IMSD at Rush University

拉什大学 IMSD

• 批准号: 10337199
• 负责人: Lena Al-Harthi
• 金额: $ 32.65万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10337199
• 关键词: Universities

Project summary/abstract: National data on career choices of emerging scientists indicate that less than 25% pursue a traditional independent pathway in an academic environment. This grim reality is even worse for underrepresented minorities (URM), who represent 39% of college age individuals yet only 13% of PhDs in life sciences. In 2015, we were awarded a NIGM R25 Initiative for Maximizing Student Development (Rush-IMSD). Rush R25-IMSD was charged with training pre-doctoral URMs in biological sciences at Rush University in Chicago, IL. Although Rush R25-IMSD was a budding program, we achieved an impressive track record in our first 5 years of training and retaining of PhD URMs students, some of whom received F31s and/or research supplement awards. This formal structure dedicated to URM PhD training, a first at Rush, was instrumental in building alliances to promote URM education within and outside of our university. Specifically, Rush R25-IMSD is a documented success aligned with institutional commitment for diversity and inclusion. With the recognition that minorities continue to be underrepresented in PhD life science programs, and consequently the biomedical workforce does not reflect the diversity of our nation, we propose a new program for training of URM PhD students at Rush University under a T32 mechanism (as NIGM is phasing out R25 IMSDs). The pillars of T32 IMSD-Rush is a triad of rigorous mentoring, education, and research training of pre- doctoral URM students through harnessing the expertise of nationally recognized mentors and program faculty across several departments. Three students per year will be selected to participate in T32 IMSD-Rush and supported for the first three years of matriculation (an additional participant will be under institutional support). Together, we expect a cohort of 20 students over five years. The overarching goal of T32 IMSD-Rush will be attained through two interrelated specific aims: 1) Train emerging URM scientists in technical and operational basis of discipline-based research: T32 IMSD-Rush will be inter-and multidisciplinary program for training of URM PhD students in one of several disciplines (immunology/microbiology, physiology and biophysics, cell and molecular medicine, neurologic sciences, orthopedics/bioengineering). Participants will select a discipline and be matched with a primary mentor who along with nationally recognized leaders will guide the research development of the participant from idea conception to successful execution (e.g., the operational phase of training include knowledge acquisition, rigorous experimental design and data interpretation). Participants will also be trained in highly innovative and cutting-edge technology that can be used across disciplines to address impactful scientific questions and discoveries through designated workshops in imaging (live cell imaging, CT scans, confocal microscopy), small animal models (animal care, humanized mice, transgenic rats), molecular approaches (RNA/DNA scope, quantitative gene knockdown), quantitative and computational approaches (high-input statistics, bioinformatics) and training in scientific reproducibility and rigor. The participants will be captured early and integrated into the program through pre-matriculation (summer) training modules. Milestones include submission and acquisition of NIH individual predoctoral awards (F31) or individual predoctoral to postdoctoral fellow transition award (F99/K00), publication of two peer-reviewed manuscripts, one of which as a first author, and successful completion of the PhD program. 2) Implement and optimize best practices for training of emerging URM science investigators: Classical mentorship relies heavily on scientific research prowess. There is a greater recognition and appreciation that mentorship should be a holistic strategy, combining training in rigor in research with professional skills and network/alliance building to facilitate the development of a well-rounded emerging scientist, one who will successfully face the challenges of academic research, in particular, and of science in general. T32 IMSD-Rush will provide URM mentorship through direct and regular one-on-one contact and organized activities through workshops to maximize each participant’s professional development. These programs will include training modules on poster and oral presentations, emotional intelligence, conflict resolution, verbal and non-verbal communication, negotiations, financial budgeting/fiscal responsibility of running a team and/or lab, interviewing skills and most importantly building a culture of inclusion as a supportive network for URMs. Best practices will be used to train the participants. Mentors/program faculty will undergo mentorship training established by the National Research Mentoring Network (NRMN). Collectively, these initiatives are the cornerstones to ensure that T32 IMSD-Rush participants will be fully prepared to navigate the demands and challenges facing URM scientists. T32 IMSD-Rush will be evaluated through a well-integrated process to track, report, and assess long- term outcomes of trainees. Our findings will be shared through open dissemination of information and networking with organizations with similar interest. Our long-term goal is to increase enrollment of PhD URM students in biomedical sciences at Rush by at least 50%, with 90% successfully completing the program, and ≥50% will choose post-graduate training. Also, we envision that T32 IMSD-Rush instituted model for graduate student training will evolve into a platform that has university and community sustainability and sustained partnerships.

项目摘要/摘要：关于新兴科学家职业选择的国家数据表明，不到 25% 在学术环境中追求传统的独立途径。这个严峻的现实对于 代表性不足的少数群体 (URM)，占大学年龄人口的 39%，但仅占在职博士生的 13% 科学。 2015 年，我们获得了 NIGM R25 最大化学生发展计划 (Rush-IMSD)。 Rush R25-IMSD 负责在拉什大学培训生物科学博士前 URM 伊利诺伊州芝加哥。尽管 Rush R25-IMSD 是一个刚刚起步的项目，但我们在我们的项目中取得了令人印象深刻的记录 前 5 年培训和保留 URM 博士生，其中一些人获得了 F31 和/或研究 补充奖励。这种专门用于 URM 博士培训的正式结构是 Rush 的首创，在以下方面发挥了重要作用： 建立联盟以促进大学内外的 URM 教育。具体来说，Rush R25-IMSD 是有据可查的成功，与机构对多样性和包容性的承诺相一致。 认识到少数族裔在生命科学博士项目中的代表性仍然不足，并且 因此，生物医学劳动力并不能反映我们国家的多样性，我们提出了一个新计划 用于在 T32 机制下培训拉什大学的 URM 博士生（因为 NIGM 正在逐步淘汰 R25） IMSD）。 T32 IMSD-Rush 的支柱是严格的指导、教育和预科研究培训。 URM 博士生通过利用国家认可的导师和项目教师的专业知识 跨多个部门。每年将选出三名学生参加 T32 IMSD-Rush 和 为入学前三年提供支持（额外的参与者将获得机构支持）。 我们预计五年内将有 20 名学生组成。 T32 IMSD-Rush 的总体目标是 通过两个相互关联的具体目标来实现： 1) 在基于学科的研究的技术和操作基础上培训新兴的 URM 科学家： T32 IMSD-Rush 将是一个跨学科项目，用于培训 URM 博士生，其中几个项目之一 学科（免疫学/微生物学、生理学和生物物理学、细胞和分子医学、神经病学 科学、骨科/生物工程）。参与者将选择一个学科并与一位主要导师相匹配 他们与国家认可的领导者将从理念上指导参与者的研究发展 从构思到成功执行（例如，培训的操作阶段包括知识获取、 严格的实验设计和数据解释）。参与者还将接受高度创新和 可以跨学科使用的尖端技术来解决有影响力的科学问题 通过指定的成像研讨会（活细胞成像、CT 扫描、共聚焦显微镜）、小型 动物模型（动物护理、人源化小鼠、转基因大鼠）、分子方法（RNA/DNA 范围、 定量基因敲低）、定量和计算方法（高输入统计、生物信息学） 以及科学再现性和严谨性方面的培训。参与者将被尽早捕获并融入到 通过预科（夏季）培训模块进行计划。里程碑包括提交和获取 NIH 个人博士前奖（F31）或个人博士前到博士后研究员过渡奖 (F99/K00)，发表两篇同行评审的手稿，其中一篇作为第一作者，并成功 完成博士学位课程。 2) 实施和优化新兴 URM 科学研究人员培训的最佳实践： 古典导师很大程度上依赖于科学研究实力。有了更大的认可和认可 认识到指导应该是一项整体战略，将严格的研究培训与 专业技能和网络/联盟建设，以促进全面发展的新兴 科学家，一位能够成功应对学术研究挑战的人，特别是科学领域的挑战 一般的。 T32 IMSD-Rush 将通过直接和定期的一对一联系提供 URM 指导 通过研讨会组织活动，以最大限度地提高每个参与者的专业发展。这些 方案将包括关于海报和口头演示、情商、冲突的培训模块 决议、口头和非口头沟通、谈判、财务预算/运行的财政责任 团队和/或实验室、面试技巧，最重要的是建立包容文化作为支持网络 对于 URM。将使用最佳实践来培训参与者。导师/项目教师将接受指导 由国家研究指导网络（NRMN）建立的培训。 总的来说，这些举措是确保 T32 IMSD-Rush 参与者充分参与的基石。 准备应对 URM 科学家面临的需求和挑战。 T32 IMSD-Rush 将通过一个完善的集成流程进行评估，以跟踪、报告和评估长期 受训者的学期成果。我们的研究结果将通过公开传播信息和网络来分享 与具有相似兴趣的组织合作。我们的长期目标是增加 URM 博士生的入学率 Rush 生物医学科学专业至少 50%，其中 90% 成功完成该项目，并且 ≥50% 将 选择研究生培训。此外，我们还设想 T32 IMSD-Rush 为研究生建立模型 培训将发展成为一个具有大学和社区可持续性以及持续伙伴关系的平台。