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The Cellular and Systems Biology of Sleep and Circadian Rhythms Training Program

睡眠和昼夜节律的细胞和系统生物学培训计划

基本信息

批准号：
10453808
负责人：
Robert W Greene
金额：
$ 14.49万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10453808
关键词：
Cellular biology Circadian Rhythms Sleep Systems Biology Training Programs

项目摘要

Project Summary This is a resubmission of a new competitive proposal for an NHLBI T32 training grant. Sleep/wake and circadian rhythms involve state changes of multisystem biological function that may not in themselves be vital to life but the systems under this modulatory control are vital to life. Further, optimal function of these systems, required for healthy living, is severely compromised in the absence of these intricately organized state changes. The regular and/or rhythmic occurrence of state changes is evolutionarily preserved and adverse outcomes in a variety of organ systems, including CNS, cardiovascular, respiratory, immune, and metabolic systems are associated with their disruption. However, the mechanisms, the mechanisms’ integration and both qualitative and quantitative impact of the state-change related modulation and overall health of the organism (including humans) is not well understood. An overall goal of this T32 proposal is to prepare a group of pre-doctoral and post-doctoral researchers to engage in the challenging endeavor of effective investigation to help remedy this vitally important gap in our biological understanding. Not only will the trainees receive in depth exposure and experience in effective application of multiple and integrated state of the art technologies and experimental approaches from world leaders, but additionally, strong integrative and collaborative interaction and facilitation of this interaction will be generated from our proposed structure within the newly developed Peter O’Donnell Brain Institute. This will enhance the trainee’s ability to engage in independent development of successful research programs that truly span the usual gulf from bench to bedside in a manner that integrates multiple biological systems across behavioral states as demanded by effective sleep/wake and circadian research. Finally, trainees will receive mentored experience in grant writing and in the communication and publication of integrative form of research and career counseling to enabling successful pursuit of a sleep and circadian research oriented career.

项目概要这是重新提交 NHLBI T32 培训补助金的新竞争性提案。睡眠/觉醒和昼夜节律涉及多系统生物功能的状态变化，其本身可能对生命并不重要，但在这种调节控制下的系统对生命至关重要生活。此外，健康生活所需的这些系统的最佳功能也受到严重影响。如果没有这些错综复杂的组织状态变化，就会受到损害。状态变化的有规律和/或有节奏的发生在进化中被保留并且是不利的多种器官系统的结果，包括中枢神经系统、心血管、呼吸、免疫和代谢系统与其破坏有关。然而，机制、机制的整合以及状态变化的定性和定量影响生物体（包括人类）的相关调节和整体健康状况尚不清楚。 T32提案的总体目标是培养一批博士前和博士后研究人员致力于有效调查的挑战性工作，以帮助解决这一问题我们的生物学理解中存在着极其重要的差距。学员们不仅能够深入了解有效应用多种和综合最先进技术的接触和经验来自世界领先者的技术和实验方法，但此外，强大的整合和协作的互动以及这种互动的促进将产生于我们在新开发的彼得·奥唐纳脑研究所内提出的结构。这将增强学员独立开发成功研究的能力以整合的方式真正跨越从实验室到临床的通常鸿沟的计划根据有效睡眠/觉醒的要求，跨行为状态的多个生物系统昼夜节律研究。最后，学员将获得资助写作和项目实践方面的指导经验。交流和出版综合形式的研究和职业咨询，以实现成功追求以睡眠和昼夜节律研究为导向的职业。