REPOSITORY PULL FOR UPSTATE KIDS 2020

2020 年 UPSTATE KIDS 存储库拉取

• 批准号: 10360407
• 负责人: OGUZ MANDACI
• 金额: $ 0.11万
• 依托单位: FISHER BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-22 至 2023-07-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10360407
• 关键词: Age; Biological Assay; Blood; Blood specimen; Child; Conceptions; Contracts; DNA; Epigenetic Process; Equipment and supply inventories; Follow-Up Studies; Minnesota; Mothers; Plasma; Puberty; Residual state; Risk; Saliva; Sampling; Shipping; Ships; Specimen; Universities; Whole Blood; cardiovascular disorder risk; infertility treatment; repository; saliva sample; treatment effect

The purpose of the Upstate KIDS CVD Follow-up study is to determine if infertility treatment is associated with a risk cardiovascular disease or the timing of puberty. Studies have shown that some pubertal markers appear altered after IVF conception and early adrenarche may itself confer a risk of cardiovascular disease. Epigenetics may be the mechanism underlying treatment effects. The Upstate KIDS study consisted of children conceived by infertility treatment and children conceived naturally. In this follow-up study, specimens including blood and saliva were taken from children between the ages of 6 and 8. Blood was also taken from mothers to assess confounding by maternal CVD risk.

上州儿童心血管疾病随访研究的目的是确定不孕症治疗是否与心血管疾病风险或青春期时间有关。研究表明，一些青春期标志物在IVF受孕后出现改变，早期肾上腺初显本身可能会导致心血管疾病的风险。表观遗传学可能是治疗效果的机制。Upstate KIDS研究包括通过不孕治疗怀孕的孩子和自然怀孕的孩子。在这项后续研究中，包括血液和唾液在内的样本取自6至8岁的儿童。还从母亲身上采集血液，以评估母亲CVD风险的混杂因素。