻的进展， 包括发现了延缓衰老和延长健康寿命的手法。重要的是，这些 干预措施还可以减少或预防与年龄有关的疾病。这些结果增加了一种可能性，即 人类疾病是由一个共同的原因引起的--衰老。Cobre第一阶段的前提是 衰老机制和衰老相关疾病的机制具有共同的细胞和分子机制 健康寿命和寿命的基础过程。这一概念的一个重要推论是，临床前和 对年龄相关疾病的临床研究必须包含对细胞/分子变化的了解。 为了充分开发与年龄相关的疾病的治疗方法，随着年龄的增长而发生的变化。在这里，我们提出一种 多学科、跨部门和跨机构的Cobre计划，专注于蜂窝和 分子老年学。老年学是一个相对较新的、跨学科的科学领域，它研究 随着年龄的增长，细胞和分子事件会显著增加患病风险，从而导致 因此，疾病呈指数级增长。我们的项目有特殊的机构支持。 该计划具有很高的创新性，因为它结合了对有前途的初级调查人员(PJI)的指导，通过 目前正在研究衰老机制的杰出科学专家和研究年龄的教职员工- 将提高正在进行的与疾病有关的研究的数量和质量 在老化有机体的背景下。这些目标将通过PJI的指导实现，世界卫生组织 在OUHSC任命教员；向OUHSC校园招聘高级调查人员；以及开发 支持研究计划所需的基础设施。该计划的具体目标是：1. 通过对PJI的指导，发展和扩大老年科学方面的机构生物医学研究 经验丰富、敬业的高级调查员。2.加强对发展老年科学至关重要的基础设施 俄克拉何马州的研究。3.促进Cobre调查人员和 其他科学家。4.建立里程碑和期望，以确保该计划及其 参与者。本补充资料旨在推进我们对单细胞横切术的研究。 铬和铬连接技术。

Sonntag, William E., PhD P20GM125528 ABSTRACT There have been impressive advances in understanding the molecular and cellular mechanisms of aging, including the discovery of manipulations that delay aging and increase healthspan. Importantly, these interventions also reduce or prevent age-related diseases. These outcomes raise the possibility that multiple human diseases arise from a common cause – aging. The premise of this CoBRE Phase 1 is that the mechanisms of aging and the mechanisms of age-related diseases share common cellular and molecular processes that underlie healthspan and lifespan. An important corollary to this concept is that pre-clinical and clinical research on age-related diseases must incorporate an understanding of the cellular/molecular changes that occur with age in order to adequately develop treatments for age-related diseases. Here, we propose a multidisciplinary, inter-departmental, and inter-institutional CoBRE program focused on Cellular and Molecular Geroscience. Geroscience is a relatively new, interdisciplinary scientific field that addresses the cellular and molecular events that dramatically increase the risk for disease with age, create a ‘permissive milieu’ and, as a result, disease increases exponentially. Our program has exceptional institutional support. The program is highly innovative in that it combines mentoring of promising junior investigators (PJIs) by outstanding scientific experts who are currently studying mechanisms of aging and by faculty investigating age- related disease in a manner that will increase both the quantity and quality of on-going disease-related research in the context of the aging organism. These goals will be accomplished through the mentoring of PJIs, who have faculty appointments at OUHSC; recruiting senior investigators to the OUHSC campus; and developing the necessary infrastructure for support of the research program. The specific aims for the program are: 1. Develop and expand institutional biomedical research in Geroscience through the mentoring of PJIs by highly experienced, dedicated senior investigators. 2. Enhance the infrastructure critical for expanding Geroscience research in Oklahoma. 3. Foster collegial and collaborative relationships between CoBRE investigators and other scientists. 4. Establish milestones and expectations that ensure the success of the program and its participants. This supplement is designed to advance our research into single cell transciptomics using Chromium and Chromium Connect technology.