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中文摘要
翻译
国家牙科PBRN(网络)提供了一个独特的机会来进行有影响力的口腔健康研究。牙科实践是在“真实世界”人群中识别趋势和研究牙科保健提供策略的有效性和潜在益处的理想环境。CHR协调中心目前作为网络协调中心(NCC),并将继续实现以下目标,以支持成功申请NOT-DE-20-023:1.与网络领导建立富有成效的协作工作关系,并促进制定7年网络战略计划。NCC将会同国家网络主任(S)、节点主任和节点协调员清点现有 网络研究基础设施,评估和确定网络需求的优先顺序,制定战略目标,并为实现这些目标制定详细的工作计划;2.为网络提供中央协调。在目标1的基础上,NCC将开发流程、技术和其他资源,以最大限度地提高网络的效率和增加网络的影响;3.通过建立一个全面、综合、安全的网络研究网站(网络中心),将网络从业者数据库访问整合到网站中,并开发基于电子牙科和医疗健康记录数据的通用数据模型(CDM),增加网络资源。NCC将创建一个多功能网站,作为网络研究的主要枢纽。网络中心将提供一个交流平台、一个数据收集、管理和报告系统、一个科学审查系统,以及查阅全网和专门研究的文件。现有的从业者数据库将导入中心,并实施新的从业者调查,这两个来源都将与数据管理系统相连。我们还建议为牙科CDM开发仅可用于执行数据的内容和数据体系结构 研究,为设计研究提供初步数据,并确定要招募的患者或额外的后续行动。4.为审查、发展、实施和传播网络研究报告提供科学、统计和业务支助。国家协调委员会将创建和维护管理研究概念审查以及研究发展和实施的技术。NCC团队将继续提供支持积极研究团队所需的方法学、临床、监管、管理、操作和技术专业知识。国家协调委员会将制定多种数据收集战略,以及简化网络研究的核准和实施的程序和模板。在超过25年的时间里,NCC开发了大量的工具、技术、流程和政策来协调多中心的研究,它将为支持NCC提供坚实的基础。
英文摘要
The National Dental PBRN (Network) provides a unique opportunity to conduct impactful research in oral health. Dental practices are an ideal setting for identifying trends and studying effectiveness and potential benefits of dental care delivery strategies in “real-world” populations. The CHR Coordinating Center currently serves as the Network Coordinating Center (NCC) and will continue to carry out the following aims in support of successful applicants to NOT-DE-20-023: 1. Establish productive, collaborative working relationships with Network leadership and facilitate the development of a 7-year Network strategic plan. The NCC will work with the National Network Director(s), Node Directors and Node Coordinators to inventory existing Network research infrastructure, assess and prioritize the Network’s needs, craft strategic aims, and create a detailed work plan for achieving those aims; 2. Provide central coordination for the Network. Based on Aim 1, the NCC will develop processes, technologies and other resources to maximize the efficiency and increase the impact of the Network; 3. Augment Network resources by establishing a comprehensive, integrated, secure Network research website (the Network Hub), integrating the Network practitioner database access into the website, and developing a Common Data Model (CDM) based on electronic dental and medical health record data. The NCC will create a multi-function website that will serve as the primary hub for network research. The Network Hub will provide a communications platform, a data collection, management and reporting system, a scientific review system, and access to Network-wide and study-specific documents. The existing practitioner database will be imported to the Hub and a new practitioner surveys implemented and both sources will be linked with the data management system. We also propose developing content and data architecture for a dental CDM that can be used to carry out data only studies, provide preliminary data for designing studies, and identify patients for recruitment or additional follow-up. 4. Provide scientific, statistical and operational support for the review, development, implementation and dissemination of Network research studies. The NCC will create and maintain technologies to manage study concept review and study development and implementation. NCC teams will continue to provide the methodologic, clinical, regulatory, administrative, operational, and technical expertise needed to support active study teams. The NCC will develop multiple strategies for data collection, as well as procedures and templates to streamline the approval and implementation of Network studies. Over more than 25 years, the NCC has developed a large repertoire of tools, technologies, processes and policies to coordinate multi-center research studies, and it will provide a solid foundation to support the Network.
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National Dental Practice-Based Research Network: Coordinating Center
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Molecular Interaction Reconstruction of Rheumatoid Arthritis Therapies Using Clinical Data