The Cellular and Systems Biology of Sleep and Circadian Rhythms Training Program

睡眠和昼夜节律的细胞和系统生物学培训计划

• 批准号: 10214670
• 负责人: Robert W Greene
• 金额: $ 25.68万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10214670
• 关键词: Cellular biology; Circadian Rhythms; Sleep; Systems Biology; Training Programs

Project Summary This is a resubmission of a new competitive proposal for an NHLBI T32 training grant. Sleep/wake and circadian rhythms involve state changes of multisystem biological function that may not in themselves be vital to life but the systems under this modulatory control are vital to life. Further, optimal function of these systems, required for healthy living, is severely compromised in the absence of these intricately organized state changes. The regular and/or rhythmic occurrence of state changes is evolutionarily preserved and adverse outcomes in a variety of organ systems, including CNS, cardiovascular, respiratory, immune, and metabolic systems are associated with their disruption. However, the mechanisms, the mechanisms’ integration and both qualitative and quantitative impact of the state-change related modulation and overall health of the organism (including humans) is not well understood. An overall goal of this T32 proposal is to prepare a group of pre-doctoral and post-doctoral researchers to engage in the challenging endeavor of effective investigation to help remedy this vitally important gap in our biological understanding. Not only will the trainees receive in depth exposure and experience in effective application of multiple and integrated state of the art technologies and experimental approaches from world leaders, but additionally, strong integrative and collaborative interaction and facilitation of this interaction will be generated from our proposed structure within the newly developed Peter O’Donnell Brain Institute. This will enhance the trainee’s ability to engage in independent development of successful research programs that truly span the usual gulf from bench to bedside in a manner that integrates multiple biological systems across behavioral states as demanded by effective sleep/wake and circadian research. Finally, trainees will receive mentored experience in grant writing and in the communication and publication of integrative form of research and career counseling to enabling successful pursuit of a sleep and circadian research oriented career.

项目摘要 这是对NHLBI T32培训补助金的新的竞争性提案的重新提交。 睡眠/清醒和昼夜节律涉及多系统生物功能的状态变化， 可能对生命本身并不重要，但这种调节控制下的系统对 生活。此外，这些系统的最佳功能是健康生活所必需的，这是严重的 在没有这些错综复杂的组织状态变化的情况下妥协。 状态变化的规律性和/或节律性发生在进化上是保留的和不利的 各种器官系统的结果，包括中枢神经系统、心血管系统、呼吸系统、免疫系统和 新陈代谢系统与它们的破坏有关。然而，这些机制、 机制整合与状态变化的质与量的影响 生物体(包括人类)的相关调节和整体健康还没有被很好地理解。 这项T32提案的总体目标是准备一批博士后和博士后 研究人员将致力于富有挑战性的有效调查，以帮助补救这一问题 在我们的生物学理解中存在着至关重要的鸿沟。学员们不仅将深入了解 在有效应用多种综合技术方面的经验和经验 来自世界领导者的技术和实验方法，但另外，强大 将从以下方面产生整合和协作的互动并促进此互动 我们在新开发的Peter O‘Donnell脑研究所内提议的结构。这将是 增强学员成功从事自主研发研究的能力 真正跨越从长凳到床边的通常鸿沟的计划 有效睡眠/清醒所需的跨行为状态的多个生物系统 昼夜节律研究。最后，受训者将获得在赠款撰写和 传播和出版综合形式的研究和职业咨询，以使 成功追求以睡眠和昼夜节律研究为导向的职业。