Intervertebral Disc Mechanics with Functional GRASP-MRI

具有功能性 GRASP-MRI 的椎间盘力学

• 批准号: 10328260
• 负责人: Ravinder Regatte
• 金额: $ 18.46万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10328260
• 关键词: Address; Affect; Age; Aging; Algorithms; Anatomy; Animals; Back Pain; Behavior; Biochemical; Cadaver; Cattle; Characteristics; Chronic; Clinical; Complex; Data; Deformity; Diagnosis; Diffusion; Evaluation; Gender; Goals; Histology; Human; Image; Imaging Techniques; Individual; Intervertebral disc structure; Lead; Life Style; Low Back Pain; Low Prevalence; Magnetic Resonance Imaging; Measurement; Mechanics; Modeling; Motion; Noise; Opioid; Optics; Pain; Pathology; Performance; Posture; Prevalence; Property; Proteoglycan; Protocols documentation; Radial; Recovery; Relaxation; Reporting; Reproducibility; Resolution; Rest; Sampling; Scanning; Silicone Gels; Source; Spinal; Spinal Stenosis; Spine surgery; Spondylolisthesis; Supination; Symptoms; T2 weighted imaging; Techniques; Testing; Time; Translations; Validation; Vertebral column; base; biomechanical test; discogenic pain; flexibility; functional disability; global health; healthy volunteer; imaging study; in vivo; in vivo evaluation; intervertebral disk degeneration; mechanical load; non-invasive imaging; normal aging; nucleus pulposus; phantom model; radicular pain; response; socioeconomics; success; surgery outcome; temporal measurement

PROJECT SUMMARY Low back pain (LBP) is a major clinical and socioeconomic global health burden. In fact, LBP affects nearly all of us at least once in our lives, and in ~20% the condition becomes chronic. The intervertebral disc (IVD) consists of a proteoglycan (PG)-rich nucleus pulposus (NP) surrounded by a collagenous annulus fibrosus (AF) that together provide support, transmit complex loads and motion of the spine. With aging, the IVD undergoes progressive and irreversible degenerative changes that often lead to LBP. Several techniques have been utilized to characterize the IVD, using animal or human cadaver models. While these studies can provide important data, internal disc mechanics may have different characteristics and quantifying the behavior of internal disc mechanics is technically challenging for in-vivo applications in humans. Therefore, we hypothesize that MRI studies of the lumbar IVDs performed under different static mechanical loading states (e.g., rest, during loading and recovery), using a flexible dynamic Golden-angle Radial Sparse Parallel (GRASP) MRI technique, could be used to better quantify disc mechanics in-vivo. The overarching goal of this R21 proposal is to develop a framework for non-invasive evaluation of in-vivo lumbar IVD mechanics (e.g., strain mapping in L1/L2-L5/S1) in response to MRI-compatible mechanical loading. For this purpose, we will utilize a fast, flexible dynamic Golden-angle Radial Sparse Parallel (GRASP)-MRI acquisition, for quantitative assessment of biomechanical characterization of lumbar IVDs on a standard clinical 3T scanner in a clinically feasible scan time, employing compressed sensing (CS), parallel imaging (PI), golden angle radial sampling and an optical flow algorithm.

项目摘要 下背痛（LBP）是一种主要的临床和社会经济全球健康负担。事实上，LBP几乎影响所有 在我们的生活中至少有一次，并且在20%的情况下成为慢性病。椎间盘（IVD） 富含蛋白多糖（PG）的髓核（NP）被胶原纤维环（AF）包围， 一起提供支撑、传递复杂的负荷和脊柱的运动。随着老化，IVD经历 进行性和不可逆的退行性变化，往往导致LBP。已经使用了几种技术 使用动物或人尸体模型表征IVD。虽然这些研究可以提供重要的数据， 内部椎间盘力学可能具有不同的特征， 力学对于人体的体内应用在技术上具有挑战性。因此，我们假设MRI 在不同静态机械负荷状态下进行的腰椎IVD的研究（例如，静止，加载期间 和恢复），使用灵活的动态黄金角径向稀疏并行（GRASP）MRI技术， 用于更好地量化体内椎间盘力学。 这项R21提案的首要目标是开发一个框架，用于体内腰椎间盘突出症的非侵入性评估。 IVD机械师（例如，L1/L2-L5/S1中的应变映射）。为 为此，我们将利用快速、灵活的动态黄金角径向稀疏并行（GRASP）-MRI 采集，用于在标准临床试验中定量评估腰椎IVD的生物力学特征 3 T扫描仪在临床可行的扫描时间内，采用压缩感知（CS），并行成像（PI），黄金 角度径向采样和光流算法。