Zero Echo Time Imaging of Knee Joint
膝关节零回波时间成像
基本信息
- 批准号:9893211
- 负责人:
- 金额:$ 18.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-01-01 至 2021-11-30
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAffectBiochemicalBiochemical MarkersBiological ModelsBiomechanicsCartilageCattleClinicalCollagenComputer softwareDegenerative polyarthritisDevelopmentDiagnosisDiseaseDisease ProgressionExtracellular MatrixFatty acid glycerol estersFourier TransformFutureGoalsHealthHistologyHumanHyaline CartilageHydration statusImageJointsKnee jointLigamentsMagnetic Resonance ImagingMeniscus structure of jointMethodsMinorModelingMorphologyMusculoskeletalPerformancePhysiologic pulsePlayProteoglycanProtonsQuantitative EvaluationsRadialRelaxationReportingResearchResearch PersonnelRoleSamplingScanningSignal TransductionSolidStructureTechniquesTechnologyTendon structureTestingTimeTissuesTranslatingUnited StatesValidationVariantWaterarticular cartilagebasebonecalcificationdata spacehealthy volunteerimage reconstructionimprovedin vivojoint destructionmacromoleculenon-invasive imagingnovelphantom modelradio frequencyskeletal disorder
项目摘要
PROJECT SUMMARY
Human knee joints are composed of many different tissues including articular cartilage, calcified cartilage,
menisci, ligaments, tendons and bone all of which are important for the health of the joint. Recent research
suggests that osteoarthritis (OA) is not just a disease of hyaline cartilage, but rather of the entire joint. Several
researchers have demonstrated that the T1ρ relaxation time is more sensitive to proteoglycan (PG) content of
the cartilage, while T2 relaxation time is more sensitive to collagen orientation, integrity of network and
hydration. The short T1ρ menisci, calcified cartilage, tendons, and ligaments are integral part of joint
biomechanics and abnormalities in these tissues may impact joint degeneration and onset of OA. Therefore,
quantitative evaluation of relaxation times in these tissues may provide sensitive biochemical markers for early
OA diagnosis, and disease progression. However, conventional T1ρ-MRI sequences (e.g., GRE and FSE
readouts) are limited value in detecting early macromolecular changes in semi-solid short T1ρ tissues or tissue
components such as menisci, ligaments and tendons. Most of the knee joint structures, including menisci,
ligaments and tendons have both dominant short (bound/restricted water associated with collagen and/or
proteoglycans) and minor long (less restricted/free water associated with macromolecules) components.
Therefore, there is a significant need for reliable, non-invasive, time efficient, ZTE-based biexponential 3D-T1ρ
imaging sequence for quantitative assessment of semi-solid structures in the knee joint that could detect the
early biochemical changes in extracellular matrix (ECM) with short and long relaxation components and their
corresponding fractions.
The overarching goal of this R21 proposal is to develop, optimize, and translate ZTE (PETRA)-based
biexponential 3D-T1ρ imaging pulse sequence for improved quantitative assessment of morphological and
biochemical characterization of semi-solid short T1ρ structures in the knee joint (menisci, ligaments and
tendons) on a standard clinical 3T scanner employing multicoil compressed sensing (CS).
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ravinder Regatte其他文献
Ravinder Regatte的其他文献
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{{ truncateString('Ravinder Regatte', 18)}}的其他基金
Multiparametric Mapping of Knee Joint with Magnetic Resonance Fingerprinting
膝关节磁共振指纹多参数绘图
- 批准号:
10541223 - 财政年份:2021
- 资助金额:
$ 18.65万 - 项目类别:
Multiparametric Mapping of Knee Joint with Magnetic Resonance Fingerprinting
膝关节磁共振指纹多参数绘图
- 批准号:
10115230 - 财政年份:2021
- 资助金额:
$ 18.65万 - 项目类别:
Data-Driven Learning Framework for Fast Quantitative Knee Joint Mapping
用于快速定量膝关节绘图的数据驱动学习框架
- 批准号:
10430275 - 财政年份:2021
- 资助金额:
$ 18.65万 - 项目类别:
Data-Driven Learning Framework for Fast Quantitative Knee Joint Mapping
用于快速定量膝关节绘图的数据驱动学习框架
- 批准号:
10296235 - 财政年份:2021
- 资助金额:
$ 18.65万 - 项目类别:
Intervertebral Disc Mechanics with Functional GRASP-MRI
具有功能性 GRASP-MRI 的椎间盘力学
- 批准号:
10328260 - 财政年份:2021
- 资助金额:
$ 18.65万 - 项目类别:
Rapid Quantitative Assessment of Knee Joint with Compressed Sensing
利用压缩感知对膝关节进行快速定量评估
- 批准号:
10455507 - 财政年份:2020
- 资助金额:
$ 18.65万 - 项目类别:
Rapid Quantitative Assessment of Knee Joint with Compressed Sensing
利用压缩感知对膝关节进行快速定量评估
- 批准号:
10686034 - 财政年份:2020
- 资助金额:
$ 18.65万 - 项目类别:
Rapid Quantitative Assessment of Knee Joint with Compressed Sensing
利用压缩感知对膝关节进行快速定量评估
- 批准号:
10227958 - 财政年份:2020
- 资助金额:
$ 18.65万 - 项目类别:
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