Intervertebral Disc Mechanics with Functional GRASP-MRI

具有功能性 GRASP-MRI 的椎间盘力学

• 批准号: 10328260
• 负责人: Ravinder Regatte
• 金额: $ 18.46万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10328260
• 关键词: Address; Affect; Age; Aging; Algorithms; Anatomy; Animals; Back Pain; Behavior; Biochemical; Cadaver; Cattle; Characteristics; Chronic; Clinical; Complex; Data; Deformity; Diagnosis; Diffusion; Evaluation; Gender; Goals; Histology; Human; Image; Imaging Techniques; Individual; Intervertebral disc structure; Lead; Life Style; Low Back Pain; Low Prevalence; Magnetic Resonance Imaging; Measurement; Mechanics; Modeling; Motion; Noise; Opioid; Optics; Pain; Pathology; Performance; Posture; Prevalence; Property; Proteoglycan; Protocols documentation; Radial; Recovery; Relaxation; Reporting; Reproducibility; Resolution; Rest; Sampling; Scanning; Silicone Gels; Source; Spinal; Spinal Stenosis; Spine surgery; Spondylolisthesis; Supination; Symptoms; T2 weighted imaging; Techniques; Testing; Time; Translations; Validation; Vertebral column; base; biomechanical test; discogenic pain; flexibility; functional disability; global health; healthy volunteer; imaging study; in vivo; in vivo evaluation; intervertebral disk degeneration; mechanical load; non-invasive imaging; normal aging; nucleus pulposus; phantom model; radicular pain; response; socioeconomics; success; surgery outcome; temporal measurement

PROJECT SUMMARY Low back pain (LBP) is a major clinical and socioeconomic global health burden. In fact, LBP affects nearly all of us at least once in our lives, and in ~20% the condition becomes chronic. The intervertebral disc (IVD) consists of a proteoglycan (PG)-rich nucleus pulposus (NP) surrounded by a collagenous annulus fibrosus (AF) that together provide support, transmit complex loads and motion of the spine. With aging, the IVD undergoes progressive and irreversible degenerative changes that often lead to LBP. Several techniques have been utilized to characterize the IVD, using animal or human cadaver models. While these studies can provide important data, internal disc mechanics may have different characteristics and quantifying the behavior of internal disc mechanics is technically challenging for in-vivo applications in humans. Therefore, we hypothesize that MRI studies of the lumbar IVDs performed under different static mechanical loading states (e.g., rest, during loading and recovery), using a flexible dynamic Golden-angle Radial Sparse Parallel (GRASP) MRI technique, could be used to better quantify disc mechanics in-vivo. The overarching goal of this R21 proposal is to develop a framework for non-invasive evaluation of in-vivo lumbar IVD mechanics (e.g., strain mapping in L1/L2-L5/S1) in response to MRI-compatible mechanical loading. For this purpose, we will utilize a fast, flexible dynamic Golden-angle Radial Sparse Parallel (GRASP)-MRI acquisition, for quantitative assessment of biomechanical characterization of lumbar IVDs on a standard clinical 3T scanner in a clinically feasible scan time, employing compressed sensing (CS), parallel imaging (PI), golden angle radial sampling and an optical flow algorithm.

项目概要 腰痛（LBP）是一项重大的临床和社会经济全球健康负担。事实上，腰痛几乎影响所有 我们一生中至少会遇到一次这种情况，并且约 20% 的人这种情况会变成慢性。椎间盘 (IVD) 包括 富含蛋白多糖（PG）的髓核（NP）被胶原纤维环（AF）包围， 共同提供支撑、传递脊柱的复杂负载和运动。随着年龄的增长，IVD 会发生变化 进行性和不可逆的退行性变化，通常会导致 LBP。使用了多种技术 使用动物或人类尸体模型来表征 IVD。虽然这些研究可以提供重要数据， 内部椎间盘力学可能具有不同的特征并量化内部椎间盘的行为 力学对于人类体内应用来说在技术上具有挑战性。因此，我们假设 MRI 在不同静态机械负载状态下（例如休息、负载期间）进行腰椎 IVD 的研究 和恢复），使用灵活的动态金角径向稀疏并行（GRASP）MRI技术，可以 用于更好地量化体内椎间盘力学。 该 R21 提案的总体目标是开发一个用于体内腰椎非侵入性评估的框架 IVD 力学（例如，L1/L2-L5/S1 中的应变映射）响应 MRI 兼容的机械负载。为了 为此，我们将利用快速、灵活的动态黄金角径向稀疏并行 (GRASP)-MRI 采集，用于在标准临床上定量评估腰椎 IVD 的生物力学特征 3T 扫描仪在临床上可行的扫描时间内采用压缩传感 (CS)、并行成像 (PI)、黄金 角度径向采样和光流算法。