The Cellular and Systems Biology of Sleep and Circadian Rhythms Training Program

项目摘要 这是一个新的竞争性提案NHLBI T32培训补助金的重新提交。 睡眠/觉醒和昼夜节律涉及多系统生物功能的状态变化， 可能本身对生命并不重要，但这种调节控制下的系统对生命至关重要。 生活此外，健康生活所需的这些系统的最佳功能， 在没有这些错综复杂的组织状态变化的情况下妥协。 状态变化的规则和/或节奏性发生在进化上被保留下来， 各种器官系统的结局，包括CNS、心血管、呼吸、免疫和 代谢系统与它们的破坏有关。然而，这些机制， 机制的整合以及状态变化的质和量的影响 生物体（包括人类）的相关调节和整体健康还没有很好地理解。 这个T32提案的总体目标是准备一组博士前和博士后 研究人员参与有效调查的挑战性奋进，以帮助解决这一问题 我们对生物学的理解存在着重大的差距。学员们不仅将深入了解 在有效应用多种综合最新技术方面的接触和经验 来自世界领先者的技术和实验方法，但此外， 综合性和协作性互动，并促进这种互动， 我们提议的新成立的彼得奥唐纳脑科学研究所。这将 提高受训者从事独立开发成功研究的能力 真正跨越通常的海湾从板凳到床边的方式，整合方案 有效睡眠/清醒所需的跨行为状态的多个生物系统， 昼夜节律研究最后，学员将获得撰写赠款和 交流和出版研究和职业咨询的综合形式， 成功追求睡眠和昼夜节律研究为导向的职业生涯。

Project Summary This is a resubmission of a new competitive proposal for an NHLBI T32 training grant. Sleep/wake and circadian rhythms involve state changes of multisystem biological function that may not in themselves be vital to life but the systems under this modulatory control are vital to life. Further, optimal function of these systems, required for healthy living, is severely compromised in the absence of these intricately organized state changes. The regular and/or rhythmic occurrence of state changes is evolutionarily preserved and adverse outcomes in a variety of organ systems, including CNS, cardiovascular, respiratory, immune, and metabolic systems are associated with their disruption. However, the mechanisms, the mechanisms’ integration and both qualitative and quantitative impact of the state-change related modulation and overall health of the organism (including humans) is not well understood. An overall goal of this T32 proposal is to prepare a group of pre-doctoral and post-doctoral researchers to engage in the challenging endeavor of effective investigation to help remedy this vitally important gap in our biological understanding. Not only will the trainees receive in depth exposure and experience in effective application of multiple and integrated state of the art technologies and experimental approaches from world leaders, but additionally, strong integrative and collaborative interaction and facilitation of this interaction will be generated from our proposed structure within the newly developed Peter O’Donnell Brain Institute. This will enhance the trainee’s ability to engage in independent development of successful research programs that truly span the usual gulf from bench to bedside in a manner that integrates multiple biological systems across behavioral states as demanded by effective sleep/wake and circadian research. Finally, trainees will receive mentored experience in grant writing and in the communication and publication of integrative form of research and career counseling to enabling successful pursuit of a sleep and circadian research oriented career.