STORAGE OF NUMOM2B FETAL DNA ALIQUOTS FROM CORD BLOOD FOR THE PREGNANCY AND PERINATOLOGY BRANCH OF NICHD

NuMoM2B研究是一项对10,000多名未产妇进行的前瞻性观察研究 妇女从怀孕的前三个月开始跟踪，直到分娩，以了解这一机制和 从妊娠早期开始的不良妊娠结局的病因。它是被执行的 在八个临床地点。所有研究参与者都接受了一系列评估，包括 人口学、营养学、家族史、产妇人体测量、医学 病史、心理社会因素评估、胎儿发育超声测量、胎盘 功能(子宫动脉多普勒)和生物量采集(母体血清、血浆、 尿液、宫颈/阴道样本、分娩时的胎盘)。 印第安纳大学的哈斯博士将从每个参与者的脐带血样本中提纯DNA 在nuMoM2B研究中。由他支付费用，他将收到发货的货物并从 大约5526份脐带血样本。然后他将返回NICHD三等分 200微升DNA，浓度为50 ng/ul，分别来自大约 5526个标本。这将导致总共16,578个DNA样本将通过NICHD DASH等项目提供给获得批准的研究人员。

The NuMoM2b study was a prospective observational study of over 10,000 nulliparous women followed from the first trimester through delivery to understand the mechanism and etiology of adverse pregnancy outcomes starting in the first trimester. It was conducted at eight clinical sites. All study participants underwent serial evaluations including demographics, nutrition, family history, maternal anthropometric measurements, medical history, assessments of psychosocial factors, ultrasound measures of fetal growth, placental function (uterine artery Doppler) and biospecimen collection (maternal serum, plasma, urine, cervical/vaginal samples, placenta at delivery). Dr. Haas of Indiana University will purify DNA from the cord blood specimens from each participant in the NuMom2b study. At his expense he will receive shipment of and generate DNA from approximately 5,526 cord blood specimens. He will then return to NICHD three aliquots of 200 microliters of DNA at a concentration of 50ng/uL from each of the approximately 5,526 specimens. This will result in a total of 16,578 DNA specimens that will be available to approved researchers through programs such as NICHD DASH.