Convergent graduate training in systems biology at Yale

耶鲁大学系统生物学融合研究生培训

• 批准号: 10641745
• 负责人: KATHRYN MILLER-JENSEN
• 金额: $ 21.22万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641745
• 关键词: Systems Biology; Training

The training program “Convergent Training in Systems Biology at Yale” will train students to tackle contemporary problems in biomedical research using a systems biology approach, which integrates experimental techniques with computational and mathematical modeling. Trainees will investigate biological systems as dynamic, multi- scale biological networks that span a wide range of time and length scales from genes to cells and tissues. By combining innovative coursework with mandatory professional development activities to improve their communication, leadership, and career self-efficacy, trainees will enter the biomedical workforce and make significant contributions to systems biology. We seek funding for 5 student slots per year to fund two consecutive years of the first three years of study per trainee, with Yale funding the remaining year. Trainees will enter the training program through 9 participating home departments/programs: Biomedical Engineering; Mechanical Engineering & Materials Science; Computational Biology & Bioinformatics; Cell Biology; Genetics; Molecular, Cellular, & Developmental Biology; Molecular Biophysics & Biochemistry; Physics; and Applied Physics. Trainees will develop disciplinary expertise through their home department/program, and systems biology knowledge through program coursework, featuring evidence-based teaching methods, such as peer-learning and team science to develop trainees’ ability to collaborate and communicate across disciplines. Additionally, several courses feature a modular format in which trainers with diverse, but complementary backgrounds, co- teach. To bring all students to a common level of knowledge, the training program offers primer courses in mathematics/computer programming and biology. Trainees will complete all training program and departmental course requirements in the first two years and will join their Ph.D. thesis lab in year one. Therefore, the training program does not increase the time to the Ph.D. degree. The training program offers professional development workshops, program-specific internship opportunities, and seminars, pitch competitions, and other activities aimed at building a cohesive cohort. The training program is closely associated with the Program in Physics, Engineering and Biology (PEB), Systems Biology Institute, and Quantitative Biology Institute at Yale, which provide a larger research community for the training program. Yale’s West Campus and PEB will combine resources to provide 3 additional matching slots, which will allow the training program to support a total of 8 students out of the cohort of 13-15 training grant eligible Ph.D. students per year. The training program has a vigorous recruitment plan, which includes new and existing college/university partners (e.g. Morehouse College, University of Puerto Rico, Mayagüez, and Southern Connecticut State University) and an NSF REU Site, which allows the training program leadership to identify promising URM undergraduates interested in systems biology. Additionally, the program has well-developed tracking and evaluation components to identify and remediate any problem areas and ensure that the training program objectives are being achieved.

培训计划“耶鲁大学系统生物学融合培训”将培训学生解决当代 生物医学研究中的问题，使用系统生物学的方法，它集成了实验技术 通过计算和数学建模。学员将研究生物系统作为动态的，多- 规模生物网络，跨越从基因到细胞和组织的广泛的时间和长度尺度。通过 将创新课程与强制性专业发展活动相结合，以提高他们的 沟通，领导力和职业自我效能，学员将进入生物医学劳动力，使 对系统生物学的重大贡献。我们寻求资助5个学生插槽，每年资助两个连续的 每名学员前三年的学习时间是10年，耶鲁大学资助剩下的一年。学员将进入 通过9个参与家庭部门/计划的培训计划：生物医学工程;机械 工程与材料科学;计算生物学与生物信息学;细胞生物学;遗传学;分子， 细胞和发育生物学;分子生物物理学和生物化学;物理学;和应用物理学。 学员将通过他们的家庭部门/计划和系统生物学发展学科专业知识 通过课程学习获得知识，以基于证据的教学方法为特色，如同行学习 和团队科学，以培养学员跨学科合作和沟通的能力。此外，本发明还 一些课程采用模块形式，由具有不同但互补背景的培训员共同 教为了使所有学生达到一个共同的知识水平，培训计划提供初级课程， 数学/计算机编程和生物学。受训人员将完成所有培训计划和部门 课程要求，并将加入他们的博士学位。第一年的实验室因此，培训 这个项目并没有增加读博士的时间。℃下该培训计划提供专业发展 工作坊、特定计划的实习机会、研讨会、推介比赛和其他活动 旨在建立一个有凝聚力的群体。培训计划与物理学计划密切相关， 工程与生物学（PEB），系统生物学研究所和定量生物学研究所在耶鲁大学， 为培训计划提供更大的研究社区。耶鲁西校区和PEB将联合收割机 资源，以提供3个额外的匹配插槽，这将使培训计划，以支持共8 13-15岁的学生中有资格获得培训补助金的博士学位。学生每年。培训计划有一个 积极的招聘计划，其中包括新的和现有的学院/大学合作伙伴（如莫尔豪斯学院， 波多黎各大学、马亚圭斯和南康涅狄格州州立大学）和NSF REU站点， 允许培训计划的领导，以确定有前途的URM本科生感兴趣的系统生物学。 此外，该计划具有完善的跟踪和评估组件，可识别和补救任何 问题领域，并确保实现培训计划的目标。

项目成果

"Student-led workshop strengthens perceived discussion skills and community in an interdisciplinary graduate program".

• DOI: 10.1096/fba.2021-00165
• 发表时间: 2023-01
• 期刊: FASEB bioAdvances
• 影响因子: 2.7