REPOSITORY PULL FOR OXIDATIVE STRESS AND PLACENTAL AGING

氧化应激和胎盘老化的储存库拉动

• 批准号: 10329850
• 负责人: OGUZ MANDACI
• 金额: $ 0.28万
• 依托单位: FISHER BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-03 至 2022-09-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10329850
• 关键词: Age; Aging; Biological; Biological Markers; Blood Circulation; Cell Aging; DNA Damage; DNA Methylation; Fetal Growth; Functional disorder; Homeostasis; Inflammation; Low Birth Weight Infant; Measures; Minnesota; National Institute of Child Health and Human Development; Oxidative Stress; Pathologic; Placenta; Plasma; Pre-Eclampsia; Pregnancy Complications; Premature Birth; Premature aging syndrome; Residual state; Sampling; Shipping; Signal Transduction; Specimen; Telomerase; Tissues; Universities; histopathological examination; methylation biomarker; premature; repository; stillbirth

Altered placental aging is recognized to be a potential mechanism in the pathophysiology of a scope of pregnancy complications related to placental dysfunction. Several studies have found that premature aging of the placenta is associated with preeclampsia, low birth weight, stillbirth, and preterm birth. The biological age of a tissue can be estimated with high accuracy using DNA methylation markers. This “clock” is particularly valuable in studies of placental aging because traditional histopathological examination and telomerase homeostasis markers may not capture subtle aging alterations and premature cellular senescence caused by DNA damage due to oxidative stress. Cellular oxidative stress within the placenta leads to increased release of several factors into the maternal circulation. Therefore, biomarkers that the placenta excretes into the maternal circulation may give early signals of pathological changes in a prematurely aging placenta. Biomarkers of oxidative stress, inflammation glycemic status will be measured in maternal plasma from the NICHD Fetal Growth study.

改变胎盘老化被认为是一个潜在的机制， 与胎盘功能障碍有关的一系列妊娠并发症的病理生理学。几 研究发现，胎盘的过早老化与先兆子痫、低出生率有关。 体重、死胎和早产。组织的生物学年龄可以通过以下方式估计： 使用DNA甲基化标记的高准确性。 这个“时钟”在以下方面特别有价值： 传统组织病理学检查与端粒酶对胎盘老化的研究 稳态标记物可能无法捕捉细微的衰老变化和细胞过早衰老 是由氧化应激导致的DNA损伤引起的 胎盘内的细胞氧化应激导致几种因子释放增加， 母体循环 因此，胎盘分泌到胎盘中的生物标志物 母体血液循环可能给出早期信号 的 病理 变化 在 一 过早 老化 胎盘 生物标记 的 氧化 将在NICHD胎儿生长的母体血浆中测量应激、炎症和血糖状态 study.