Intervertebral Disc Mechanics with Functional GRASP-MRI

具有功能性 GRASP-MRI 的椎间盘力学

• 批准号: 10328260
• 负责人: Ravinder Regatte
• 金额: $ 18.46万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10328260
• 关键词: Address; Affect; Age; Aging; Algorithms; Anatomy; Animals; Back Pain; Behavior; Biochemical; Cadaver; Cattle; Characteristics; Chronic; Clinical; Complex; Data; Deformity; Diagnosis; Diffusion; Evaluation; Gender; Goals; Histology; Human; Image; Imaging Techniques; Individual; Intervertebral disc structure; Lead; Life Style; Low Back Pain; Low Prevalence; Magnetic Resonance Imaging; Measurement; Mechanics; Modeling; Motion; Noise; Opioid; Optics; Pain; Pathology; Performance; Posture; Prevalence; Property; Proteoglycan; Protocols documentation; Radial; Recovery; Relaxation; Reporting; Reproducibility; Resolution; Rest; Sampling; Scanning; Silicone Gels; Source; Spinal; Spinal Stenosis; Spine surgery; Spondylolisthesis; Supination; Symptoms; T2 weighted imaging; Techniques; Testing; Time; Translations; Validation; Vertebral column; base; biomechanical test; discogenic pain; flexibility; functional disability; global health; healthy volunteer; imaging study; in vivo; in vivo evaluation; intervertebral disk degeneration; mechanical load; non-invasive imaging; normal aging; nucleus pulposus; phantom model; radicular pain; response; socioeconomics; success; surgery outcome; temporal measurement

PROJECT SUMMARY Low back pain (LBP) is a major clinical and socioeconomic global health burden. In fact, LBP affects nearly all of us at least once in our lives, and in ~20% the condition becomes chronic. The intervertebral disc (IVD) consists of a proteoglycan (PG)-rich nucleus pulposus (NP) surrounded by a collagenous annulus fibrosus (AF) that together provide support, transmit complex loads and motion of the spine. With aging, the IVD undergoes progressive and irreversible degenerative changes that often lead to LBP. Several techniques have been utilized to characterize the IVD, using animal or human cadaver models. While these studies can provide important data, internal disc mechanics may have different characteristics and quantifying the behavior of internal disc mechanics is technically challenging for in-vivo applications in humans. Therefore, we hypothesize that MRI studies of the lumbar IVDs performed under different static mechanical loading states (e.g., rest, during loading and recovery), using a flexible dynamic Golden-angle Radial Sparse Parallel (GRASP) MRI technique, could be used to better quantify disc mechanics in-vivo. The overarching goal of this R21 proposal is to develop a framework for non-invasive evaluation of in-vivo lumbar IVD mechanics (e.g., strain mapping in L1/L2-L5/S1) in response to MRI-compatible mechanical loading. For this purpose, we will utilize a fast, flexible dynamic Golden-angle Radial Sparse Parallel (GRASP)-MRI acquisition, for quantitative assessment of biomechanical characterization of lumbar IVDs on a standard clinical 3T scanner in a clinically feasible scan time, employing compressed sensing (CS), parallel imaging (PI), golden angle radial sampling and an optical flow algorithm.

项目摘要 腰痛（LBP）是主要的临床和社会经济全球健康负担。实际上，LBP几乎影响 我们一生中至少有一次，在约20％的情况下，病情变得慢性。椎间盘（IVD）包括 蛋白聚糖（Pg） - 富含胶原核（NP），周围环绕着胶原蛋白纤维（AF） 共同提供支撑，传输复合载荷和脊柱的运动。随着衰老，IVD经历 渐进性和不可逆转的退化性变化通常会导致LBP。已经使用了几种技术 使用动物或人尸体模型来表征IVD。尽管这些研究可以提供重要数据，但 内部光盘力学可能具有不同的特征并量化内部光盘的行为 力学在技术上对人类的体内应用方面的应用具有挑战性。因此，我们假设MRI 对在不同静态机械载荷状态下进行的腰椎IVD的研究（例如，静止，在加载过程中 恢复），使用灵活的动态金角径向稀疏平行（grasp）MRI技术，可能是 用于在体内更好地量化光盘力学。 该R21提案的总体目标是开发一个无创评估的框架 IVD力学（例如，L1/L2-L5/S1中的应变映射）响应MRI兼容的机械负载。为了 此目的，我们将利用快速，灵活的动态金角径向稀疏平行（grasp）-MRI 获取，用于定量评估标准临床上腰ivds的生物力学表征 使用压缩感（CS），平行成像（PI），金色的3T扫描仪在临床上可行的扫描时间中 角度径向采样和光流算法。