Rapid Quantitative Assessment of Knee Joint with Compressed Sensing
利用压缩感知对膝关节进行快速定量评估
基本信息
- 批准号:10455507
- 负责人:
- 金额:$ 62.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-03 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAffectBiochemicalBiological ModelsBovine CartilageCartilageClinicalClinical ProtocolsCollagenCollagen FiberDataDegenerative polyarthritisDevelopmentDiagnosticDiseaseEarly DiagnosisEvaluationExtracellular MatrixFutureGoalsHealthcare SystemsHistologyHumanHydration statusImageImaging TechniquesJointsKnee OsteoarthritisKnee jointLeadMagnetic Resonance ImagingMeniscus structure of jointMethodsModelingMorphologyMusculoskeletalOutcomePainPathologic ProcessesPatientsPerformancePersonsPopulationProteoglycanProtocols documentationRelaxationResearch PersonnelResolutionSamplingScanningSliceSpecificityStructureT2 weighted imagingTechniquesTherapeutic AgentsThickTimeTissue EngineeringTissuesTranslatingTreatment ProtocolsUnited StatesValidationWaterarticular cartilagebasecartilage degradationcohortdata spaceefficacy evaluationhealingimaging biomarkerimprovedin vivomacromoleculemorphometrynon-invasive imagingnovelpersonalized medicineprematurepreventreconstructionrepaired
项目摘要
PROJECT SUMMARY
Osteoarthritis (OA) is a degenerative joint disease, affecting more than 27 million people in the United States
alone. This large affected population and the severe consequent debility of OA lead to significant expenses to
the health care system. OA is characterized by biochemical, structural and morphologic degradation of
components of the extracellular matrix (ECM) of articular cartilage. The ECM is composed of primarily two
groups of macromolecules including proteoglycan (PG) and collagen fibers. Early diagnosis of cartilage
degeneration would require the ability to non-invasively detect changes in PG concentration and collagen
integrity before morphological changes occur. T1ρ and T2 relaxation times are affected by these pathological
processes and are the most widely used biochemical cartilage MRI sequences worldwide. .
The overarching goal of this proposal is to develop, optimize, and translate high spatial resolution 3D-isotropic-
MRI sequence (700µmX700µmX700µm) for simultaneous assessment of morphometry and biexponential 3D-
T1ρ (T2) mapping sequences (each protocol under 10 minutes) for improved quantitative assessment of
morphological (cartilage thickness and volume) and biochemical characterization of cartilage on a standard
clinical 3T scanner employing combinations of compressed sensing (CS) and parallel imaging (PI). The
proposed accelerated, isotropic, high spatial resolution, multicomponent 3D-T1ρ (T2) mapping techniques can
be easily incorporated into routine clinical protocols for biochemical assessment of cartilage in addition to
standard morphological evaluation and could serve as future imaging biomarkers for disease modifying
therapies for OA. The outcome of this proposed study will significantly impact our ability for personalized
treatment regimens and possibly prevent the development of premature OA.
项目总结
骨关节炎(OA)是一种退行性关节疾病,在美国有2700多万人患病
独自一人。这一庞大的受影响人口以及随之而来的严重的办公自动化能力的丧失导致了大量的费用
医疗保健系统。OA的特征是生物化学、结构和形态上的降解
关节软骨细胞外基质(ECM)成分。ECM主要由两个部分组成
包括蛋白多糖(PG)和胶原纤维在内的一组大分子。软骨的早期诊断
退化需要非侵入性检测PG浓度和胶原蛋白变化的能力
在形态发生变化之前保持完整性。T1ρ和T2松弛时间受这些病理因素的影响
是目前世界上使用最广泛的生物化学软骨磁共振序列。。
该建议的总体目标是开发、优化和转换高空间分辨率的3D-各向同性-
MRI序列(700微米×700微米×700微米),用于同时评估形态测量和双指数3D-
T1ρ(T2)映射序列(每个协议不超过10分钟),以改进定量评估
标准软骨的形态(软骨厚度和体积)和生化特征
采用压缩传感(CS)和并行成像(PI)相结合的临床3T扫描仪。这个
建议的加速、各向同性、高空间分辨率、多分量3D-T1ρ(T2)映射技术可以
可轻松合并到常规临床方案中,用于软骨生化评估
标准的形态评估,可作为未来疾病修饰的成像生物标记物
治疗骨性关节炎。这项拟议研究的结果将显著影响我们的个性化能力
治疗方案,并可能预防早产儿骨性关节炎的发展。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Ravinder Regatte其他文献
Ravinder Regatte的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Ravinder Regatte', 18)}}的其他基金
Multiparametric Mapping of Knee Joint with Magnetic Resonance Fingerprinting
膝关节磁共振指纹多参数绘图
- 批准号:
10541223 - 财政年份:2021
- 资助金额:
$ 62.11万 - 项目类别:
Multiparametric Mapping of Knee Joint with Magnetic Resonance Fingerprinting
膝关节磁共振指纹多参数绘图
- 批准号:
10115230 - 财政年份:2021
- 资助金额:
$ 62.11万 - 项目类别:
Data-Driven Learning Framework for Fast Quantitative Knee Joint Mapping
用于快速定量膝关节绘图的数据驱动学习框架
- 批准号:
10430275 - 财政年份:2021
- 资助金额:
$ 62.11万 - 项目类别:
Data-Driven Learning Framework for Fast Quantitative Knee Joint Mapping
用于快速定量膝关节绘图的数据驱动学习框架
- 批准号:
10296235 - 财政年份:2021
- 资助金额:
$ 62.11万 - 项目类别:
Intervertebral Disc Mechanics with Functional GRASP-MRI
具有功能性 GRASP-MRI 的椎间盘力学
- 批准号:
10328260 - 财政年份:2021
- 资助金额:
$ 62.11万 - 项目类别:
Rapid Quantitative Assessment of Knee Joint with Compressed Sensing
利用压缩感知对膝关节进行快速定量评估
- 批准号:
10686034 - 财政年份:2020
- 资助金额:
$ 62.11万 - 项目类别:
Rapid Quantitative Assessment of Knee Joint with Compressed Sensing
利用压缩感知对膝关节进行快速定量评估
- 批准号:
10227958 - 财政年份:2020
- 资助金额:
$ 62.11万 - 项目类别:
相似海外基金
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 62.11万 - 项目类别:
Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 62.11万 - 项目类别:
Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 62.11万 - 项目类别:
Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 62.11万 - 项目类别:
Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 62.11万 - 项目类别:
Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 62.11万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 62.11万 - 项目类别:
Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
- 批准号:
2301846 - 财政年份:2023
- 资助金额:
$ 62.11万 - 项目类别:
Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 62.11万 - 项目类别:
Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
- 批准号:
23K16076 - 财政年份:2023
- 资助金额:
$ 62.11万 - 项目类别:
Grant-in-Aid for Early-Career Scientists