REPOSITORY PULL FOR OXIDATIVE STRESS AND PLACENTAL AGING

胎盘老化的改变被认为是一种潜在的机制 与胎盘功能障碍相关的一系列妊娠并发症的病理生理学。几个 研究发现，胎盘过早老化与先兆子痫、低出生有关 体重、死产和早产。组织的生物年龄可以用以下公式来估计 使用DNA甲基化标记的准确性很高。这个“钟”在中国特别有价值。 传统组织病理学检查和端粒酶对胎盘老化的研究 动态平衡标记物可能无法捕捉到细微的衰老变化和细胞过早衰老 由氧化应激引起的DNA损伤引起。 胎盘内的细胞氧化应激导致几种因子释放增加 母体循环。因此，胎盘排泄到体内的生物标志物 母体循环可能会给出早期的病理变化信号 胎盘过早老化。NICHD胎儿生长过程中母体血浆中氧化应激、炎症和血糖状态的生物标志物将被测量 学习。

Altered placental aging is recognized to be a potential mechanism in the pathophysiology of a scope of pregnancy complications related to placental dysfunction. Several studies have found that premature aging of the placenta is associated with preeclampsia, low birth weight, stillbirth, and preterm birth. The biological age of a tissue can be estimated with high accuracy using DNA methylation markers. This “clock” is particularly valuable in studies of placental aging because traditional histopathological examination and telomerase homeostasis markers may not capture subtle aging alterations and premature cellular senescence caused by DNA damage due to oxidative stress. Cellular oxidative stress within the placenta leads to increased release of several factors into the maternal circulation. Therefore, biomarkers that the placenta excretes into the maternal circulation may give early signals of pathological changes in a prematurely aging placenta. Biomarkers of oxidative stress, inflammation glycemic status will be measured in maternal plasma from the NICHD Fetal Growth study.