Rapid Quantitative Assessment of Knee Joint with Compressed Sensing

利用压缩感知对膝关节进行快速定量评估

基本信息

项目摘要

PROJECT SUMMARY Osteoarthritis (OA) is a degenerative joint disease, affecting more than 27 million people in the United States alone. This large affected population and the severe consequent debility of OA lead to significant expenses to the health care system. OA is characterized by biochemical, structural and morphologic degradation of components of the extracellular matrix (ECM) of articular cartilage. The ECM is composed of primarily two groups of macromolecules including proteoglycan (PG) and collagen fibers. Early diagnosis of cartilage degeneration would require the ability to non-invasively detect changes in PG concentration and collagen integrity before morphological changes occur. T1ρ and T2 relaxation times are affected by these pathological processes and are the most widely used biochemical cartilage MRI sequences worldwide. . The overarching goal of this proposal is to develop, optimize, and translate high spatial resolution 3D-isotropic- MRI sequence (700µmX700µmX700µm) for simultaneous assessment of morphometry and biexponential 3D- T1ρ (T2) mapping sequences (each protocol under 10 minutes) for improved quantitative assessment of morphological (cartilage thickness and volume) and biochemical characterization of cartilage on a standard clinical 3T scanner employing combinations of compressed sensing (CS) and parallel imaging (PI). The proposed accelerated, isotropic, high spatial resolution, multicomponent 3D-T1ρ (T2) mapping techniques can be easily incorporated into routine clinical protocols for biochemical assessment of cartilage in addition to standard morphological evaluation and could serve as future imaging biomarkers for disease modifying therapies for OA. The outcome of this proposed study will significantly impact our ability for personalized treatment regimens and possibly prevent the development of premature OA.
项目总结

项目成果

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Ravinder Regatte其他文献

Ravinder Regatte的其他文献

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{{ truncateString('Ravinder Regatte', 18)}}的其他基金

Multiparametric Mapping of Knee Joint with Magnetic Resonance Fingerprinting
膝关节磁共振指纹多参数绘图
  • 批准号:
    10541223
  • 财政年份:
    2021
  • 资助金额:
    $ 62.11万
  • 项目类别:
Multiparametric Mapping of Knee Joint with Magnetic Resonance Fingerprinting
膝关节磁共振指纹多参数绘图
  • 批准号:
    10115230
  • 财政年份:
    2021
  • 资助金额:
    $ 62.11万
  • 项目类别:
Data-Driven Learning Framework for Fast Quantitative Knee Joint Mapping
用于快速定量膝关节绘图的数据驱动学习框架
  • 批准号:
    10430275
  • 财政年份:
    2021
  • 资助金额:
    $ 62.11万
  • 项目类别:
Data-Driven Learning Framework for Fast Quantitative Knee Joint Mapping
用于快速定量膝关节绘图的数据驱动学习框架
  • 批准号:
    10296235
  • 财政年份:
    2021
  • 资助金额:
    $ 62.11万
  • 项目类别:
Intervertebral Disc Mechanics with Functional GRASP-MRI
具有功能性 GRASP-MRI 的椎间盘力学
  • 批准号:
    10328260
  • 财政年份:
    2021
  • 资助金额:
    $ 62.11万
  • 项目类别:
Zero Echo Time Imaging of Knee Joint
膝关节零回波时间成像
  • 批准号:
    9893211
  • 财政年份:
    2020
  • 资助金额:
    $ 62.11万
  • 项目类别:
Rapid Quantitative Assessment of Knee Joint with Compressed Sensing
利用压缩感知对膝关节进行快速定量评估
  • 批准号:
    10686034
  • 财政年份:
    2020
  • 资助金额:
    $ 62.11万
  • 项目类别:
Rapid Quantitative Assessment of Knee Joint with Compressed Sensing
利用压缩感知对膝关节进行快速定量评估
  • 批准号:
    10227958
  • 财政年份:
    2020
  • 资助金额:
    $ 62.11万
  • 项目类别:
Imaging Biomarkers of Knee Osteoarthritis
膝骨关节炎的影像生物标志物
  • 批准号:
    9323286
  • 财政年份:
    2016
  • 资助金额:
    $ 62.11万
  • 项目类别:
Imaging Biomarkers of Knee Osteoarthritis
膝骨关节炎的影像生物标志物
  • 批准号:
    9532083
  • 财政年份:
    2016
  • 资助金额:
    $ 62.11万
  • 项目类别:

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