REPOSITORY PULL FOR SUICIDE AND MATERNAL IMMUNE ACTIVITY STUDY

自杀和母体免疫活性研究的存储库拉取

• 批准号: 10017454
• 负责人: OGUZ MANDACI
• 金额: $ 2.47万
• 依托单位: FISHER BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-09 至 2021-09-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10017454
• 关键词: Age; Behavioral; Biological Markers; Cessation of life; Child; Cognitive; Data; Immune; Immune system; Link; Matched Group; National Institute of Child Health and Human Development; Nested Case-Control Study; Neurologic; Participant; Perinatal; Pregnancy; Resources; Risk; Sampling; Serum; Specimen; Suicide; United States; Vital Status; accomplished suicide; cost; experience; fetal; indexing; offspring; prenatal; repository; socioeconomics

This project requires accessing 2371 samples from the Collaborative Perinatal Project that have been stored at the repository at -20C. Given the non-optimal storage conditions and extreme age of the specimens it has been our experience that many of these samples are desiccated or evaporated to the degree that the required 3 ml serum is not attainable. Our last project using these samples we found 4% of the original samples requested were unavailable. The repository has noted that in some case this could be up to 40%. Thus, we are providing resources for the repository to pull an additional 25% specimens to cover the costs of repeated pulls to satisfy this request. This study will link data from 52,966 children born to participants in the United States Collaborative Perinatal Project (CPP) between 1959 – 1966 to the National Death Index, determine their vital status through 2013, and investigate the prenatal, socioeconomic, behavioral, cognitive, and neurologic risks for completed suicide. We will conduct a nested case-control study to investigate the contributions of gestational immune activity to fetal origins of suicide. The DIPHR has identified 2371 serum specimens in the NICHD-DIPHR repository from CPP participants from which we will compare levels of immune system biomarkers between offspring who died by suicide and a matched group of non-suicide controls. We hypothesize biomarker concentrations consistent with a perturbation of the maternal immune system.

该项目需要从合作围产期项目中获取2371个样本，这些样本已存储在-20℃的储存库中。根据我们的经验，鉴于标本的非最佳储存条件和极度陈年，其中许多样本被干燥或蒸发到无法获得所需的3毫升血清的程度。我们的上一个项目使用这些样本，我们发现4%的原始样本要求是不可用的。该储存库指出，在某些情况下，这一比例可能高达40%。因此，我们正在为资料库提供资源，以额外拉出25%的样本，以支付为满足这一请求而重复拉出的成本。 这项研究将把美国合作围产期项目(CPP)参与者在1959-1966年间所生的52,966名儿童的数据与国家死亡指数联系起来，确定他们到2013年的生命状况，并调查完全自杀的产前、社会经济、行为、认知和神经学风险。我们将进行一项嵌套式病例对照研究，以调查妊娠免疫活动对胎儿自杀起源的贡献。 DIPHR已经在NICHD-DIPHR库中鉴定了2371个来自CPP参与者的血清样本，我们将从这些样本中比较自杀死亡的后代和匹配的非自杀对照组之间的免疫系统生物标记物水平。我们假设生物标记物的浓度与母体免疫系统的扰动一致。