STORAGE OF NUMOM2B FETAL DNA ALIQUOTS FROM CORD BLOOD FOR THE PREGNANCY AND PERINATOLOGY BRANCH OF NICHD

NICHD 妊娠和围产期分支的脐带血 NUMOM2B 胎儿 DNA 等份的储存

• 批准号: 10268324
• 负责人: OGUZ MANDACI
• 金额: $ 12.86万
• 依托单位: FISHER BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-17 至 2025-09-16
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10268324
• 关键词: Aliquot; Arteries; Bar Codes; Blood specimen; Cervical; Collection; DNA; Ensure; Equipment and supply inventories; Etiology; Evaluation; Family; Fetal Growth; First Pregnancy Trimester; Funding; Future; Indiana; Measurement; Measures; Medical History; National Institute of Child Health and Human Development; Nulliparity; Observational Study; Online Systems; Participant; Perinatology; Placenta; Plasma; Pregnancy; Psychosocial Assessment and Care; Psychosocial Factor; Recording of previous events; Research Personnel; Sampling; Services; Shipping; Ships; Specimen; Time; Tube; Ultrasonography; Umbilical Cord Blood; Universities; Urine; Uterus; Vagina; Woman; adverse pregnancy outcome; clinical research site; cost; demographics; fetal; maternal serum; nutrition; programs; prospective; repository

The NuMoM2b study was a prospective observational study of over 10,000 nulliparous women followed from the first trimester through delivery to understand the mechanism and etiology of adverse pregnancy outcomes starting in the first trimester. It was conducted at eight clinical sites. All study participants underwent serial evaluations including demographics, nutrition, family history, maternal anthropometric measurements, medical history, assessments of psychosocial factors, ultrasound measures of fetal growth, placental function (uterine artery Doppler) and biospecimen collection (maternal serum, plasma, urine, cervical/vaginal samples, placenta at delivery). Dr. Haas of Indiana University will purify DNA from the cord blood specimens from each participant in the NuMom2b study. At his expense he will receive shipment of and generate DNA from approximately 5,526 cord blood specimens. He will then return to NICHD three aliquots of 200 microliters of DNA at a concentration of 50ng/uL from each of the approximately 5,526 specimens. This will result in a total of 16,578 DNA specimens that will be available to approved researchers through programs such as NICHD DASH.

NuMoM2b研究是一项前瞻性观察研究，有超过10,000名产妇参加